Detail Information

Basic Information:


  VIRBase ID:  

VHID00320201

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:           ZNF217:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART7-3p ZNF217
miRBase
Accession/Entrez ID		 MIMAT0003416 7764
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - ZABC1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF217
chr20:52186437(-) A-I      intronic
chr20:52186141(-) A-I      intronic
chr20:52186106(-) A-I      intronic
chr20:52186102(-) A-I      intronic
chr20:52188895(-) A-I      intronic
chr20:52190230(-) A-I      intronic
chr20:52190166(-) A-I      intronic
chr20:52190167(-) A-I      intronic
chr20:52190168(-) A-I      intronic
chr20:52189714(-) A-I      intronic
chr20:52189709(-) A-I      intronic
chr20:52189697(-) A-I      intronic
chr20:52190171(-) A-I      intronic
chr20:52188905(-) A-I      intronic
chr20:52186101(-) A-I      intronic
chr20:52188902(-) A-I      intronic
chr20:52186155(-) A-I      intronic
chr20:52190165(-) A-I      intronic
chr20:52189786(-) A-I      intronic
chr20:52189734(-) A-I      intronic
chr20:52191222(-) A-I      intronic
chr20:52191199(-) A-I      intronic
chr20:52191171(-) A-I      intronic
chr20:52191166(-) A-I      intronic
chr20:52191086(-) A-I      intronic
chr20:52191077(-) A-I      intronic
chr20:52190557(-) A-I      intronic
chr20:52190527(-) A-I      intronic
chr20:52190029(-) A-I      intronic
chr20:52189905(-) A-I      intronic
chr20:52189870(-) A-I      intronic
chr20:52189839(-) A-I      intronic
chr20:52189827(-) A-I      intronic
chr20:52189791(-) A-I      intronic
chr20:52189773(-) A-I      intronic
chr20:52190482(-) A-I      intronic
chr20:52190365(-) A-I      intronic
chr20:52190351(-) A-I      intronic
chr20:52190277(-) A-I      intronic
chr20:52190201(-) A-I      intronic
chr20:52190199(-) A-I      intronic
chr20:52190193(-) A-I      intronic
chr20:52189765(-) A-I      intronic
chr20:52189759(-) A-I      intronic
chr20:52189729(-) A-I      intronic
chr20:52189727(-) A-I      intronic
chr20:52190192(-) A-I      intronic
chr20:52185990(-) A-I      intronic
chr20:52186007(-) A-I      intronic
chr20:52186019(-) A-I      intronic
chr20:52186033(-) A-I      intronic
chr20:52186050(-) A-I      intronic
chr20:52186142(-) A-I      intronic
chr20:52186160(-) A-I      intronic
chr20:52186173(-) A-I      intronic
chr20:52188949(-) A-I      intronic
chr20:52188947(-) A-I      intronic
chr20:52188939(-) A-I      intronic
chr20:52188890(-) A-I      intronic
chr20:52190191(-) A-I      intronic
chr20:52188822(-) A-I      intronic
chr20:52190142(-) A-I      intronic
chr20:52186196(-) A-I      intronic
chr20:52190135(-) A-I      intronic
chr20:52220133(-) A-I      intronic
chr20:52188782(-) A-I      intronic
chr20:52188774(-) A-I      intronic
chr20:52188127(-) A-I      intronic
chr20:52188124(-) A-I      intronic
chr20:52185989(-) A-I      intronic
chr20:52188108(-) A-I      intronic
chr20:52188082(-) A-I      intronic
chr20:52188068(-) A-I      intronic
chr20:52188055(-) A-I      intronic
chr20:52188051(-) A-I      intronic
chr20:52188037(-) A-I      intronic
chr20:52186461(-) A-I      intronic
chr20:52186455(-) A-I      intronic
chr20:52186430(-) A-I      intronic
chr20:52186416(-) A-I      intronic
chr20:52186401(-) A-I      intronic
chr20:52220132(-) A-I      intronic
chr20:52220115(-) A-I      intronic
chr20:52186212(-) A-I      intronic
chr20:52191930(-) A-I      intronic
chr20:52191927(-) A-I      intronic
chr20:52191900(-) A-I      intronic
chr20:52191858(-) A-I      intronic
chr20:52191162(-) A-I      intronic
chr20:52191277(-) A-I      intronic
chr20:52188123(-) A-I      intronic
chr20:52188121(-) A-I      intronic
chr20:52186413(-) A-I      intronic
chr20:52190523(-) A-I      intronic
chr20:52190427(-) A-I      intronic
chr20:52190270(-) A-I      intronic
chr20:52190514(-) A-I      intronic
chr20:52190526(-) A-I      intronic
chr20:52191251(-) A-I      intronic
chr20:52186466(-) A-I      intronic
chr20:52220861(-) A-I      intronic
chr20:52220864(-) A-I      intronic
chr20:52190180(-) A-I      intronic
chr20:52188844(-) A-I      intronic
chr20:52191248(-) A-I      intronic
chr20:52190095(-) A-I      intronic
chr20:52191247(-) A-I      intronic
chr20:52191960(-) A-I      intronic
chr20:52188779(-) A-I      intronic
chr20:52191895(-) A-I      intronic
chr20:52191943(-) A-I      intronic
chr20:52191942(-) A-I      intronic
chr20:52188122(-) A-I      intronic
chr20:52218051(-) A-I      intronic
chr20:52189814(-) A-I      intronic
chr20:52189760(-) A-I      intronic
chr20:52220842(-) A-I      intronic
chr20:52188140(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZNF217
chr20:52190514(-) A-I intron -    22327324
chr20:52190526(-) A-I intron -    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF217
chr20:52183695-52183696(-) m6A 3'UTR       27773535
chr20:52183702-52183703(-) m6A 3'UTR       27773535
chr20:52184806-52184807(-) m6A 3'UTR       27773535
chr20:52184833-52184834(-) m6A 3'UTR       27773535
chr20:52184876-52184877(-) m6A 3'UTR       27773535
chr20:52184974-52184975(-) m6A 3'UTR       24981863//27773535
chr20:52184980-52184981(-) m6A 3'UTR       24981863//27773535
chr20:52185019-52185020(-) m6A 3'UTR       24981863//27773535
chr20:52185086-52185087(-) m6A 3'UTR       24981863
chr20:52185133-52185134(-) Cm 3'UTR       -
chr20:52185580-52185581(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr20:52185596-52185597(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr20:52185605-52185606(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr20:52185615-52185616(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr20:52185670-52185671(-) m6A 3'UTR//CDS       24284625//24981863//28052920//26404942//27773535//22575960//22608085
