Basic Information:

  VIRBase ID:  

VHID00318043

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART6-3p:  MIMAT0003415          TOMM22:  NM_020243     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART6-3p	TOMM22
miRBase Accession/Entrez ID	MIMAT0003415	56993
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	1C9-2//MST065//MSTP065//TOM22

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TOMM22	chr22:39078018-39078019(+) m6A CDS       25456834//24981863//27371828//27773536 chr22:39078305-39078306(+) m6A exon//intron       24981863 chr22:39078336-39078337(+) m6A CDS//exon       24981863 chr22:39078350-39078351(+) m6A CDS//exon       24981863 chr22:39079903-39079904(+) m6A 3'UTR//exon       24284625//24981863 chr22:39079960-39079961(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr22:39080001-39080002(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr22:39080161-39080162(+) m6A 3'UTR//exon       24981863 chr22:39080247-39080248(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr22:39080265-39080266(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr22:39080364-39080365(+) m6A 3'UTR       24981863//27773535//22608085 chr22:39080374-39080375(+) m6A 3'UTR       24981863//27773535//22608085 chr22:39080414-39080415(+) m6A 3'UTR       24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TOMM22	Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART6-3p
Interactor2: TOMM22

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.