Basic Information:

  VIRBase ID:  

VHID00317568

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART6-3p:  MIMAT0003415          WWTR1:  NM_001348362     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART6-3p	WWTR1
miRBase Accession/Entrez ID	MIMAT0003415	25937
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	TAZ

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WWTR1	chr3:149241229(-) A-I      intronic chr3:149241242(-) A-I      intronic chr3:149241272(-) A-I      intronic chr3:149360155(-) A-I      intronic chr3:149351060(-) A-I      intronic chr3:149416286(-) A-I      intronic chr3:149416274(-) A-I      intronic chr3:149416273(-) A-I      intronic chr3:149345821(-) A-I      intronic chr3:149286051(-) A-I      intronic chr3:149248910(-) A-I      intronic chr3:149248925(-) A-I      intronic chr3:149255812(-) A-I      intronic chr3:149255818(-) A-I      intronic chr3:149255845(-) A-I      intronic chr3:149255861(-) A-I      intronic chr3:149255874(-) A-I      intronic chr3:149275031(-) A-I      intronic chr3:149248899(-) A-I      intronic chr3:149275033(-) A-I      intronic chr3:149275034(-) A-I      intronic chr3:149275036(-) A-I      intronic chr3:149275052(-) A-I      intronic chr3:149275063(-) A-I      intronic chr3:149241238(-) A-I      intronic chr3:149248889(-) A-I      intronic chr3:149275072(-) A-I      intronic chr3:149275086(-) A-I      intronic chr3:149326770(-) A-I      intronic chr3:149326781(-) A-I      intronic chr3:149326806(-) A-I      intronic chr3:149328686(-) A-I      intronic chr3:149369689(-) A-I      intronic chr3:149369693(-) A-I      intronic chr3:149380933(-) A-I      intronic chr3:149380936(-) A-I      intronic chr3:149380943(-) A-I      intronic chr3:149380948(-) A-I      intronic chr3:149380973(-) A-I      intronic chr3:149248890(-) A-I      intronic chr3:149248891(-) A-I      intronic chr3:149248897(-) A-I      intronic chr3:149241267(-) A-I      intronic chr3:149416248(-) A-I      intronic chr3:149416245(-) A-I      intronic chr3:149428584(-) A-I      intronic chr3:149428579(-) A-I      intronic chr3:149428531(-) A-I      intronic chr3:149380992(-) A-I      intronic chr3:149416261(-) A-I      intronic chr3:149237592(-) A-I      3'UTR chr3:149237566(-) A-I      3'UTR chr3:149237544(-) A-I      3'UTR chr3:149237563(-) A-I      3'UTR chr3:149237572(-) A-I      3'UTR chr3:149237582(-) A-I      3'UTR chr3:149237608(-) A-I      3'UTR chr3:149237543(-) A-I      3'UTR chr3:149312834(-) A-I      intronic chr3:149312845(-) A-I      intronic chr3:149312846(-) A-I      intronic chr3:149312854(-) A-I      intronic chr3:149312973(-) A-I      intronic chr3:149275022(-) A-I      intronic chr3:149275047(-) A-I      intronic chr3:149275150(-) A-I      intronic chr3:149275598(-) A-I      intronic chr3:149275673(-) A-I      intronic chr3:149355309(-) A-I      intronic chr3:149275675(-) A-I      intronic chr3:149275707(-) A-I      intronic chr3:149282898(-) A-I      intronic chr3:149283612(-) A-I      intronic chr3:149285938(-) A-I      intronic chr3:149290513(-) A-I      intronic chr3:149355895(-) A-I      intronic chr3:149355903(-) A-I      intronic chr3:149355916(-) A-I      intronic chr3:149357050(-) A-I      intronic chr3:149357267(-) A-I      intronic chr3:149358307(-) A-I      intronic chr3:149358340(-) A-I      intronic chr3:149358345(-) A-I      intronic chr3:149358372(-) A-I      intronic chr3:149360395(-) A-I      intronic chr3:149360398(-) A-I      intronic chr3:149360462(-) A-I      intronic chr3:149360475(-) A-I      intronic chr3:149360560(-) A-I      intronic chr3:149362722(-) A-I      intronic chr3:149362777(-) A-I      intronic chr3:149362778(-) A-I      intronic chr3:149363031(-) A-I      intronic chr3:149363044(-) A-I      intronic chr3:149366917(-) A-I      intronic chr3:149369652(-) A-I      intronic chr3:149369654(-) A-I      intronic chr3:149369655(-) A-I      intronic chr3:149369919(-) A-I      intronic chr3:149370163(-) A-I      intronic chr3:149370406(-) A-I      intronic chr3:149372654(-) A-I      intronic chr3:149372657(-) A-I      intronic chr3:149372658(-) A-I      intronic chr3:149372721(-) A-I      intronic chr3:149372850(-) A-I      intronic chr3:149373123(-) A-I      intronic chr3:149373145(-) A-I      