Detail Information

Basic Information:


  VIRBase ID:  

VHID00318909

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART6-3p:           DUSP18:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART6-3p DUSP18
miRBase
Accession/Entrez ID		 MIMAT0003415 150290
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - DSP18//DUSP20//LMWDSP20

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DUSP18
chr22:31057533(-) A-I      3'UTR
chr22:31057508(-) A-I      3'UTR
chr22:31058794(-) A-I      3'UTR
chr22:31058766(-) A-I      3'UTR
chr22:31058750(-) A-I      3'UTR
chr22:31058610(-) A-I      3'UTR
chr22:31058609(-) A-I      3'UTR
chr22:31058597(-) A-I      3'UTR
chr22:31058579(-) A-I      3'UTR
chr22:31057564(-) A-I      3'UTR
chr22:31050140(-) A-I      3'UTR
chr22:31058754(-) A-I      3'UTR
chr22:31057434(-) A-I      3'UTR
chr22:31050252(-) A-I      3'UTR
chr22:31058748(-) A-I      3'UTR
chr22:31057488(-) A-I      3'UTR
chr22:31057528(-) A-I      3'UTR
chr22:31058747(-) A-I      3'UTR
chr22:31050176(-) A-I      3'UTR
chr22:31058734(-) A-I      3'UTR
chr22:31057437(-) A-I      3'UTR
chr22:31058697(-) A-I      3'UTR
chr22:31057532(-) A-I      3'UTR
chr22:31057574(-) A-I      3'UTR
chr22:31050166(-) A-I      3'UTR
chr22:31058650(-) A-I      3'UTR
chr22:31050134(-) A-I      3'UTR
chr22:31058646(-) A-I      3'UTR
chr22:31057541(-) A-I      3'UTR
chr22:31057457(-) A-I      3'UTR
chr22:31058631(-) A-I      3'UTR
chr22:31058596(-) A-I      3'UTR
chr22:31058620(-) A-I      3'UTR
chr22:31057547(-) A-I      3'UTR
chr22:31058593(-) A-I      3'UTR
chr22:31057551(-) A-I      3'UTR
chr22:31050238(-) A-I      3'UTR
chr22:31050243(-) A-I      3'UTR
chr22:31057557(-) A-I      3'UTR
chr22:31057568(-) A-I      3'UTR
chr22:31050244(-) A-I      3'UTR
chr22:31057474(-) A-I      3'UTR
chr22:31058592(-) A-I      3'UTR
chr22:31055631(-) A-I      intronic
chr22:31054088(-) A-I      intronic
chr22:31054942(-) A-I      intronic
chr22:31051397(-) A-I      intronic
chr22:31056359(-) A-I      intronic
chr22:31052187(-) A-I      intronic
chr22:31056985(-) A-I      intronic
chr22:31054062(-) A-I      intronic
chr22:31057060(-) A-I      intronic
chr22:31056325(-) A-I      intronic
chr22:31051335(-) A-I      intronic
chr22:31058740(-) A-I      3'UTR
chr22:31058721(-) A-I      3'UTR
chr22:31058692(-) A-I      3'UTR
chr22:31058759(-) A-I      3'UTR
chr22:31058785(-) A-I      3'UTR
chr22:31058733(-) A-I      3'UTR
chr22:31058811(-) A-I      3'UTR
chr22:31058775(-) A-I      3'UTR
chr22:31058783(-) A-I      3'UTR
chr22:31051271(-) A-I      intronic
chr22:31055035(-) A-I      intronic
chr22:31057101(-) A-I      intronic
chr22:31056387(-) A-I      intronic
chr22:31052210(-) A-I      intronic
chr22:31051221(-) A-I      intronic
chr22:31051277(-) A-I      intronic
chr22:31056910(-) A-I      intronic
chr22:31053727(-) A-I      intronic
chr22:31056968(-) A-I      intronic
chr22:31054089(-) A-I      intronic
chr22:31057100(-) A-I      intronic
chr22:31056433(-) A-I      intronic
chr22:31056978(-) A-I      intronic
chr22:31053324(-) A-I      intronic
chr22:31054087(-) A-I      intronic
chr22:31056408(-) A-I      intronic
chr22:31056932(-) A-I      intronic
chr22:31056923(-) A-I      intronic
chr22:31056324(-) A-I      intronic
chr22:31051322(-) A-I      intronic
chr22:31053702(-) A-I      intronic
chr22:31057054(-) A-I      intronic
chr22:31051332(-) A-I      intronic
chr22:31052099(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DUSP18
chr22:31058622(-) A-I exon 3'UTR    15342557
