Basic Information:

  VIRBase ID:  

VHID00319856

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART7-3p:  MIMAT0003416          NFKBIA:  NM_020529     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART7-3p	NFKBIA
miRBase Accession/Entrez ID	MIMAT0003416	4792
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	EDAID2//IKBA//MAD-3//NFKBI

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NFKBIA	chr14:35870732-35870733(-) m6A 3'UTR       27773535 chr14:35870932-35870933(-) m6A 3'UTR       24981863//26404942//27773535 chr14:35870984-35870985(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535 chr14:35870995-35870996(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22608085 chr14:35871038-35871039(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22608085 chr14:35871128-35871129(-) Y 3'UTR       26075521 chr14:35871192-35871193(-) m6A 3'UTR//exon       24284625//24981863//28052920//26404942//27773535//27371828//22608085 chr14:35871198-35871199(-) m6A 3'UTR//exon       24284625//24981863//28052920//26404942//27773535//27371828//22608085 chr14:35871678-35871679(-) m6A 3'UTR//CDS//exon       24284625//26404942//27773535//22575960 chr14:35871828-35871829(-) m6A 3'UTR//CDS//exon//intron       27773535 chr14:35871850-35871851(-) m6A 3'UTR//CDS//exon//intron       27773535 chr14:35872480-35872481(-) m6A 3'UTR//CDS//exon       24284625//27773535//22575960 chr14:35872565-35872566(-) m6A CDS//exon       27773535//22575960 chr14:35872623-35872624(-) m6A exon//intron       27773535 chr14:35872908-35872909(-) m6A CDS//exon//intron       27773535 chr14:35872932-35872933(-) m6A CDS//exon//intron       27773535 chr14:35873151-35873152(-) m6A 5'UTR//intron       - chr14:35873626-35873627(-) m6A CDS//exon       27371828 chr14:35873746-35873747(-) m6A CDS//exon       24284625//26404942//27371828//27773536 chr14:35873786-35873787(-) m1A CDS//exon       26863196//26863410

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	NFKBIA	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART7-3p
Interactor2: NFKBIA

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase//VIRmiRNA

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	Downregulation
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).