Basic Information:

  VIRBase ID:  

VHID00321111

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:  MIMAT0003416          PNPO:  NM_018129     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART7-3p	PNPO
miRBase Accession/Entrez ID	MIMAT0003416	55163
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HEL-S-302//PDXPO

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PNPO	chr17:46025270(+) A-I      3'UTR chr17:46025242(+) A-I      3'UTR chr17:46025078(+) A-I      3'UTR chr17:46025154(+) A-I      3'UTR chr17:46025282(+) A-I      3'UTR chr17:46025047(+) A-I      3'UTR chr17:46025034(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PNPO	chr17:46025034(+) A-I exon 3'UTR    15258596 chr17:46025047(+) A-I exon 3'UTR    15258596 chr17:46025078(+) A-I exon 3'UTR    15258596 chr17:46026621(+) T-C intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PNPO	chr17:46018885-46018886(+) m6A 5'UTR       24981863 chr17:46018902-46018903(+) m6A 5'UTR       24981863 chr17:46018909-46018910(+) m6A 5'UTR       24981863 chr17:46018986-46018987(+) m6A 5'UTR//intron       24981863 chr17:46018996-46018997(+) m6A 5'UTR//intron       24981863 chr17:46019138-46019139(+) m6A CDS//intron       24981863 chr17:46019145-46019146(+) m6A CDS//intron       24981863 chr17:46019171-46019172(+) m6A CDS//intron       24981863 chr17:46024028-46024029(+) m6A 3'UTR//CDS//exon       24284625 chr17:46024119-46024120(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:46024135-46024136(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr17:46024155-46024156(+) m6A 3'UTR//exon       24284625//24981863 chr17:46024212-46024213(+) m6A 3'UTR//exon       24284625//24981863 chr17:46024232-46024233(+) m6A 3'UTR//exon       24284625 chr17:46024269-46024270(+) m6A 3'UTR       24284625 chr17:46024757-46024758(+) m6A 3'UTR       24981863 chr17:46024867-46024868(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	PNPO	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART7-3p
Interactor2: PNPO

Evidence Support:

Weak-Evidence	HITS-CLIP
Prediction-Evidence	cRep//miRanda//PITA//Rep//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	Downregulation
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).