Detail Information

Basic Information:


  VIRBase ID:  

VHID00321808

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:           PDZD8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART7-3p PDZD8
miRBase
Accession/Entrez ID		 MIMAT0003416 118987
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - PDZK8

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PDZD8
chr10:119133012(-) A-I      intronic
chr10:119133003(-) A-I      intronic
chr10:119133018(-) A-I      intronic
chr10:119131253(-) A-I      intronic
chr10:119133025(-) A-I      intronic
chr10:119092274(-) A-I      intronic
chr10:119092290(-) A-I      intronic
chr10:119092426(-) A-I      intronic
chr10:119092462(-) A-I      intronic
chr10:119092473(-) A-I      intronic
chr10:119092115(-) A-I      intronic
chr10:119092482(-) A-I      intronic
chr10:119092490(-) A-I      intronic
chr10:119092506(-) A-I      intronic
chr10:119050852(-) A-I      intronic
chr10:119092513(-) A-I      intronic
chr10:119110339(-) A-I      intronic
chr10:119109881(-) A-I      intronic
chr10:119110021(-) A-I      intronic
chr10:119126806(-) A-I      intronic
chr10:119127188(-) A-I      intronic
chr10:119127201(-) A-I      intronic
chr10:119127345(-) A-I      intronic
chr10:119128434(-) A-I      intronic
chr10:119060602(-) A-I      intronic
chr10:119104140(-) A-I      intronic
chr10:119127355(-) A-I      intronic
chr10:119088046(-) A-I      intronic
chr10:119110300(-) A-I      intronic
chr10:119109913(-) A-I      intronic
chr10:119089341(-) A-I      intronic
chr10:119128921(-) A-I      intronic
chr10:119092495(-) A-I      intronic
chr10:119110303(-) A-I      intronic
chr10:119133179(-) A-I      intronic
chr10:119128463(-) A-I      intronic
chr10:119131397(-) A-I      intronic
chr10:119131385(-) A-I      intronic
chr10:119131258(-) A-I      intronic
chr10:119131228(-) A-I      intronic
chr10:119130952(-) A-I      intronic
chr10:119130946(-) A-I      intronic
chr10:119130929(-) A-I      intronic
chr10:119130828(-) A-I      intronic
chr10:119130180(-) A-I      intronic
chr10:119109980(-) A-I      intronic
chr10:119092583(-) A-I      intronic
chr10:119092425(-) A-I      intronic
chr10:119051164(-) A-I      intronic
chr10:119130123(-) A-I      intronic
chr10:119064739(-) A-I      intronic
chr10:119064744(-) A-I      intronic
chr10:119128802(-) A-I      intronic
chr10:119064761(-) A-I      intronic
chr10:119083559(-) A-I      intronic
chr10:119088128(-) A-I      intronic
chr10:119083573(-) A-I      intronic
chr10:119083607(-) A-I      intronic
chr10:119089265(-) A-I      intronic
chr10:119089317(-) A-I      intronic
chr10:119092047(-) A-I      intronic
chr10:119128755(-) A-I      intronic
chr10:119128459(-) A-I      intronic
chr10:119110070(-) A-I      intronic
chr10:119092110(-) A-I      intronic
chr10:119092114(-) A-I      intronic
chr10:119092146(-) A-I      intronic
chr10:119092520(-) A-I      intronic
chr10:119126873(-) A-I      intronic
chr10:119048222(-) A-I      intronic
chr10:119050554(-) A-I      intronic
chr10:119131216(-) A-I      intronic
chr10:119109971(-) A-I      intronic
chr10:119111350(-) A-I      intronic
chr10:119133089(-) A-I      intronic
chr10:119130109(-) A-I      intronic
chr10:119133287(-) A-I      intronic
chr10:119126742(-) A-I      intronic
chr10:119060717(-) A-I      intronic
chr10:119092547(-) A-I      intronic
chr10:119050535(-) A-I      intronic
chr10:119126813(-) A-I      intronic
chr10:119109976(-) A-I      intronic
chr10:119092548(-) A-I      intronic
chr10:119109970(-) A-I      intronic
chr10:119109879(-) A-I      intronic
chr10:119050577(-) A-I      intronic
chr10:119130834(-) A-I      intronic
chr10:119051111(-) A-I      intronic
chr10:119131449(-) A-I      intronic
chr10:119060669(-) A-I      intronic
chr10:119092083(-) A-I      intronic
chr10:119051137(-) A-I      intronic
chr10:119092411(-) A-I      intronic
chr10:119130991(-) A-I      intronic
chr10:119110047(-) A-I      intronic
chr10:119092182(-) A-I      intronic
chr10:119074984(-) A-I      intronic
chr10:119088132(-) A-I      intronic
chr10:119110368(-) A-I      intronic
chr10:119133169(-) A-I      intronic
chr10:119131418(-) A-I      intronic
chr10:119131338(-) A-I      intronic
chr10:119088111(-) A-I      intronic
chr10:119092553(-) A-I      intronic
chr10:119085187(-) A-I      intronic
chr10:119131410(-) A-I      intronic
chr10:119109928(-) A-I      intronic
chr10:119109904(-) A-I      intronic
chr10:119092128(-) A-I      intronic
chr10:119106774(-) A-I      intronic
chr10:119126759(-) A-I      intronic
chr10:119092554(-) A-I      intronic
chr10:119106767(-) A-I      intronic
chr10:119040690(-) A-I      3'UTR
chr10:119092518(-) A-I      intronic
chr10:119092166(-) A-I      intronic
chr10:119110328(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PDZD8
chr10:119106767(-) A-G intron -    22484847
chr10:119106774(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PDZD8
chr10:119040005-119040006(-) m6A 3'UTR       27773535
chr10:119040018-119040019(-) m6A 3'UTR       27773535
