Basic Information:

  VIRBase ID:  

VHID00320443

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:  MIMAT0003416          USP15:  NR_147082     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART7-3p	USP15
miRBase Accession/Entrez ID	MIMAT0003416	9958
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	UNPH-2//UNPH4

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	USP15	chr12:62712847(+) A-I      intronic chr12:62712802(+) A-I      intronic chr12:62679764(+) A-I      intronic chr12:62677509(+) A-I      intronic chr12:62712872(+) A-I      intronic chr12:62714208(+) A-I      intronic chr12:62791435(+) A-I      intronic chr12:62712865(+) A-I      intronic chr12:62714039(+) A-I      intronic chr12:62714238(+) A-I      intronic chr12:62714112(+) A-I      intronic chr12:62714230(+) A-I      intronic chr12:62714213(+) A-I      intronic chr12:62714212(+) A-I      intronic chr12:62712874(+) A-I      intronic chr12:62714209(+) A-I      intronic chr12:62712878(+) A-I      intronic chr12:62712887(+) A-I      intronic chr12:62714188(+) A-I      intronic chr12:62679480(+) A-I      intronic chr12:62679493(+) A-I      intronic chr12:62679530(+) A-I      intronic chr12:62713111(+) A-I      intronic chr12:62713004(+) A-I      intronic chr12:62727335(+) A-I      intronic chr12:62724268(+) A-I      intronic chr12:62724259(+) A-I      intronic chr12:62679531(+) A-I      intronic chr12:62679536(+) A-I      intronic chr12:62679656(+) A-I      intronic chr12:62655824(+) A-I      intronic chr12:62791912(+) A-I      intronic chr12:62791557(+) A-I      intronic chr12:62679657(+) A-I      intronic chr12:62781992(+) A-I      intronic chr12:62675285(+) A-I      intronic chr12:62675329(+) A-I      intronic chr12:62782638(+) A-I      intronic chr12:62788535(+) A-I      intronic chr12:62724330(+) A-I      intronic chr12:62788574(+) A-I      intronic chr12:62788581(+) A-I      intronic chr12:62791486(+) A-I      intronic chr12:62724292(+) A-I      intronic chr12:62791516(+) A-I      intronic chr12:62791846(+) A-I      intronic chr12:62791876(+) A-I      intronic chr12:62791881(+) A-I      intronic chr12:62659501(+) A-I      intronic chr12:62791918(+) A-I      intronic chr12:62692326(+) A-I      intronic chr12:62791936(+) A-I      intronic chr12:62675144(+) A-I      intronic chr12:62692262(+) A-I      intronic chr12:62668014(+) A-I      intronic chr12:62675286(+) A-I      intronic chr12:62724288(+) A-I      intronic chr12:62692379(+) A-I      intronic chr12:62668012(+) A-I      intronic chr12:62724115(+) A-I      intronic chr12:62720657(+) A-I      intronic chr12:62727307(+) A-I      intronic chr12:62727349(+) A-I      intronic chr12:62659564(+) A-I      intronic chr12:62720647(+) A-I      intronic chr12:62656496(+) A-I      intronic chr12:62659502(+) A-I      intronic chr12:62692432(+) A-I      intronic chr12:62663333(+) A-I      intronic chr12:62675218(+) A-I      intronic chr12:62724438(+) A-I      intronic chr12:62727350(+) A-I      intronic chr12:62782069(+) A-I      intronic chr12:62724447(+) A-I      intronic chr12:62724468(+) A-I      intronic chr12:62724640(+) A-I      intronic chr12:62725719(+) A-I      intronic chr12:62727065(+) A-I      intronic chr12:62727134(+) A-I      intronic chr12:62727276(+) A-I      intronic chr12:62720791(+) A-I      intronic chr12:62727320(+) A-I      intronic chr12:62727262(+) A-I      intronic chr12:62741719(+) A-I      intronic chr12:62724429(+) A-I      intronic chr12:62724168(+) A-I      intronic chr12:62720674(+) A-I      intronic chr12:62693031(+) A-I      intronic chr12:62727099(+) A-I      intronic chr12:62657793(+) A-I      intronic chr12:62788482(+) A-I      intronic chr12:62782054(+) A-I      intronic chr12:62727173(+) A-I      intronic chr12:62787401(+) A-I      intronic chr12:62724516(+) A-I      intronic chr12:62782762(+) A-I      intronic chr12:62788457(+) A-I      intronic chr12:62675192(+) A-I      intronic chr12:62782118(+) A-I      intronic chr12:62787450(+) A-I      intronic chr12:62675963(+) A-I      intronic chr12:62771390(+) A-I      intronic chr12:62788531(+) A-I      intronic chr12:62725688(+) A-I      intronic chr12:62727347(+) A-I      intronic chr12:62781934(+) A-I      intronic chr12:62791953(+) A-I      intronic chr12:62724520(+) A-I      intronic chr12:62725799(+) A-I      intronic chr12:62787456(+) A-I      intronic chr12:62725682(+) A-I      intronic chr12:62724141(+) A-I      intronic chr12:62656489(+) A-I      intronic chr12:62781964(+) A-I      intronic