Detail Information

Basic Information:


  VIRBase ID:  

VHID00321561

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:           SETD7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART7-3p SETD7
miRBase
Accession/Entrez ID		 MIMAT0003416 80854
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - KMT7//SET7//SET7/9//SET9

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SETD7
chr4:140447337(-) A-I      intronic
chr4:140447320(-) A-I      intronic
chr4:140442458(-) A-I      intronic
chr4:140438449(-) A-I      intronic
chr4:140438446(-) A-I      intronic
chr4:140438441(-) A-I      intronic
chr4:140438431(-) A-I      intronic
chr4:140434567(-) A-I      intronic
chr4:140434491(-) A-I      intronic
chr4:140434466(-) A-I      intronic
chr4:140434452(-) A-I      intronic
chr4:140434411(-) A-I      intronic
chr4:140434408(-) A-I      intronic
chr4:140434394(-) A-I      intronic
chr4:140434389(-) A-I      intronic
chr4:140434114(-) A-I      intronic
chr4:140453350(-) A-I      intronic
chr4:140436281(-) A-I      intronic
chr4:140471325(-) A-I      intronic
chr4:140434107(-) A-I      intronic
chr4:140434063(-) A-I      intronic
chr4:140433980(-) A-I      intronic
chr4:140433942(-) A-I      intronic
chr4:140418446(-) A-I      intronic
chr4:140471097(-) A-I      intronic
chr4:140471080(-) A-I      intronic
chr4:140469674(-) A-I      intronic
chr4:140459691(-) A-I      intronic
chr4:140459687(-) A-I      intronic
chr4:140459686(-) A-I      intronic
chr4:140458332(-) A-I      intronic
chr4:140458327(-) A-I      intronic
chr4:140436268(-) A-I      intronic
chr4:140436263(-) A-I      intronic
chr4:140436257(-) A-I      intronic
chr4:140434020(-) A-I      intronic
chr4:140434018(-) A-I      intronic
chr4:140458326(-) A-I      intronic
chr4:140458035(-) A-I      intronic
chr4:140458009(-) A-I      intronic
chr4:140458008(-) A-I      intronic
chr4:140457985(-) A-I      intronic
chr4:140457965(-) A-I      intronic
chr4:140457703(-) A-I      intronic
chr4:140457700(-) A-I      intronic
chr4:140457640(-) A-I      intronic
chr4:140457622(-) A-I      intronic
chr4:140457621(-) A-I      intronic
chr4:140455800(-) A-I      intronic
chr4:140455726(-) A-I      intronic
chr4:140455707(-) A-I      intronic
chr4:140447689(-) A-I      intronic
chr4:140447688(-) A-I      intronic
chr4:140447675(-) A-I      intronic
chr4:140447656(-) A-I      intronic
chr4:140434522(-) A-I      intronic
chr4:140420210(-) A-I      intronic
chr4:140470861(-) A-I      intronic
chr4:140434560(-) A-I      intronic
chr4:140447646(-) A-I      intronic
chr4:140434172(-) A-I      intronic
chr4:140458448(-) A-I      intronic
chr4:140447556(-) A-I      intronic
chr4:140448626(-) A-I      intronic
chr4:140434465(-) A-I      intronic
chr4:140458402(-) A-I      intronic
chr4:140444086(-) A-I      intronic
chr4:140448596(-) A-I      intronic
chr4:140447562(-) A-I      intronic
chr4:140433984(-) A-I      intronic
chr4:140447634(-) A-I      intronic
chr4:140433979(-) A-I      intronic
chr4:140434050(-) A-I      intronic
chr4:140434391(-) A-I      intronic
chr4:140448706(-) A-I      intronic
chr4:140426660(-) A-I      intronic
chr4:140433994(-) A-I      intronic
chr4:140426721(-) A-I      intronic
chr4:140447516(-) A-I      intronic
chr4:140447526(-) A-I      intronic
chr4:140435393(-) A-I      intronic
chr4:140444158(-) A-I      intronic
chr4:140434049(-) A-I      intronic
chr4:140438432(-) A-I      intronic
chr4:140434112(-) A-I      intronic
chr4:140458466(-) A-I      intronic
chr4:140448679(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SETD7
chr4:140417430-140417431(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr4:140417449-140417450(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr4:140417480-140417481(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr4:140417539-140417540(-) m6A CDS//exon       24981863//22608085
chr4:140417581-140417582(-) m6A CDS//exon       22608085
chr4:140428065-140428066(-) m6A 3'UTR//intron       27773535
chr4:140428085-140428086(-) m6A 3'UTR//intron       27773535
chr4:140428209-140428210(-) m6A 3'UTR//intron       27773535
chr4:140428222-140428223(-) m6A 3'UTR//intron       27773535
chr4:140428310-140428311(-) m6A 3'UTR//intron       27773535
chr4:140428318-140428319(-) m6A 3'UTR//intron       27773535
chr4:140428332-140428333(-) m6A 3'UTR//intron       27773535
chr4:140428391-140428392(-) m6A 3'UTR//intron       27773535
chr4:140429469-140429470(-) m6A 3'UTR//intron       24284625//22608085
chr4:140429489-140429490(-) Y 3'UTR//intron       26075521
