Basic Information:

  VIRBase ID:  

VHID00318217

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART6-3p:  MIMAT0003415          DCLRE1C:  NM_001033857     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART6-3p	DCLRE1C
miRBase Accession/Entrez ID	MIMAT0003415	64421
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	A-SCID//DCLREC1C//RS-SCID//SCIDA//SNM1C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCLRE1C	chr10:14948909(-) A-I      3'UTR chr10:14948949(-) A-I      3'UTR chr10:14949969(-) A-I      3'UTR chr10:14949993(-) A-I      3'UTR chr10:14949571(-) A-I      3'UTR chr10:14977001(-) A-I      intronic chr10:14986802(-) A-I      intronic chr10:14986822(-) A-I      intronic chr10:14987754(-) A-I      intronic chr10:14986332(-) A-I      intronic chr10:14952494(-) A-I      intronic chr10:14988136(-) A-I      intronic chr10:14973475(-) A-I      intronic chr10:14972740(-) A-I      intronic chr10:14985116(-) A-I      intronic chr10:14989008(-) A-I      intronic chr10:14974141(-) A-I      intronic chr10:14977344(-) A-I      intronic chr10:14989043(-) A-I      intronic chr10:14976993(-) A-I      intronic chr10:14972648(-) A-I      intronic chr10:14973435(-) A-I      intronic chr10:14989067(-) A-I      intronic chr10:14962869(-) A-I      intronic chr10:14972627(-) A-I      intronic chr10:14972669(-) A-I      intronic chr10:14971281(-) A-I      intronic chr10:14979529(-) A-I      intronic chr10:14972529(-) A-I      intronic chr10:14974393(-) A-I      intronic chr10:14973346(-) A-I      intronic chr10:14972499(-) A-I      intronic chr10:14976992(-) A-I      intronic chr10:14972704(-) A-I      intronic chr10:14979476(-) A-I      intronic chr10:14970890(-) A-I      intronic chr10:14979771(-) A-I      intronic chr10:14972705(-) A-I      intronic chr10:14979471(-) A-I      intronic chr10:14972208(-) A-I      intronic chr10:14972570(-) A-I      intronic chr10:14989181(-) A-I      intronic chr10:14959605(-) A-I      intronic chr10:14959640(-) A-I      intronic chr10:14979510(-) A-I      intronic chr10:14959748(-) A-I      intronic chr10:14988834(-) A-I      intronic chr10:14962762(-) A-I      intronic chr10:14966641(-) A-I      intronic chr10:14979746(-) A-I      intronic chr10:14972231(-) A-I      intronic chr10:14969209(-) A-I      intronic chr10:14976986(-) A-I      intronic chr10:14969303(-) A-I      intronic chr10:14979718(-) A-I      intronic chr10:14972467(-) A-I      intronic chr10:14969332(-) A-I      intronic chr10:14972560(-) A-I      intronic chr10:14985606(-) A-I      intronic chr10:14979446(-) A-I      intronic chr10:14970919(-) A-I      intronic chr10:14971006(-) A-I      intronic chr10:14971030(-) A-I      intronic chr10:14971038(-) A-I      intronic chr10:14972690(-) A-I      intronic chr10:14972396(-) A-I      intronic chr10:14979633(-) A-I      intronic chr10:14974392(-) A-I      intronic chr10:14979696(-) A-I      intronic chr10:14979889(-) A-I      intronic chr10:14985043(-) A-I      intronic chr10:14985741(-) A-I      intronic chr10:14985742(-) A-I      intronic chr10:14979419(-) A-I      intronic chr10:14984958(-) A-I      intronic chr10:14973553(-) A-I      intronic chr10:14986415(-) A-I      intronic chr10:14986949(-) A-I      intronic chr10:14970959(-) A-I      intronic chr10:14987695(-) A-I      intronic chr10:14972462(-) A-I      intronic chr10:14972184(-) A-I      intronic chr10:14973500(-) A-I      intronic chr10:14973494(-) A-I      intronic chr10:14948960(-) A-I      3'UTR chr10:14949957(-) A-I      3'UTR chr10:14949122(-) A-I      3'UTR chr10:14949144(-) A-I      3'UTR chr10:14949006(-) A-I      3'UTR chr10:14949853(-) A-I      3'UTR chr10:14949926(-) A-I      3'UTR chr10:14948996(-) A-I      3'UTR chr10:14949134(-) A-I      3'UTR chr10:14948917(-) A-I      3'UTR chr10:14949982(-) A-I      3'UTR chr10:14950122(-) A-I      3'UTR chr10:14948913(-) A-I      3'UTR chr10:14949958(-) A-I      3'UTR chr10:14949855(-) A-I      3'UTR chr10:14950279(-) A-I      3'UTR chr10:14949972(-) A-I      3'UTR chr10:14948891(-) A-I      3'UTR chr10:14949089(-) A-I      3'UTR chr10:14989170(-) A-I      intronic chr10:14974584(-) A-I      intronic chr10:14973440(-) A-I      intronic chr10:14979562(-) A-I      intronic chr10:14979442(-) A-I      intronic chr10:14972659(-) A-I      intronic chr10:14977382(-) A-I      intronic chr10:14970958(-) A-I      intronic chr10:14946182(-) A-I      intronic chr10:14989149(-) A-I      intronic chr10:14987889(-) A-I      intronic chr10:14959657(-) A-I      intronic