chr22:31058648(-) A-I exon 3'UTR    15342557
chr22:31058692(-) A-I exon 3'UTR    15342557
chr22:31058721(-) A-I exon 3'UTR    15342557
chr22:31058733(-) A-I exon 3'UTR    15342557
chr22:31058740(-) A-I exon 3'UTR    15342557
chr22:31058775(-) A-I exon 3'UTR    15342557
chr22:31058785(-) A-I exon 3'UTR    15342557
chr22:31058811(-) A-I exon 3'UTR    15342557
chr22:31058611(-) A-I exon 3'UTR    22327324
chr22:31058634(-) A-I exon 3'UTR    22327324
chr22:31058694(-) A-I exon 3'UTR    22327324
chr22:31058634(-) A-G exon 3'UTR    21725310
chr22:31058785(-) A-G exon 3'UTR    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DUSP18
chr22:31049910-31049911(-) m6A intron       24981863
chr22:31049938-31049939(-) m6A intron       24981863
chr22:31050283-31050284(-) m6A 3'UTR//intron       24209618//24981863//22608085
chr22:31050348-31050349(-) m6A 3'UTR//intron       24209618//27773535//27371828//22608085
chr22:31057531-31057532(-) m6A 3'UTR//intron       24981863
chr22:31057634-31057635(-) m6A 3'UTR//intron       24209618//25456834//24981863//27773535//22608085
chr22:31057665-31057666(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057677-31057678(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057709-31057710(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057721-31057722(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057776-31057777(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057788-31057789(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057839-31057840(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057875-31057876(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr22:31057914-31057915(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr22:31057975-31057976(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr22:31057998-31057999(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr22:31058154-31058155(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr22:31058299-31058300(-) m6A 3'UTR//intron       24209618//24981863
chr22:31058340-31058341(-) m6A 3'UTR//intron       25456834//24981863//22608085
chr22:31058406-31058407(-) m6A 3'UTR//intron       24284625//25456834//24981863//22608085
chr22:31058456-31058457(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr22:31059097-31059098(-) m6A 3'UTR//intron       24209618//25456834//24981863//22608085
chr22:31059241-31059242(-) m6A 3'UTR//intron       24284625//24209618//24981863//22608085
chr22:31059318-31059319(-) m6A 3'UTR//intron       24209618//24981863//22608085
chr22:31059347-31059348(-) m6A 3'UTR//intron       24209618//24981863//22608085
chr22:31059353-31059354(-) m6A 3'UTR//intron       24209618//24981863//22608085
chr22:31059505-31059506(-) m6A 3'UTR//CDS//intron       24284625//24981863//22608085
chr22:31059590-31059591(-) m6A CDS//intron       24284625//24209618//24981863//22608085
chr22:31059817-31059818(-) m6A CDS//intron       24284625//24209618//24981863//22608085
chr22:31060056-31060057(-) m6A 5'UTR//intron       22608085
chr22:31060984-31060985(-) m6A 5'UTR//intron       -
chr22:31063442-31063443(-) m6A 5'UTR//intron       -
chr22:31063474-31063475(-) m6A 5'UTR//exon       -
chr22:31063722-31063723(-) m6A 5'UTR//exon       27371828
chr22:31063832-31063833(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DUSP18
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART6-3p
Interactor2: DUSP18

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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