chr12:62723157(+) A-I      intronic chr12:62725824(+) A-I      intronic chr12:62787552(+) A-I      intronic chr12:62782751(+) A-I      intronic chr12:62725796(+) A-I      intronic chr12:62668056(+) A-I      intronic chr12:62782174(+) A-I      intronic chr12:62782774(+) A-I      intronic chr12:62791517(+) A-I      intronic chr12:62655998(+) A-I      intronic chr12:62727325(+) A-I      intronic chr12:62782654(+) A-I      intronic chr12:62791401(+) A-I      intronic chr12:62791822(+) A-I      intronic chr12:62791384(+) A-I      intronic chr12:62792040(+) A-I      intronic chr12:62725713(+) A-I      intronic chr12:62727193(+) A-I      intronic chr12:62791479(+) A-I      intronic chr12:62791558(+) A-I      intronic chr12:62791552(+) A-I      intronic chr12:62788437(+) A-I      intronic chr12:62792037(+) A-I      intronic chr12:62782758(+) A-I      intronic chr12:62782815(+) A-I      intronic chr12:62727177(+) A-I      intronic chr12:62791546(+) A-I      intronic chr12:62787542(+) A-I      intronic chr12:62771865(+) A-I      intronic chr12:62781982(+) A-I      intronic chr12:62724171(+) A-I      intronic chr12:62657790(+) A-I      intronic chr12:62727187(+) A-I      intronic chr12:62724604(+) A-I      intronic chr12:62791901(+) A-I      intronic chr12:62787624(+) A-I      intronic chr12:62694979(+) A-I      intronic chr12:62788570(+) A-I      intronic chr12:62725834(+) A-I      intronic chr12:62724473(+) A-I      intronic chr12:62714001(+) A-I      intronic chr12:62781993(+) A-I      intronic chr12:62782187(+) A-I      intronic chr12:62679935(+) A-I      intronic chr12:62791910(+) A-I      intronic chr12:62791436(+) A-I      intronic chr12:62713071(+) A-I      intronic chr12:62725795(+) A-I      intronic chr12:62791543(+) A-I      intronic chr12:62713908(+) A-I      intronic chr12:62791594(+) A-I      intronic chr12:62782727(+) A-I      intronic chr12:62668365(+) A-I      intronic chr12:62677652(+) A-I      intronic chr12:62791947(+) A-I      intronic chr12:62675154(+) A-I      intronic chr12:62787469(+) A-I      intronic chr12:62727078(+) A-I      intronic chr12:62782854(+) A-I      intronic chr12:62791871(+) A-I      intronic chr12:62789681(+) A-I      intronic chr12:62725712(+) A-I      intronic chr12:62680795(+) A-I      intronic chr12:62724114(+) A-I      intronic chr12:62727308(+) A-I      intronic chr12:62724632(+) A-I      intronic chr12:62791872(+) A-I      intronic chr12:62676048(+) A-I      intronic chr12:62675923(+) A-I      intronic chr12:62714113(+) A-I      intronic chr12:62679940(+) A-I      intronic chr12:62712781(+) A-I      intronic chr12:62727133(+) A-I      intronic chr12:62782825(+) A-I      intronic chr12:62656545(+) A-I      intronic chr12:62680162(+) A-I      intronic chr12:62787623(+) A-I      intronic chr12:62787487(+) A-I      intronic chr12:62712820(+) A-I      intronic chr12:62791833(+) A-I      intronic chr12:62787636(+) A-I      intronic chr12:62782013(+) A-I      intronic chr12:62727103(+) A-I      intronic chr12:62712961(+) A-I      intronic chr12:62675141(+) A-I      intronic chr12:62727141(+) A-I      intronic chr12:62782699(+) A-I      intronic chr12:62713067(+) A-I      intronic chr12:62712810(+) A-I      intronic chr12:62727122(+) A-I      intronic chr12:62679881(+) A-I      intronic chr12:62788620(+) A-I      intronic chr12:62782655(+) A-I      intronic chr12:62788374(+) A-I      intronic chr12:62694923(+) A-I      intronic chr12:62712803(+) A-I      intronic chr12:62675198(+) A-I      intronic chr12:62713909(+) A-I      intronic chr12:62791481(+) A-I      intronic chr12:62712960(+) A-I      intronic chr12:62782074(+) A-I      intronic chr12:62680374(+) A-I      intronic chr12:62724560(+) A-I      intronic chr12:62668322(+) A-I      intronic chr12:62709463(+) A-I      intronic chr12:62791812(+) A-I      intronic chr12:62727165(+) A-I      intronic chr12:62782808(+) A-I      intronic chr12:62727260(+) A-I      intronic chr12:62788530(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	USP15	chr12:62712961(+) A-I intron -    22327324 chr12:62727099(+) A-I intron -    22327324 chr12:62782074(+) A-I intron -    21960545   //22327324 chr12:62782762(+) A-I intron -    22327324 chr12:62724640(+) A-I intron -    21960545 chr12:62679881(+) A-G intron -    22484847 chr12:62679935(+) A-G intron -    22484847 chr12:62679940(+) A-G intron -    22484847 chr12:62680162(+) A-G intron -    22484847 chr12:62680374(+) A-G intron -    22484847 chr12:62680795(+) A-G intron -    22484847 chr12:62712781(+) A-G