Basic Information:

  VIRBase ID:  

VHID00321283

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:  MIMAT0003416          RAB22A:  NM_020673     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART7-3p	RAB22A
miRBase Accession/Entrez ID	MIMAT0003416	57403
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RAB22A	chr20:56889209(+) A-I      intronic chr20:56913273(+) A-I      intronic chr20:56933717(+) A-I      intronic chr20:56933963(+) A-I      intronic chr20:56889124(+) A-I      intronic chr20:56887753(+) A-I      intronic chr20:56887822(+) A-I      intronic chr20:56889635(+) A-I      intronic chr20:56889735(+) A-I      intronic chr20:56904361(+) A-I      intronic chr20:56904316(+) A-I      intronic chr20:56899776(+) A-I      intronic chr20:56899721(+) A-I      intronic chr20:56899716(+) A-I      intronic chr20:56899714(+) A-I      intronic chr20:56889721(+) A-I      intronic chr20:56899713(+) A-I      intronic chr20:56899647(+) A-I      intronic chr20:56895880(+) A-I      intronic chr20:56895854(+) A-I      intronic chr20:56893159(+) A-I      intronic chr20:56892943(+) A-I      intronic chr20:56892937(+) A-I      intronic chr20:56892714(+) A-I      intronic chr20:56892327(+) A-I      intronic chr20:56889854(+) A-I      intronic chr20:56904371(+) A-I      intronic chr20:56892292(+) A-I      intronic chr20:56913183(+) A-I      intronic chr20:56889884(+) A-I      intronic chr20:56889816(+) A-I      intronic chr20:56887076(+) A-I      intronic chr20:56902113(+) A-I      intronic chr20:56896905(+) A-I      intronic chr20:56889817(+) A-I      intronic chr20:56889818(+) A-I      intronic chr20:56900112(+) A-I      intronic chr20:56913266(+) A-I      intronic chr20:56913257(+) A-I      intronic chr20:56940739(+) A-I      3'UTR chr20:56902108(+) A-I      intronic chr20:56896081(+) A-I      intronic chr20:56913222(+) A-I      intronic chr20:56896264(+) A-I      intronic chr20:56889161(+) A-I      intronic chr20:56896926(+) A-I      intronic chr20:56889304(+) A-I      intronic chr20:56893005(+) A-I      intronic chr20:56913334(+) A-I      intronic chr20:56913182(+) A-I      intronic chr20:56913187(+) A-I      intronic chr20:56902114(+) A-I      intronic chr20:56889736(+) A-I      intronic chr20:56896969(+) A-I      intronic chr20:56889737(+) A-I      intronic chr20:56903262(+) A-I      intronic chr20:56889166(+) A-I      intronic chr20:56889355(+) A-I      intronic chr20:56889310(+) A-I      intronic chr20:56913294(+) A-I      intronic chr20:56903372(+) A-I      intronic chr20:56889204(+) A-I      intronic chr20:56913157(+) A-I      intronic chr20:56896995(+) A-I      intronic chr20:56896936(+) A-I      intronic chr20:56913293(+) A-I      intronic chr20:56913263(+) A-I      intronic chr20:56889720(+) A-I      intronic chr20:56893012(+) A-I      intronic chr20:56896950(+) A-I      intronic chr20:56896125(+) A-I      intronic chr20:56889776(+) A-I      intronic chr20:56913152(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RAB22A	chr20:56913152(+) A-I intron -    15342557 chr20:56913157(+) A-I intron -    15342557 chr20:56913182(+) A-I intron -    15342557 chr20:56913183(+) A-I intron -    15342557 chr20:56913187(+) A-I intron -    15342557 chr20:56913212(+) A-I intron -    15342557 chr20:56913216(+) A-I intron -    15342557 chr20:56913222(+) A-I intron -    15342557 chr20:56913257(+) A-I intron -    15342557 chr20:56913263(+) A-I intron -    15342557 chr20:56913266(+) A-I intron -    15342557 chr20:56913293(+) A-I intron -    15342557 chr20:56913334(+) A-I intron -    15342557 chr20:56914558(+) A-I intron -    15342557 chr20:56916094(+) A-I intron -    15342557 chr20:56896950(+) A-G intron -    22484847 chr20:56926617(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAB22A	chr20:56884871-56884872(+) m6A 5'UTR//exon       24209618//24981863 chr20:56884880-56884881(+) m6A 5'UTR//exon       24209618//24981863 chr20:56884920-56884921(+) m6A 5'UTR//exon       24209618 chr20:56884994-56884995(+) Y 5'UTR//exon       26075521 chr20:56934716-56934717(+) m6A CDS       24284625//24209618//24981863//22608085 chr20:56934725-56934726(+) m6A CDS       24284625//24209618//24981863//22608085 chr20:56934763-56934764(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr20:56934778-56934779(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr20:56934894-56934895(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr20:56934914-56934915(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr20:56934942-56934943(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr20:56934979-56934980(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr20:56935014-56935015(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr20:56935128-56935129(+) m6A 3'UTR       24981863//22608085 chr20:56935228-56935229(+) m6A 3'UTR       27773535 chr20:56941639-56941640(+) m6A 3'UTR       24981863 chr20:56941681-56941682(+) m6A 3'UTR       24981863 chr20:56941699-56941700(+) m6A 3'UTR       24981863 chr20:56941715-56941716(+) m6A 3'UTR       24981863 chr20:56941741-56941742(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	RAB22A	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART7-3p
Interactor2: RAB22A

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.