Basic Information:

  VIRBase ID:  

VHID00321172

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:  MIMAT0003416          G2E3:  NM_017769     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART7-3p	G2E3
miRBase Accession/Entrez ID	MIMAT0003416	55632
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA1333//PHF7B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	G2E3	chr14:31050810(+) A-I      intronic chr14:31033030(+) A-I      intronic chr14:31067472(+) A-I      intronic chr14:31072814(+) A-I      intronic chr14:31071990(+) A-I      intronic chr14:31033672(+) A-I      intronic chr14:31079671(+) A-I      intronic chr14:31079610(+) A-I      intronic chr14:31071842(+) A-I      intronic chr14:31071838(+) A-I      intronic chr14:31072481(+) A-I      intronic chr14:31079675(+) A-I      intronic chr14:31072428(+) A-I      intronic chr14:31072065(+) A-I      intronic chr14:31072385(+) A-I      intronic chr14:31072381(+) A-I      intronic chr14:31050684(+) A-I      intronic chr14:31050770(+) A-I      intronic chr14:31071973(+) A-I      intronic chr14:31079670(+) A-I      intronic chr14:31072411(+) A-I      intronic chr14:31054155(+) A-I      intronic chr14:31071835(+) A-I      intronic chr14:31033064(+) A-I      intronic chr14:31074159(+) A-I      intronic chr14:31033055(+) A-I      intronic chr14:31071904(+) A-I      intronic chr14:31071935(+) A-I      intronic chr14:31033043(+) A-I      intronic chr14:31072904(+) A-I      intronic chr14:31071873(+) A-I      intronic chr14:31067471(+) A-I      intronic chr14:31074276(+) A-I      intronic chr14:31033651(+) A-I      intronic chr14:31072417(+) A-I      intronic chr14:31071871(+) A-I      intronic chr14:31072380(+) A-I      intronic chr14:31072018(+) A-I      intronic chr14:31072092(+) A-I      intronic chr14:31072477(+) A-I      intronic chr14:31050663(+) A-I      intronic chr14:31079699(+) A-I      intronic chr14:31046280(+) A-I      intronic chr14:31067581(+) A-I      intronic chr14:31072279(+) A-I      intronic chr14:31033044(+) A-I      intronic chr14:31050883(+) A-I      intronic chr14:31071861(+) A-I      intronic chr14:31074242(+) A-I      intronic chr14:31072395(+) A-I      intronic chr14:31067513(+) A-I      intronic chr14:31032982(+) A-I      intronic chr14:31072323(+) A-I      intronic chr14:31072278(+) A-I      intronic chr14:31046320(+) A-I      intronic chr14:31072908(+) A-I      intronic chr14:31054308(+) A-I      intronic chr14:31072052(+) A-I      intronic chr14:31071918(+) A-I      intronic chr14:31072453(+) A-I      intronic chr14:31050704(+) A-I      intronic chr14:31072053(+) A-I      intronic chr14:31071930(+) A-I      intronic chr14:31046269(+) A-I      intronic chr14:31060261(+) A-I      intronic chr14:31071957(+) A-I      intronic chr14:31072992(+) A-I      intronic chr14:31050711(+) A-I      intronic chr14:31072081(+) A-I      intronic chr14:31050635(+) A-I      intronic chr14:31072786(+) A-I      intronic chr14:31072482(+) A-I      intronic chr14:31072382(+) A-I      intronic chr14:31072379(+) A-I      intronic chr14:31072438(+) A-I      intronic chr14:31071879(+) A-I      intronic chr14:31033678(+) A-I      intronic chr14:31033729(+) A-I      intronic chr14:31079750(+) A-I      intronic chr14:31071944(+) A-I      intronic chr14:31086359(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	G2E3	chr14:31080942(+) A-I intron -    22327324 chr14:31080994(+) A-I intron -    22327324 chr14:31064341(+) C-T intron -    22484847 chr14:31071879(+) A-G intron -    22484847 chr14:31072081(+) A-G intron -    22484847 chr14:31072323(+) A-G intron -    22484847 chr14:31072395(+) A-G intron -    22484847 chr14:31072411(+) A-G intron -    22484847 chr14:31080895(+) A-G intron -    22484847 chr14:31080938(+) A-G intron -    22484847 chr14:31080942(+) A-G intron -    22484847 chr14:31080994(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	G2E3	chr14:31072007-31072008(+) m6A exon//intron       24981863 chr14:31072028-31072029(+) m6A exon//intron       24981863 chr14:31072039-31072040(+) m6A exon//intron       24981863 chr14:31084721-31084722(+) m6A CDS//exon       24284625 chr14:31085510-31085511(+) m6A CDS//exon       24284625//22575960//22608085 chr14:31085562-31085563(+) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chr14:31085609-31085610(+) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chr14:31085675-31085676(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr14:31085690-31085691(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr14:31085700-31085701(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr14:31085733-31085734(+) m6A CDS//exon       24209618//24981863//27773535//22608085 chr14:31085753-31085754(+) m6A 3'UTR//exon       24209618//24981863//22608085 chr14:31085828-31085829(+) m6A 3'UTR//exon       24981863//22608085 chr14:31086451-31086452(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr14:31086471-31086472(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr14:31086503-31086504(+) m6A 3'UTR//exon       24981863//22608085 chr14:31086520-31086521(+) m6A 3'UTR//exon       24981863//22608085 chr14:31086852-31086853(+) m6A 3'UTR//exon       27773535 chr14:31087307-31087308(+) m6A 3'UTR//exon       27773535 chr14:31087313-31087314(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	G2E3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART7-3p
Interactor2: G2E3

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.