chr10:14979382(-) A-I      intronic chr10:14972500(-) A-I      intronic chr10:14986770(-) A-I      intronic chr10:14973377(-) A-I      intronic chr10:14972628(-) A-I      intronic chr10:14986398(-) A-I      intronic chr10:14971584(-) A-I      intronic chr10:14977026(-) A-I      intronic chr10:14971052(-) A-I      intronic chr10:14989103(-) A-I      intronic chr10:14977343(-) A-I      intronic chr10:14989946(-) A-I      intronic chr10:14976997(-) A-I      intronic chr10:14979377(-) A-I      intronic chr10:14979556(-) A-I      intronic chr10:14986911(-) A-I      intronic chr10:14985086(-) A-I      intronic chr10:14989089(-) A-I      intronic chr10:14977341(-) A-I      intronic chr10:14979810(-) A-I      intronic chr10:14988186(-) A-I      intronic chr10:14989095(-) A-I      intronic chr10:14976989(-) A-I      intronic chr10:14959630(-) A-I      intronic chr10:14988183(-) A-I      intronic chr10:14989055(-) A-I      intronic chr10:14977316(-) A-I      intronic chr10:14979509(-) A-I      intronic chr10:14974394(-) A-I      intronic chr10:14985749(-) A-I      intronic chr10:14976998(-) A-I      intronic chr10:14972534(-) A-I      intronic chr10:14989066(-) A-I      intronic chr10:14979698(-) A-I      intronic chr10:14970946(-) A-I      intronic chr10:14973445(-) A-I      intronic chr10:14986416(-) A-I      intronic chr10:14988816(-) A-I      intronic chr10:14986853(-) A-I      intronic chr10:14971021(-) A-I      intronic chr10:14959566(-) A-I      intronic chr10:14959739(-) A-I      intronic chr10:14988288(-) A-I      intronic chr10:14976995(-) A-I      intronic chr10:14969302(-) A-I      intronic chr10:14946121(-) A-I      intronic chr10:14971029(-) A-I      intronic chr10:14988124(-) A-I      intronic chr10:14985110(-) A-I      intronic chr10:14979639(-) A-I      intronic chr10:14979724(-) A-I      intronic chr10:14979824(-) A-I      intronic chr10:14979370(-) A-I      intronic chr10:14985787(-) A-I      intronic chr10:14979742(-) A-I      intronic chr10:14972691(-) A-I      intronic chr10:14970922(-) A-I      intronic chr10:14972383(-) A-I      intronic chr10:14972378(-) A-I      intronic chr10:14972524(-) A-I      intronic chr10:14989111(-) A-I      intronic chr10:14943779(-) A-I      intronic chr10:14979811(-) A-I      intronic chr10:14985016(-) A-I      intronic chr10:14950273(-) A-I      3'UTR chr10:14948890(-) A-I      3'UTR chr10:14950117(-) A-I      3'UTR chr10:14949121(-) A-I      3'UTR chr10:14949989(-) A-I      3'UTR chr10:14986851(-) A-I      intronic chr10:14950077(-) A-I      3'UTR chr10:14948989(-) A-I      3'UTR chr10:14950021(-) A-I      3'UTR chr10:14948950(-) A-I      3'UTR chr10:14986870(-) A-I      intronic chr10:14949135(-) A-I      3'UTR chr10:14949928(-) A-I      3'UTR chr10:14973518(-) A-I      intronic chr10:14948965(-) A-I      3'UTR chr10:14949999(-) A-I      3'UTR chr10:14959733(-) A-I      intronic chr10:14949977(-) A-I      3'UTR chr10:14949998(-) A-I      3'UTR chr10:14949037(-) A-I      3'UTR chr10:14988741(-) A-I      intronic chr10:14949985(-) A-I      3'UTR chr10:14949138(-) A-I      3'UTR chr10:14949976(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DCLRE1C	chr10:14988124(-) A-I intron -    22327324 chr10:14972524(-) A-I intron -    22028664 chr10:14972560(-) A-I intron -    22028664 chr10:14972570(-) A-I intron -    22028664 chr10:14972596(-) A-I intron -    22028664 chr10:14972627(-) A-I intron -    22028664 chr10:14972628(-) A-I intron -    22028664 chr10:14972648(-) A-I intron -    22028664 chr10:14972659(-) A-I intron -    22028664 chr10:14972690(-) A-I intron -    22028664 chr10:14972691(-) A-I intron -    22028664 chr10:14972704(-) A-I intron -    22028664 chr10:14972705(-) A-I intron -    22028664 chr10:14972740(-) A-I intron -    22028664 chr10:14949006(-) A-I exon 3'UTR    21960545 chr10:14949134(-) A-I exon 3'UTR    21960545 chr10:14949135(-) A-I exon 3'UTR    21960545 chr10:14950122(-) A-I exon 3'UTR    21960545 chr10:14948942(-) T-C exon 3'UTR    22484847 chr10:14948997(-) T-C exon 3'UTR    22484847 chr10:14949006(-) A-G exon 3'UTR    22484847 chr10:14949007(-) T-C exon 3'UTR    22484847 chr10:14949856(-) G-A exon 3'UTR    22484847 chr10:14949976(-) A-G exon 3'UTR    22484847 chr10:14949989(-) A-G exon 3'UTR    22484847 chr10:14949998(-) A-G exon 3'UTR    22484847 chr10:14949999(-) A-G exon 3'UTR    22484847 chr10:14950021(-) A-G exon 3'UTR    22484847 chr10:14950279(-) A-G exon 3'UTR    22484847 chr10:14952503(-) T-C intron -    22484847 chr10:14956759(-) T-C intron -    22484847 