chr20:52185692-52185693(-) m6A 3'UTR//CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr20:52188287-52188288(-) m6A CDS//intron       27773535
chr20:52188337-52188338(-) m6A CDS//intron       27773535
chr20:52192395-52192396(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr20:52192429-52192430(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:52192545-52192546(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:52192609-52192610(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:52192716-52192717(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr20:52192727-52192728(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr20:52192734-52192735(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr20:52192742-52192743(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr20:52192769-52192770(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr20:52192836-52192837(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr20:52192876-52192877(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr20:52192983-52192984(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:52193068-52193069(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr20:52193077-52193078(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr20:52193112-52193113(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr20:52193147-52193148(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr20:52193247-52193248(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr20:52193294-52193295(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr20:52193375-52193376(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//22575960//22608085
chr20:52193402-52193403(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:52193431-52193432(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:52193452-52193453(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:52193642-52193643(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr20:52193680-52193681(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr20:52193727-52193728(-) m6A CDS       24284625//24981863//28052920//26404942//27773535//27371828//22608085
chr20:52193742-52193743(-) m6A CDS       24284625//24981863//28052920//26404942//27773535//27371828//22608085
chr20:52193768-52193769(-) m6A CDS       24284625//24981863//28052920//27773535//27371828//22608085
chr20:52193811-52193812(-) m6A CDS       24981863//27773535//22608085
chr20:52198166-52198167(-) m6A CDS       25456834//24981863//27371828//27773536
chr20:52198209-52198210(-) m6A CDS       24981863//27773535
chr20:52198309-52198310(-) m6A CDS       27773535
chr20:52198359-52198360(-) m6A CDS       27773535//27371828
chr20:52198549-52198550(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22608085
chr20:52198574-52198575(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr20:52198614-52198615(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr20:52198641-52198642(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr20:52198804-52198805(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr20:52198836-52198837(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr20:52198920-52198921(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr20:52198959-52198960(-) m6A CDS       24284625//24981863//28052920//26404942//27773535//27371828//22608085
chr20:52199017-52199018(-) m6A CDS       24284625//24981863//28052920//27773535//27371828//22608085
chr20:52199022-52199023(-) m6A CDS       24284625//24981863//28052920//27773535//27371828//22608085
chr20:52199083-52199084(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr20:52199119-52199120(-) m6A CDS       24284625//24981863//27773535//22608085
chr20:52199129-52199130(-) m6A CDS       24284625//27773535//22608085
chr20:52199148-52199149(-) m6A CDS       24284625//27773535//22608085
chr20:52199238-52199239(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr20:52199342-52199343(-) m6A CDS       24284625//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:52199377-52199378(-) m6A 5'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr20:52199452-52199453(-) m6A 5'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr20:52199486-52199487(-) m6A 5'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr20:52199505-52199506(-) m6A 5'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr20:52199554-52199555(-) m6A 5'UTR//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr20:52199581-52199582(-) m6A 5'UTR//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr20:52199625-52199626(-) m6A 5'UTR//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr20:52199634-52199635(-) m6A 5'UTR//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr20:52199651-52199652(-) m6A 5'UTR//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr20:52210371-52210372(-) m6A 5'UTR//intron       25456834//24981863//27371828//22608085
chr20:52214190-52214191(-) m6A exon//intron       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BART7-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
ZNF217
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART7-3p
Interactor2: ZNF217

Evidence Support:


Weak-Evidence HITS-CLIP//PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


[1]PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.
[2]PMID 22473208 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression Downregulation
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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