intron -    22484847 chr12:62712803(+) A-G intron -    22484847 chr12:62712810(+) A-G intron -    22484847 chr12:62712960(+) A-G intron -    22484847 chr12:62712961(+) A-G intron -    22484847 chr12:62713067(+) A-G intron -    22484847 chr12:62713071(+) A-G intron -    22484847 chr12:62713909(+) A-G intron -    22484847 chr12:62724114(+) A-G intron -    22484847 chr12:62724552(+) C-A intron -    22484847 chr12:62727099(+) A-G intron -    22484847 chr12:62727103(+) A-G intron -    22484847 chr12:62782074(+) A-G intron -    22484847 chr12:62782118(+) A-G intron -    22484847 chr12:62782727(+) A-G intron -    22484847 chr12:62782758(+) A-G intron -    22484847 chr12:62782815(+) A-G intron -    22484847 chr12:62782890(+) G-C intron -    22484847 chr12:62782891(+) T-A intron -    22484847 chr12:62791552(+) A-G intron -    22484847 chr12:62656489(+) A-G intron -    22484847 chr12:62657790(+) A-G intron -    22484847 chr12:62657793(+) A-G intron -    22484847 chr12:62675141(+) A-G intron -    22484847 chr12:62675154(+) A-G intron -    22484847 chr12:62675192(+) A-G intron -    22484847 chr12:62675198(+) A-G intron -    22484847 chr12:62677652(+) A-G intron -    22484847 chr12:62724604(+) A-G intron -    22484847 chr12:62724632(+) A-G intron -    22484847 chr12:62725688(+) A-G intron -    22484847 chr12:62725712(+) A-G intron -    22484847 chr12:62727133(+) A-G intron -    22484847 chr12:62727141(+) A-G intron -    22484847 chr12:62727165(+) A-G intron -    22484847 chr12:62727173(+) A-G intron -    22484847 chr12:62727177(+) A-G intron -    22484847 chr12:62727193(+) A-G intron -    22484847 chr12:62727308(+) A-G intron -    22484847 chr12:62727325(+) A-G intron -    22484847 chr12:62727347(+) A-G intron -    22484847 chr12:62771865(+) A-G intron -    22484847 chr12:62787401(+) A-G intron -    22484847 chr12:62787469(+) A-G intron -    22484847 chr12:62787487(+) A-G intron -    22484847 chr12:62787515(+) A-C intron -    22484847 chr12:62787608(+) C-T intron -    22484847 chr12:62788437(+) A-G intron -    22484847 chr12:62788530(+) A-G intron -    22484847 chr12:62791384(+) A-G intron -    22484847 chr12:62791436(+) A-G intron -    22484847 chr12:62791479(+) A-G intron -    22484847 chr12:62791481(+) A-G intron -    22484847 chr12:62791812(+) A-G intron -    22484847 chr12:62791833(+) A-G intron -    22484847 chr12:62791871(+) A-G intron -    22484847 chr12:62791872(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	USP15	chr12:62654223-62654224(+) m6A CDS//exon       25456834//24981863//22575960 chr12:62654258-62654259(+) m6A CDS//exon       25456834//24981863//22575960 chr12:62654277-62654278(+) m6A CDS//exon       25456834//24981863//22575960 chr12:62672472-62672473(+) m6A 5'UTR//intron       24981863//22575960 chr12:62698530-62698531(+) m6A exon//intron       27773535 chr12:62698537-62698538(+) m6A exon//intron       27773535 chr12:62698546-62698547(+) m6A exon//intron       27773535 chr12:62698561-62698562(+) m6A exon//intron       27773535 chr12:62698648-62698649(+) m6A exon//intron       27773535 chr12:62775386-62775387(+) m6A CDS//exon       27773535 chr12:62777669-62777670(+) m6A CDS//exon       27773535 chr12:62777679-62777680(+) m6A CDS//exon       27773535 chr12:62777736-62777737(+) m6A CDS//exon       24981863//27773535 chr12:62784705-62784706(+) m6A CDS       27773535 chr12:62784947-62784948(+) m6A CDS       27773535 chr12:62784985-62784986(+) m6A CDS       27773535 chr12:62785005-62785006(+) m6A CDS       27773535 chr12:62795044-62795045(+) m6A 3'UTR//CDS//exon       24284625//22608085 chr12:62798004-62798005(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr12:62798009-62798010(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr12:62798023-62798024(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr12:62798050-62798051(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085 chr12:62798135-62798136(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr12:62798181-62798182(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr12:62798186-62798187(+) Y 3'UTR//exon//intron       26075521 chr12:62798236-62798237(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr12:62798318-62798319(+) m6A 3'UTR//exon//intron       27773535//22608085 chr12:62798329-62798330(+) m6A 3'UTR//exon//intron       27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	USP15	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART7-3p
Interactor2: USP15

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.