Basic Information:

  VIRBase ID:  

VHID00321571

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:  MIMAT0003416          TXNDC5:  NM_022085     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART7-3p	TXNDC5
miRBase Accession/Entrez ID	MIMAT0003416	81567
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ENDOPDI//ERP46//HCC-2//HCC2//PDIA15//STRF8//UNQ364

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TXNDC5	chr6:7882611-7882612(-) m6A 3'UTR//exon       24981863//26404942 chr6:7882658-7882659(-) m6A 3'UTR//exon       24981863//26404942 chr6:7882867-7882868(-) m6A 3'UTR//exon       26404942//22575960 chr6:7883049-7883050(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085 chr6:7883083-7883084(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085 chr6:7883149-7883150(-) m6A 3'UTR//exon       24284625//24981863 chr6:7883267-7883268(-) m6A 3'UTR//exon       24284625 chr6:7883373-7883374(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960 chr6:7883382-7883383(-) m6A CDS//exon       24284625//24981863//26404942//22575960 chr6:7883428-7883429(-) m6A CDS//exon       24284625//24981863//26404942//22575960 chr6:7884628-7884629(-) m6A CDS//exon       24284625//22575960 chr6:7884681-7884682(-) m6A CDS//exon       22575960 chr6:7884704-7884705(-) m6A CDS//exon       22575960 chr6:7888990-7888991(-) m6A CDS//exon       24981863//26404942//27773536//22575960 chr6:7889005-7889006(-) m6A CDS//exon       24981863//26404942//27773536//22575960 chr6:7889113-7889114(-) m6A exon//intron       24981863//26404942//27773536//22575960 chr6:7889125-7889126(-) m6A exon//intron       24981863//26404942//27773536//22575960 chr6:7889184-7889185(-) m6A exon//intron       27773536 chr6:7889437-7889438(-) m6A exon//intron       24284625 chr6:7889453-7889454(-) m6A exon//intron       24284625 chr6:7889459-7889460(-) m6A exon//intron       24284625 chr6:7889776-7889777(-) m6A CDS       27773536//22575960//22608085 chr6:7889790-7889791(-) m6A CDS       27773536//22575960 chr6:7891870-7891871(-) m6A CDS       22575960 chr6:7891880-7891881(-) m6A CDS       22575960 chr6:7895414-7895415(-) m6A CDS//exon       27773535//22575960 chr6:7898846-7898847(-) Gm intron       - chr6:7899828-7899829(-) m6A CDS//exon       27773535//22575960 chr6:7899842-7899843(-) m6A CDS//exon       27773535//22575960 chr6:7899852-7899853(-) m6A CDS//exon       27773535//22575960 chr6:7899860-7899861(-) m6A CDS//exon       27773535//22575960 chr6:7899957-7899958(-) m6A exon//intron       27773535 chr6:7904860-7904861(-) m6A CDS       26404942//27773535//22575960 chr6:7904898-7904899(-) Cm 5'UTR//CDS       - chr6:7904908-7904909(-) m6A 5'UTR//CDS       26404942//27773535//22575960 chr6:7904949-7904950(-) m6A 5'UTR//CDS       24284625//24209618//27773535//22575960 chr6:7910054-7910055(-) m6A 5'UTR//intron       24284625//24209618//22575960 chr6:7910102-7910103(-) m6A 5'UTR//intron       24284625//24209618//27773536 chr6:7910197-7910198(-) m6A 5'UTR//intron       24209618//27773536 chr6:7910833-7910834(-) m6A CDS       24284625//24209618//27371828//27773536//22575960 chr6:7910838-7910839(-) m6A CDS       24284625//24209618//27371828//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	TXNDC5	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART7-3p
Interactor2: TXNDC5

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase//VIRmiRNA

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	Downregulation
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).