Detail Information

Basic Information:


  VIRBase ID:  

VHID00324885

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART8-3p:           BTN2A1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART8-3p BTN2A1
miRBase
Accession/Entrez ID		 MIMAT0003418 11120
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - BK14H9.1//BT2.1//BTF1//BTN2.1//DJ3E1.1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BTN2A1
chr6:26475954(+) A-I      intronic
chr6:26461125(+) A-I      intronic
chr6:26475106(+) A-I      intronic
chr6:26475041(+) A-I      intronic
chr6:26475928(+) A-I      intronic
chr6:26475927(+) A-I      intronic
chr6:26475910(+) A-I      intronic
chr6:26475897(+) A-I      intronic
chr6:26475880(+) A-I      intronic
chr6:26475226(+) A-I      intronic
chr6:26475161(+) A-I      intronic
chr6:26475267(+) A-I      intronic
chr6:26475094(+) A-I      intronic
chr6:26462779(+) A-I      intronic
chr6:26475230(+) A-I      intronic
chr6:26475060(+) A-I      intronic
chr6:26475042(+) A-I      intronic
chr6:26470452(+) A-I      intronic
chr6:26470454(+) A-I      intronic
chr6:26475225(+) A-I      intronic
chr6:26460398(+) A-I      intronic
chr6:26465775(+) A-I      intronic
chr6:26475252(+) A-I      intronic
chr6:26467579(+) A-I      intronic
chr6:26470428(+) A-I      intronic
chr6:26470524(+) A-I      intronic
chr6:26464298(+) A-I      intronic
chr6:26464078(+) A-I      intronic
chr6:26470253(+) A-I      intronic
chr6:26460881(+) A-I      intronic
chr6:26475253(+) A-I      intronic
chr6:26470334(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BTN2A1
chr6:26468152(+) C-A intron -    21725310
chr6:26461063(+) A-G intron -    22484847
chr6:26467579(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BTN2A1
chr6:26458152-26458153(+) m6A 5'UTR       24981863
chr6:26458161-26458162(+) m6A 5'UTR       24981863
chr6:26458179-26458180(+) m6A 5'UTR       24981863
chr6:26458206-26458207(+) m6A 5'UTR       24981863
chr6:26458233-26458234(+) m6A 5'UTR       24981863
chr6:26458330-26458331(+) m6A 5'UTR       24284625//24981863
chr6:26459762-26459763(+) m6A 5'UTR//CDS       -
chr6:26459807-26459808(+) m6A 5'UTR//CDS       -
chr6:26459878-26459879(+) m6A CDS       -
chr6:26459911-26459912(+) m6A CDS       -
chr6:26459930-26459931(+) m6A CDS       -
chr6:26465512-26465513(+) m6A 3'UTR//CDS       24981863//27773535
chr6:26465564-26465565(+) m6A 3'UTR//CDS       24981863//27773535
chr6:26465587-26465588(+) m6A 3'UTR//CDS       24981863//27773535
chr6:26465620-26465621(+) m6A 3'UTR//CDS       24981863//27773535
chr6:26466184-26466185(+) m6A 3'UTR//CDS       24981863
chr6:26466300-26466301(+) m6A 3'UTR//CDS       24981863
chr6:26468162-26468163(+) m6A 3'UTR//intron       24981863
chr6:26468196-26468197(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085
chr6:26468229-26468230(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085
chr6:26468347-26468348(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:26468387-26468388(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:26468406-26468407(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:26468459-26468460(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:26468556-26468557(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr6:26468595-26468596(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085
chr6:26468673-26468674(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085
chr6:26468759-26468760(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085
chr6:26468807-26468808(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr6:26468856-26468857(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr6:26468889-26468890(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr6:26468924-26468925(+) m6A 3'UTR//intron       24284625//24209618//24981863//22608085
chr6:26469013-26469014(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26469071-26469072(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr6:26469137-26469138(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26469195-26469196(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26469215-26469216(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26469249-26469250(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26469267-26469268(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26469313-26469314(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26469380-26469381(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr6:26469404-26469405(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr6:26469521-26469522(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26469555-26469556(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr6:26469571-26469572(+) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//22608085
chr6:26469682-26469683(+) m6A 3'UTR//intron       27773535//22608085
chr6:26476443-26476444(+) m6A 3'UTR       -
chr6:26476493-26476494(+) m6A 3'UTR       -
chr6:26476565-26476566(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BTN2A1
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART8-3p
Interactor2: BTN2A1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

Starting a new search, please wait ...