chr10:119040143-119040144(-) m6A 3'UTR       27773535
chr10:119040941-119040942(-) m6A 3'UTR       27773535
chr10:119041799-119041800(-) m6A 3'UTR       27773535
chr10:119041875-119041876(-) m6A 3'UTR       27773535
chr10:119042619-119042620(-) m6A 3'UTR       24981863//27773535//22575960//22608085
chr10:119042651-119042652(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr10:119042748-119042749(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119042774-119042775(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119042836-119042837(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119042866-119042867(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119042914-119042915(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119042936-119042937(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119043053-119043054(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr10:119043087-119043088(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr10:119043138-119043139(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr10:119043259-119043260(-) m6A CDS       24209618//24981863//26404942//27773535//27371828//22608085
chr10:119043280-119043281(-) m6A CDS       24209618//24981863//26404942//27773535//27371828//22608085
chr10:119043316-119043317(-) m6A CDS       24209618//24981863//26404942//27773535//27371828//22608085
chr10:119043336-119043337(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr10:119043348-119043349(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119043362-119043363(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119043369-119043370(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119043383-119043384(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119043452-119043453(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119043509-119043510(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119043516-119043517(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119043532-119043533(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119043542-119043543(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119043547-119043548(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119043581-119043582(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119043656-119043657(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119043694-119043695(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119043727-119043728(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119043747-119043748(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119043801-119043802(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr10:119043838-119043839(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr10:119043938-119043939(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119043975-119043976(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119044000-119044001(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119044038-119044039(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119044108-119044109(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119044157-119044158(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119044163-119044164(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119044211-119044212(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119044231-119044232(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119044250-119044251(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:119044410-119044411(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119044479-119044480(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119044503-119044504(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119044522-119044523(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119044538-119044539(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119044554-119044555(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119044618-119044619(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr10:119044647-119044648(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr10:119044744-119044745(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr10:119044840-119044841(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27371828//22575960//22608085
chr10:119133995-119133996(-) m6A CDS       27773535
chr10:119134112-119134113(-) m6A CDS       27371828//27773536
chr10:119134263-119134264(-) m6A CDS       27371828//27773536//22608085
chr10:119134341-119134342(-) m6A CDS       27371828//27773536//22608085
chr10:119134406-119134407(-) m6A CDS       27371828//27773536//22608085
chr10:119134458-119134459(-) m6A CDS       27371828//27773536
chr10:119134482-119134483(-) m6A CDS       27371828//27773536
chr10:119134651-119134652(-) m6A CDS       27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BART7-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
PDZD8
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART7-3p
Interactor2: PDZD8

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase//VIRmiRNA

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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