chr4:140429582-140429583(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:140429594-140429595(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:140429604-140429605(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:140429616-140429617(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:140429646-140429647(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr4:140432502-140432503(-) m6A 3'UTR//intron       27773535
chr4:140432508-140432509(-) m6A 3'UTR//intron       27773535
chr4:140432575-140432576(-) m6A 3'UTR//intron       24284625//24209618//26404942//27773535//22608085
chr4:140432644-140432645(-) Y 3'UTR//intron       26075521
chr4:140432732-140432733(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr4:140432742-140432743(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr4:140432778-140432779(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr4:140432791-140432792(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr4:140439053-140439054(-) m6A CDS//exon       27773535
chr4:140450289-140450290(-) m6A CDS       24981863//27773535
chr4:140454217-140454218(-) m6A 3'UTR//intron       27773535
chr4:140454233-140454234(-) m6A 3'UTR//intron       27773535
chr4:140454319-140454320(-) Cm 3'UTR//CDS       -
chr4:140454381-140454382(-) m6A 3'UTR//CDS       24209618//27773535//22575960
chr4:140468127-140468128(-) m6A CDS       24284625//24209618//27773535//27371828//22575960
chr4:140468142-140468143(-) m6A CDS       24284625//24209618//27773535//27371828
chr4:140469182-140469183(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//27371828//27773536
chr4:140477385-140477386(-) m6A 5'UTR//intron       24284625//24209618//24981863//27371828//27773536
chr4:140477661-140477662(-) m6A 5'UTR//intron       24284625//24981863//27371828//22608085
chr4:140477668-140477669(-) m6A 5'UTR//intron       24284625//24981863//27371828//22608085
chr4:140477811-140477812(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536//22608085
chr4:140477903-140477904(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536
chr4:140477917-140477918(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536
chr4:140477923-140477924(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536
chr4:140517802-140517803(-) m6A 3'UTR//intron       24284625//24981863//27773536
chr4:140517867-140517868(-) m6A 3'UTR//intron       24981863//27773536
chr4:140517880-140517881(-) m6A 3'UTR//intron       24981863//27773536
chr4:140517949-140517950(-) m6A 3'UTR//intron       24981863
chr4:140517957-140517958(-) m6A 3'UTR//intron       24981863
chr4:140518567-140518568(-) m6A 3'UTR//intron       24981863//27773536
chr4:140518604-140518605(-) m6A 3'UTR//intron       24284625//24981863//27773536
chr4:140518639-140518640(-) m6A 3'UTR//intron       24284625//24981863//27773535//27773536
chr4:140518652-140518653(-) m6A 3'UTR//intron       24284625//24981863//27773535//27773536
chr4:140518684-140518685(-) m6A 3'UTR//intron       24284625//24981863//27773535//27773536
chr4:140518693-140518694(-) m6A 3'UTR//intron       24284625//24981863//27773535//27773536
chr4:140518706-140518707(-) m6A 3'UTR//intron       24284625//24981863//27773535//27773536
chr4:140518737-140518738(-) m6A 3'UTR//intron       24284625//24981863//27773536
chr4:140518756-140518757(-) m6A 3'UTR//intron       24284625//24981863//27773536
chr4:140518803-140518804(-) m6A 3'UTR//intron       24284625
chr4:140518950-140518951(-) m6A 3'UTR//intron       24981863
chr4:140520934-140520935(-) m6A 3'UTR//intron       27773535
chr4:140522028-140522029(-) m6A 3'UTR//intron       24981863
chr4:140522069-140522070(-) m6A 3'UTR//intron       24981863
chr4:140522111-140522112(-) m6A 3'UTR//intron       24981863
chr4:140522215-140522216(-) m6A 3'UTR//intron       24284625//24981863
chr4:140522239-140522240(-) m6A 3'UTR//intron       24284625//24981863
chr4:140522313-140522314(-) m6A 3'UTR//intron       24981863
chr4:140522327-140522328(-) m6A 3'UTR//intron       24981863
chr4:140522464-140522465(-) m6A 3'UTR//intron       24284625//24981863
chr4:140522579-140522580(-) m6A 3'UTR//intron       24284625//24981863
chr4:140522600-140522601(-) m6A CDS//intron       24284625//24981863
chr4:140522619-140522620(-) m6A CDS//intron       24284625//24981863
chr4:140522638-140522639(-) m6A CDS//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BART7-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
SETD7
Cytosol K562 cells     -
Exosome Blood     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART7-3p
Interactor2: SETD7

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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