intronic chr3:149373149(-) A-I      intronic chr3:149373185(-) A-I      intronic chr3:149373224(-) A-I      intronic chr3:149373225(-) A-I      intronic chr3:149423907(-) A-I      intronic chr3:149424308(-) A-I      intronic chr3:149427457(-) A-I      intronic chr3:149433925(-) A-I      intronic chr3:149433926(-) A-I      intronic chr3:149433927(-) A-I      intronic chr3:149445457(-) A-I      intronic chr3:149290577(-) A-I      intronic chr3:149291934(-) A-I      intronic chr3:149291942(-) A-I      intronic chr3:149298674(-) A-I      intronic chr3:149300340(-) A-I      intronic chr3:149300396(-) A-I      intronic chr3:149247994(-) A-I      intronic chr3:149248854(-) A-I      intronic chr3:149300460(-) A-I      intronic chr3:149251845(-) A-I      intronic chr3:149251894(-) A-I      intronic chr3:149300479(-) A-I      intronic chr3:149251900(-) A-I      intronic chr3:149253786(-) A-I      intronic chr3:149274893(-) A-I      intronic chr3:149240561(-) A-I      intronic chr3:149312783(-) A-I      intronic chr3:149335582(-) A-I      intronic chr3:149337374(-) A-I      intronic chr3:149342615(-) A-I      intronic chr3:149342624(-) A-I      intronic chr3:149342625(-) A-I      intronic chr3:149343085(-) A-I      intronic chr3:149343105(-) A-I      intronic chr3:149343155(-) A-I      intronic chr3:149343172(-) A-I      intronic chr3:149343348(-) A-I      intronic chr3:149343430(-) A-I      intronic chr3:149343434(-) A-I      intronic chr3:149343466(-) A-I      intronic chr3:149343478(-) A-I      intronic chr3:149343542(-) A-I      intronic chr3:149346841(-) A-I      intronic chr3:149346849(-) A-I      intronic chr3:149346851(-) A-I      intronic chr3:149347836(-) A-I      intronic chr3:149349941(-) A-I      intronic chr3:149355221(-) A-I      intronic chr3:149355245(-) A-I      intronic chr3:149355293(-) A-I      intronic chr3:149355299(-) A-I      intronic chr3:149240580(-) A-I      intronic chr3:149240581(-) A-I      intronic chr3:149240619(-) A-I      intronic chr3:149241108(-) A-I      intronic chr3:149241156(-) A-I      intronic chr3:149244969(-) A-I      intronic chr3:149245176(-) A-I      intronic chr3:149245198(-) A-I      intronic chr3:149245206(-) A-I      intronic chr3:149245207(-) A-I      intronic chr3:149247890(-) A-I      intronic chr3:149247900(-) A-I      intronic chr3:149247909(-) A-I      intronic chr3:149247970(-) A-I      intronic chr3:149274963(-) A-I      intronic chr3:149274968(-) A-I      intronic chr3:149274989(-) A-I      intronic chr3:149312981(-) A-I      intronic chr3:149313014(-) A-I      intronic chr3:149313636(-) A-I      intronic chr3:149326203(-) A-I      intronic chr3:149326279(-) A-I      intronic chr3:149326284(-) A-I      intronic chr3:149240567(-) A-I      intronic chr3:149326393(-) A-I      intronic chr3:149326413(-) A-I      intronic chr3:149326619(-) A-I      intronic chr3:149326622(-) A-I      intronic chr3:149326732(-) A-I      intronic chr3:149326734(-) A-I      intronic chr3:149326761(-) A-I      intronic chr3:149326780(-) A-I      intronic chr3:149326799(-) A-I      intronic chr3:149326809(-) A-I      intronic chr3:149326830(-) A-I      intronic chr3:149326854(-) A-I      intronic chr3:149328685(-) A-I      intronic chr3:149328712(-) A-I      intronic chr3:149328725(-) A-I      intronic chr3:149328737(-) A-I      intronic chr3:149328819(-) A-I      intronic chr3:149328889(-) A-I      intronic chr3:149331431(-) A-I      intronic chr3:149331491(-) A-I      intronic chr3:149331612(-) A-I      intronic chr3:149335580(-) A-I      intronic chr3:149274990(-) A-I      intronic chr3:149326392(-) A-I      intronic chr3:149248819(-) A-I      intronic chr3:149369713(-) A-I      intronic chr3:149326817(-) A-I      intronic chr3:149369728(-) A-I      intronic chr3:149445488(-) A-I      intronic chr3:149300418(-) A-I      intronic chr3:149253753(-) A-I      intronic chr3:149431440(-) A-I      intronic chr3:149345678(-) A-I      intronic chr3:149313806(-) A-I      intronic chr3:149350984(-) A-I      intronic chr3:149373014(-) A-I      intronic chr3:149345698(-) A-I      intronic chr3:149312967(-) A-I      intronic chr3:149402089(-) A-I      intronic chr3:149246520(-) A-I      intronic chr3:149358275(-) A-I      intronic chr3:149328687(-) A-I      