Basic Information:

  VIRBase ID:  

VHID00318497

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART6-3p:  MIMAT0003415          AKT1S1:  NM_001278159     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART6-3p	AKT1S1
miRBase Accession/Entrez ID	MIMAT0003415	84335
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	Lobe//PRAS40

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AKT1S1	chr19:50372564-50372565(-) m6A 3'UTR       24284625//27773535 chr19:50372628-50372629(-) m6A 3'UTR       24284625//27773535 chr19:50372809-50372810(-) m6A 3'UTR       27773535 chr19:50372899-50372900(-) Y 3'UTR       25219674//26075521 chr19:50372900-50372901(-) Y 3'UTR       25219674 chr19:50373077-50373078(-) m6A 3'UTR       24284625//27773535 chr19:50374838-50374839(-) m6A CDS       24284625 chr19:50374952-50374953(-) m6A CDS       24284625//24209618//27773535 chr19:50375085-50375086(-) m6A CDS       24284625//24209618//27773535//27371828 chr19:50375109-50375110(-) m6A CDS       24284625//24209618//27773535//27371828 chr19:50376209-50376210(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536 chr19:50376215-50376216(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536 chr19:50376247-50376248(-) m6A CDS       24284625//24209618//27773535//27371828//27773536 chr19:50376482-50376483(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr19:50376673-50376674(-) m6A 5'UTR//intron       25456834//24981863//27773536 chr19:50376691-50376692(-) m6A 5'UTR//intron       25456834//24981863//27773536 chr19:50376733-50376734(-) m6A 5'UTR//intron       25456834//24981863//27773536 chr19:50376882-50376883(-) m6A 5'UTR//intron       27773535 chr19:50376895-50376896(-) m6A 5'UTR//intron       27773535 chr19:50376935-50376936(-) m6A 5'UTR//intron       27773535 chr19:50377206-50377207(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//22608085 chr19:50377227-50377228(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//22608085 chr19:50377267-50377268(-) m6A 5'UTR//intron       24284625//25456834//27371828//22608085 chr19:50377298-50377299(-) m6A 5'UTR//intron       24284625//25456834//27371828//22608085 chr19:50377381-50377382(-) m6A 5'UTR//intron       - chr19:50377550-50377551(-) m6A 5'UTR//intron       24981863 chr19:50377643-50377644(-) m6A 5'UTR//intron       27773536 chr19:50377653-50377654(-) m6A 5'UTR//intron       27773536 chr19:50377663-50377664(-) m6A 5'UTR//intron       27773536 chr19:50380341-50380342(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr19:50380456-50380457(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr19:50380712-50380713(-) m6A 5'UTR//intron       24981863 chr19:50380812-50380813(-) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr19:50380844-50380845(-) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr19:50380888-50380889(-) m6A 5'UTR//intron       24284625//24981863 chr19:50380908-50380909(-) m6A 5'UTR//intron       24284625//24981863 chr19:50381273-50381274(-) m6A 5'UTR//intron       - chr19:50381550-50381551(-) m6A 5'UTR//exon       - chr19:50381578-50381579(-) m6A 5'UTR//exon       - chr19:50381583-50381584(-) m6A 5'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	AKT1S1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART6-3p
Interactor2: AKT1S1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.