Basic Information:

  VIRBase ID:  

VHID00321452

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:  MIMAT0003416          DERL1:  NM_001363963     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART7-3p	DERL1
miRBase Accession/Entrez ID	MIMAT0003416	79139
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DER-1//DER1//derlin-1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DERL1	chr8:124045920(-) A-I      intronic chr8:124045821(-) A-I      intronic chr8:124045754(-) A-I      intronic chr8:124045161(-) A-I      intronic chr8:124045835(-) A-I      intronic chr8:124045900(-) A-I      intronic chr8:124045376(-) A-I      intronic chr8:124045265(-) A-I      intronic chr8:124045240(-) A-I      intronic chr8:124045209(-) A-I      intronic chr8:124045767(-) A-I      intronic chr8:124045378(-) A-I      intronic chr8:124044467(-) A-I      intronic chr8:124044472(-) A-I      intronic chr8:124045871(-) A-I      intronic chr8:124045976(-) A-I      intronic chr8:124045164(-) A-I      intronic chr8:124043702(-) A-I      intronic chr8:124045223(-) A-I      intronic chr8:124045182(-) A-I      intronic chr8:124044542(-) A-I      intronic chr8:124042217(-) A-I      intronic chr8:124044477(-) A-I      intronic chr8:124045983(-) A-I      intronic chr8:124044554(-) A-I      intronic chr8:124044550(-) A-I      intronic chr8:124044607(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DERL1	chr8:124043702(-) A-G intron -    22484847 chr8:124044550(-) A-G intron -    22484847 chr8:124045164(-) A-G intron -    22484847 chr8:124045240(-) A-G intron -    22484847 chr8:124045265(-) A-G intron -    22484847 chr8:124045378(-) A-G intron -    22484847 chr8:124045739(-) A-G intron -    22484847 chr8:124045767(-) A-G intron -    22484847 chr8:124045861(-) A-G intron -    22484847 chr8:124045871(-) A-G intron -    22484847 chr8:124045921(-) A-G intron -    22484847 chr8:124045976(-) A-G intron -    22484847 chr8:124045983(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DERL1	chr8:124027128-124027129(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr8:124027150-124027151(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr8:124027330-124027331(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr8:124027345-124027346(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr8:124027448-124027449(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085 chr8:124027475-124027476(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085 chr8:124027558-124027559(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22608085 chr8:124027594-124027595(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr8:124027693-124027694(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr8:124027725-124027726(-) m6A CDS//exon       24284625//24209618//27773535//27371828//22608085 chr8:124054345-124054346(-) m6A CDS       27773536 chr8:124054354-124054355(-) m6A CDS       27773536 chr8:124054453-124054454(-) m6A 5'UTR       24981863//27371828//27773536 chr8:124054589-124054590(-) m6A 5'UTR       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	DERL1	Chromatin HeLa-S3 cells|K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART7-3p
Interactor2: DERL1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.