intronic chr3:149253617(-) A-I      intronic chr3:149241103(-) A-I      intronic chr3:149369738(-) A-I      intronic chr3:149358480(-) A-I      intronic chr3:149248901(-) A-I      intronic chr3:149291925(-) A-I      intronic chr3:149331473(-) A-I      intronic chr3:149369850(-) A-I      intronic chr3:149313019(-) A-I      intronic chr3:149417352(-) A-I      intronic chr3:149358489(-) A-I      intronic chr3:149347731(-) A-I      intronic chr3:149335541(-) A-I      intronic chr3:149240579(-) A-I      intronic chr3:149402489(-) A-I      intronic chr3:149444417(-) A-I      intronic chr3:149370167(-) A-I      intronic chr3:149357270(-) A-I      intronic chr3:149343177(-) A-I      intronic chr3:149434701(-) A-I      intronic chr3:149363238(-) A-I      intronic chr3:149369714(-) A-I      intronic chr3:149331579(-) A-I      intronic chr3:149251782(-) A-I      intronic chr3:149357591(-) A-I      intronic chr3:149313814(-) A-I      intronic chr3:149246480(-) A-I      intronic chr3:149248860(-) A-I      intronic chr3:149312992(-) A-I      intronic chr3:149370261(-) A-I      intronic chr3:149331575(-) A-I      intronic chr3:149312922(-) A-I      intronic chr3:149319184(-) A-I      intronic chr3:149343089(-) A-I      intronic chr3:149431347(-) A-I      intronic chr3:149445396(-) A-I      intronic chr3:149355881(-) A-I      intronic chr3:149346689(-) A-I      intronic chr3:149445404(-) A-I      intronic chr3:149370205(-) A-I      intronic chr3:149445315(-) A-I      intronic chr3:149313631(-) A-I      intronic chr3:149342584(-) A-I      intronic chr3:149326337(-) A-I      intronic chr3:149445363(-) A-I      intronic chr3:149251789(-) A-I      intronic chr3:149346685(-) A-I      intronic chr3:149346758(-) A-I      intronic chr3:149312975(-) A-I      intronic chr3:149334517(-) A-I      intronic chr3:149301224(-) A-I      intronic chr3:149360200(-) A-I      intronic chr3:149345695(-) A-I      intronic chr3:149448893(-) A-I      intronic chr3:149347812(-) A-I      intronic chr3:149370348(-) A-I      intronic chr3:149343131(-) A-I      intronic chr3:149240661(-) A-I      intronic chr3:149326842(-) A-I      intronic chr3:149448894(-) A-I      intronic chr3:149346831(-) A-I      intronic chr3:149283611(-) A-I      intronic chr3:149275075(-) A-I      intronic chr3:149326319(-) A-I      intronic chr3:149363218(-) A-I      intronic chr3:149286832(-) A-I      intronic chr3:149445398(-) A-I      intronic chr3:149248964(-) A-I      intronic chr3:149428527(-) A-I      intronic chr3:149346786(-) A-I      intronic chr3:149373186(-) A-I      intronic chr3:149367487(-) A-I      intronic chr3:149358276(-) A-I      intronic chr3:149431441(-) A-I      intronic chr3:149240667(-) A-I      intronic chr3:149248806(-) A-I      intronic chr3:149360085(-) A-I      intronic chr3:149444283(-) A-I      intronic chr3:149369835(-) A-I      intronic chr3:149287657(-) A-I      intronic chr3:149445302(-) A-I      intronic chr3:149240769(-) A-I      intronic chr3:149343390(-) A-I      intronic chr3:149313809(-) A-I      intronic chr3:149331380(-) A-I      intronic chr3:149286825(-) A-I      intronic chr3:149369894(-) A-I      intronic chr3:149286826(-) A-I      intronic chr3:149413732(-) A-I      intronic chr3:149240741(-) A-I      intronic chr3:149331514(-) A-I      intronic chr3:149331559(-) A-I      intronic chr3:149240731(-) A-I      intronic chr3:149343532(-) A-I      intronic chr3:149240790(-) A-I      intronic chr3:149343333(-) A-I      intronic chr3:149444569(-) A-I      intronic chr3:149347914(-) A-I      intronic chr3:149287661(-) A-I      intronic chr3:149251767(-) A-I      intronic chr3:149369825(-) A-I      intronic chr3:149316380(-) A-I      intronic chr3:149313662(-) A-I      intronic chr3:149358435(-) A-I      intronic chr3:149402642(-) A-I      intronic chr3:149241291(-) A-I      intronic chr3:149248099(-) A-I      intronic chr3:149359963(-) A-I      intronic chr3:149370160(-) A-I      intronic chr3:149444284(-) A-I      intronic chr3:149288207(-) A-I      intronic chr3:149281720(-) A-I      intronic chr3:149369897(-) A-I      intronic chr3:149248072(-) A-I      intronic chr3:149291946(-) A-I      intronic chr3:149312887(-) A-I      intronic chr3:149274930(-) A-I      intronic