Basic Information:

  VIRBase ID:  

VHID00320029

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6743

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:  MIMAT0003416          RPL5:  NR_146333     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART7-3p	RPL5
miRBase Accession/Entrez ID	MIMAT0003416	6125
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	L5//MSTP030//PPP1R135//uL18

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RPL5	chr1:93305501(+) A-I      intronic chr1:93305497(+) A-I      intronic chr1:93305483(+) A-I      intronic chr1:93305462(+) A-I      intronic chr1:93304818(+) A-I      intronic chr1:93304769(+) A-I      intronic chr1:93305459(+) A-I      intronic chr1:93305417(+) A-I      intronic chr1:93305502(+) A-I      intronic chr1:93305540(+) A-I      intronic chr1:93305510(+) A-I      intronic chr1:93305498(+) A-I      intronic chr1:93305461(+) A-I      intronic chr1:93305454(+) A-I      intronic chr1:93305538(+) A-I      intronic chr1:93304822(+) A-I      intronic chr1:93305843(+) A-I      intronic chr1:93305765(+) A-I      intronic chr1:93304837(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RPL5	chr1:93297659-93297660(+) Cm 5'UTR       - chr1:93298349-93298350(+) m6A exon//intron       27773535 chr1:93298434-93298435(+) m6A exon//intron       27773535 chr1:93298496-93298497(+) m6A exon//intron       27773535 chr1:93299109-93299110(+) m6A 5'UTR//CDS//exon       27773535 chr1:93299197-93299198(+) m6A CDS//exon       27773535//22575960 chr1:93299368-93299369(+) m6A 3'UTR//intron       27773535//22575960 chr1:93299376-93299377(+) m6A 3'UTR//intron       27773535//22575960 chr1:93299463-93299464(+) m6A 3'UTR//intron       27773535 chr1:93300391-93300392(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr1:93301768-93301769(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr1:93301878-93301879(+) m6A 3'UTR//CDS       27773535 chr1:93302197-93302198(+) m6A exon//intron       27773535//22575960 chr1:93302883-93302884(+) Y exon//intron       25219674//26075521 chr1:93302884-93302885(+) Y exon//intron       25219674 chr1:93302887-93302888(+) Y exon//intron       25219674//26075521 chr1:93302965-93302966(+) m6A exon//intron       22575960 chr1:93303147-93303148(+) m6A CDS//exon       24981863//27773535//22575960 chr1:93303170-93303171(+) m6A CDS//exon       24981863//27773535//22575960 chr1:93303185-93303186(+) m6A CDS//exon       24981863//27773535//22575960 chr1:93306305-93306306(+) Gm intron       - chr1:93307327-93307328(+) m6A CDS//exon       24981863//27773535//27371828//22575960//22608085 chr1:93307422-93307423(+) m6A 3'UTR       24981863//27773535//22608085 chr1:93307463-93307464(+) m6A 3'UTR       24981863//27773535//22608085 chr1:93307471-93307472(+) m6A 3'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	RPL5	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART7-3p
Interactor2: RPL5

Evidence Support:

Weak-Evidence	HITS-CLIP//PAR-CLIP
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22473208	Target region	None
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	Downregulation
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).