chr10:14956776(-) T-C intron -    22484847 chr10:14985606(-) A-G intron -    22484847 chr10:14988124(-) A-G intron -    22484847 chr10:14988186(-) A-G intron -    22484847 chr10:14988741(-) A-G intron -    22484847 chr10:14989170(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCLRE1C	chr10:14939374-14939375(-) m6A 3'UTR       24284625//24209618//24981863//22608085 chr10:14939383-14939384(-) m6A 3'UTR       24284625//24209618//24981863//22608085 chr10:14939491-14939492(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr10:14939521-14939522(-) m6A 3'UTR       24209618//24981863//22608085 chr10:14939558-14939559(-) m6A 3'UTR       24209618//24981863//22608085 chr10:14941006-14941007(-) m6A 3'UTR       - chr10:14941030-14941031(-) m6A 3'UTR       - chr10:14941113-14941114(-) m6A 3'UTR       - chr10:14948905-14948906(-) m6A intron       27773535 chr10:14948948-14948949(-) m6A intron       27773535 chr10:14949025-14949026(-) m6A intron       27773535 chr10:14949052-14949053(-) m6A intron       24209618//27773535 chr10:14949188-14949189(-) m6A intron       24209618//24981863//27773535//22608085 chr10:14949269-14949270(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949283-14949284(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949303-14949304(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949326-14949327(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949357-14949358(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949391-14949392(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949405-14949406(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949448-14949449(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949483-14949484(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949541-14949542(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949555-14949556(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949612-14949613(-) m6A intron       24284625//24209618//24981863//27773535//22608085 chr10:14949651-14949652(-) m6A intron       24284625//24209618//24981863//27773535//22608085 chr10:14949678-14949679(-) m6A intron       24284625//24209618//24981863//27773535//22608085 chr10:14949687-14949688(-) m6A intron       24284625//24209618//24981863//27773535//22608085 chr10:14949762-14949763(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949773-14949774(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949833-14949834(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949838-14949839(-) m6A intron       24284625//24981863//27773535//22608085 chr10:14949886-14949887(-) m6A 3'UTR//intron       24284625//27773535//22608085 chr10:14949956-14949957(-) m6A 3'UTR//intron       24981863 chr10:14950045-14950046(-) m6A 3'UTR//intron       24209618//24981863 chr10:14950367-14950368(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr10:14950603-14950604(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr10:14950625-14950626(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr10:14950709-14950710(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr10:14950748-14950749(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:14950764-14950765(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:14950788-14950789(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:14950830-14950831(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:14950850-14950851(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:14950968-14950969(-) m6A CDS//exon//intron       24981863//27773535//22608085 chr10:14951142-14951143(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr10:14951191-14951192(-) m6A CDS//exon//intron       25456834//24981863 chr10:14951195-14951196(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr10:14951201-14951202(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr10:14951257-14951258(-) m6A CDS//exon//intron       24284625//24981863//27773535//27371828//22608085 chr10:14953204-14953205(-) m6A exon//intron       22608085 chr10:14953209-14953210(-) m6A exon//intron       22608085 chr10:14953215-14953216(-) m6A exon//intron       22608085 chr10:14961741-14961742(-) m6A CDS//exon       22608085 chr10:14961754-14961755(-) m6A CDS//exon       22608085 chr10:14961770-14961771(-) m6A CDS//exon       22608085 chr10:14961782-14961783(-) m6A CDS//exon       22608085 chr10:14989599-14989600(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DCLRE1C	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART6-3p
Interactor2: DCLRE1C

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.