chr3:149340886(-) A-I      intronic chr3:149253634(-) A-I      intronic chr3:149248133(-) A-I      intronic chr3:149240801(-) A-I      intronic chr3:149316365(-) A-I      intronic chr3:149275096(-) A-I      intronic chr3:149331463(-) A-I      intronic chr3:149288193(-) A-I      intronic chr3:149369751(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WWTR1	chr3:149344948(-) A-I intron -    21960545 chr3:149246480(-) A-G intron -    22484847 chr3:149275662(-) A-G intron -    22484847 chr3:149313809(-) A-G intron -    22484847 chr3:149313814(-) A-G intron -    22484847 chr3:149326306(-) T-C intron -    22484847 chr3:149326329(-) G-A intron -    22484847 chr3:149345695(-) A-G intron -    22484847 chr3:149357270(-) A-G intron -    22484847 chr3:149358435(-) A-G intron -    22484847 chr3:149370377(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WWTR1	chr3:149235703-149235704(-) m6A 3'UTR       27773535 chr3:149235813-149235814(-) m6A 3'UTR       27773535 chr3:149235883-149235884(-) m6A 3'UTR       27773535 chr3:149235962-149235963(-) m6A 3'UTR       27773535 chr3:149236009-149236010(-) m6A 3'UTR       27773535 chr3:149236415-149236416(-) m6A 3'UTR       24981863//27773535 chr3:149236474-149236475(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr3:149236561-149236562(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr3:149236601-149236602(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr3:149236634-149236635(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr3:149236660-149236661(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr3:149237020-149237021(-) m6A 3'UTR       26404942 chr3:149237204-149237205(-) m6A 3'UTR       26404942 chr3:149238409-149238410(-) m6A 3'UTR       27773535 chr3:149238622-149238623(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535 chr3:149238661-149238662(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085 chr3:149238677-149238678(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085 chr3:149238695-149238696(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085 chr3:149238731-149238732(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085 chr3:149238748-149238749(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085 chr3:149238758-149238759(-) m6A 3'UTR//CDS       27773535 chr3:149238762-149238763(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085 chr3:149245667-149245668(-) m6A 3'UTR//CDS//exon       26404942//27773535 chr3:149245716-149245717(-) m6A 3'UTR//CDS//exon       27773535 chr3:149258815-149258816(-) m6A CDS//intron       27773535 chr3:149258833-149258834(-) m6A CDS//intron       26404942 chr3:149260190-149260191(-) m6A CDS//exon       24284625//24981863//26404942 chr3:149260254-149260255(-) m6A CDS       24284625//24981863//26404942//27773535 chr3:149260269-149260270(-) m6A CDS       24284625//24981863//26404942//27773535 chr3:149290718-149290719(-) m6A CDS       24284625//24981863//26404942//27773535 chr3:149290757-149290758(-) m6A CDS       24284625//26404942//27773535 chr3:149293871-149293872(-) m6A 5'UTR//intron       24284625//27773535 chr3:149375013-149375014(-) m6A CDS       24284625//27773536 chr3:149375019-149375020(-) m6A CDS       24284625//27773536 chr3:149375025-149375026(-) m6A CDS       24284625//27773536 chr3:149375637-149375638(-) m6A 5'UTR//intron       24284625//24981863 chr3:149375704-149375705(-) m6A 5'UTR//intron       24284625//24981863 chr3:149375813-149375814(-) m6A 5'UTR//intron       24284625//24981863 chr3:149375827-149375828(-) m6A 5'UTR//intron       24284625//24981863 chr3:149420630-149420631(-) m6A exon//intron       27773535 chr3:149420663-149420664(-) m6A exon//intron       27773535 chr3:149420710-149420711(-) m6A exon//intron       27773535 chr3:149420934-149420935(-) m6A 5'UTR//exon       27773535 chr3:149420968-149420969(-) m6A 5'UTR//exon       27773535 chr3:149421026-149421027(-) m6A 5'UTR//exon       27773535 chr3:149421034-149421035(-) m6A 5'UTR//exon       27773535 chr3:149421086-149421087(-) m6A exon       27773535 chr3:149421108-149421109(-) m6A exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	WWTR1	Cytosol HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART6-3p
Interactor2: WWTR1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.