Basic Information:

  VIRBase ID:  

VHID00321007

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:  MIMAT0003416          SLC38A2:  NM_018976     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART7-3p	SLC38A2
miRBase Accession/Entrez ID	MIMAT0003416	54407
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ATA2//PRO1068//SAT2//SNAT2

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC38A2	chr12:46752132-46752133(-) m6A 3'UTR       26404942//22575960 chr12:46752142-46752143(-) m6A 3'UTR       26404942//22575960 chr12:46752650-46752651(-) m6A 3'UTR       24284625//26404942//27773535 chr12:46752689-46752690(-) m6A 3'UTR       24284625//26404942//27773535 chr12:46752889-46752890(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:46752923-46752924(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:46752982-46752983(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:46753000-46753001(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr12:46753060-46753061(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:46753138-46753139(-) m6A 3'UTR       24284625//26404942//27773535//22575960 chr12:46753173-46753174(-) m6A 3'UTR       24284625//26404942//27773535//22575960 chr12:46753184-46753185(-) m6A 3'UTR       24284625//26404942//27773535//22575960 chr12:46753207-46753208(-) m6A 3'UTR       26404942//27773535 chr12:46753256-46753257(-) m6A 3'UTR       26404942 chr12:46753296-46753297(-) m6A 3'UTR       26404942 chr12:46754089-46754090(-) m6A 3'UTR       26404942 chr12:46754107-46754108(-) m6A 3'UTR       26404942 chr12:46754140-46754141(-) m6A 3'UTR       26404942 chr12:46754391-46754392(-) m6A 3'UTR       27773535 chr12:46754434-46754435(-) m6A 3'UTR       27773535 chr12:46754468-46754469(-) m6A 3'UTR       27773535 chr12:46754516-46754517(-) m6A 3'UTR       27773535 chr12:46754533-46754534(-) m6A 3'UTR       27773535 chr12:46754624-46754625(-) m6A 3'UTR       24981863//26404942//22575960 chr12:46754678-46754679(-) m6A 3'UTR       24284625//24981863//26404942//22575960 chr12:46754686-46754687(-) m6A 3'UTR       24284625//24981863//26404942//22575960 chr12:46754715-46754716(-) m6A 3'UTR       24284625//24981863//26404942//22575960 chr12:46754746-46754747(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960 chr12:46754841-46754842(-) m6A 3'UTR//exon       24284625//26404942//22575960 chr12:46754872-46754873(-) m6A 3'UTR//exon       24284625//26404942//22575960 chr12:46754878-46754879(-) m6A 3'UTR//exon       24284625//26404942//22575960 chr12:46756074-46756075(-) Am 3'UTR//CDS//exon       - chr12:46758271-46758272(-) m6A 3'UTR//CDS//exon       26404942 chr12:46758278-46758279(-) m6A 3'UTR//CDS//exon       26404942 chr12:46758951-46758952(-) m6A 3'UTR//CDS//exon       22575960 chr12:46760650-46760651(-) m6A 3'UTR//CDS//exon       22575960 chr12:46760664-46760665(-) m6A 3'UTR//CDS//exon       22575960 chr12:46760866-46760867(-) m6A 3'UTR//CDS//exon       22575960 chr12:46760934-46760935(-) m6A 3'UTR//CDS//exon       22575960 chr12:46764607-46764608(-) m6A CDS//exon       22575960 chr12:46764613-46764614(-) m6A CDS//exon       22575960 chr12:46765029-46765030(-) m6A CDS//exon       26404942//27773535//22575960 chr12:46765127-46765128(-) m6A 5'UTR//exon       27773535//22575960 chr12:46766299-46766300(-) m6A 5'UTR//exon       27773535 chr12:46766330-46766331(-) m6A 5'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	SLC38A2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART7-3p
Interactor2: SLC38A2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.