Basic Information:

  VIRBase ID:  

VHID00325174

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART8-3p:  MIMAT0003418          EHF:  NR_165391     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART8-3p	EHF
miRBase Accession/Entrez ID	MIMAT0003418	26298
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ESE3//ESE3B//ESEJ

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EHF	chr11:34680232-34680233(+) m6A CDS       24981863 chr11:34680423-34680424(+) m6A CDS       24981863 chr11:34680473-34680474(+) m6A CDS       24981863//22575960 chr11:34680495-34680496(+) m6A 3'UTR       24981863//22575960 chr11:34680501-34680502(+) m6A 3'UTR       24981863//22575960 chr11:34680507-34680508(+) m6A 3'UTR       24981863//22575960 chr11:34680528-34680529(+) m6A 3'UTR       24981863//22575960 chr11:34680535-34680536(+) m6A 3'UTR       24981863//22575960 chr11:34680560-34680561(+) m6A 3'UTR       24981863//22575960 chr11:34680596-34680597(+) m6A 3'UTR       24981863 chr11:34680603-34680604(+) m6A 3'UTR       24981863 chr11:34680626-34680627(+) m6A 3'UTR       24981863 chr11:34680964-34680965(+) m6A 3'UTR       24981863 chr11:34681028-34681029(+) m6A 3'UTR       24981863 chr11:34681037-34681038(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EHF	Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART8-3p
Interactor2: EHF

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.