Detail Information

Basic Information:


  VIRBase ID:  

VHID00317213

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART6-3p:           TRIB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART6-3p TRIB1
miRBase
Accession/Entrez ID		 MIMAT0003415 10221
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - C8FW//GIG-2//GIG2//SKIP1//TRB-1//TRB1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIB1
chr8:126447778(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIB1
chr8:126442717-126442718(+) m6A 5'UTR       24284625//24981863
chr8:126442790-126442791(+) m6A 5'UTR       24284625//25456834//24981863
chr8:126442835-126442836(+) m6A 5'UTR       25456834//24981863
chr8:126442914-126442915(+) m6A 5'UTR       25456834//24981863
chr8:126443022-126443023(+) m6A 5'UTR       24284625//25456834//24981863//22575960
chr8:126443034-126443035(+) m6A 5'UTR       24284625//25456834//24981863//22575960
chr8:126443077-126443078(+) m6A 5'UTR       24284625//25456834//24981863//26404942//22575960
chr8:126443108-126443109(+) m6A 5'UTR       24284625//25456834//24981863//26404942//22575960
chr8:126443316-126443317(+) m6A CDS       24209618
chr8:126445572-126445573(+) m6A 5'UTR//CDS//exon       24284625//24981863//22608085
chr8:126445583-126445584(+) m6A 5'UTR//CDS//exon       24284625//24981863//22608085
chr8:126445657-126445658(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22608085
chr8:126445685-126445686(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22608085
chr8:126445694-126445695(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22608085
chr8:126445811-126445812(+) m6A 5'UTR//CDS//exon       24284625//25456834//24981863
chr8:126445889-126445890(+) m6A 5'UTR//intron       24284625//24981863
chr8:126445940-126445941(+) m6A 5'UTR//intron       24284625//24981863
chr8:126448259-126448260(+) m6A 5'UTR//CDS       24284625//24209618//24981863//22608085
chr8:126448276-126448277(+) m6A 5'UTR//CDS       24284625//24209618//24981863//22608085
chr8:126448315-126448316(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448368-126448369(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448456-126448457(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448490-126448491(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448571-126448572(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448622-126448623(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448650-126448651(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448657-126448658(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448684-126448685(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448721-126448722(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448730-126448731(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448774-126448775(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448833-126448834(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr8:126448936-126448937(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr8:126449000-126449001(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr8:126449033-126449034(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr8:126449143-126449144(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr8:126449162-126449163(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:126449267-126449268(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:126449298-126449299(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:126449305-126449306(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:126449311-126449312(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:126449334-126449335(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:126449415-126449416(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:126449454-126449455(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:126449471-126449472(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:126449507-126449508(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr8:126449569-126449570(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085
chr8:126449643-126449644(+) m6A 3'UTR       25456834//24981863//22608085
chr8:126449650-126449651(+) m6A 3'UTR       25456834//24981863//22608085
chr8:126449702-126449703(+) m6A 3'UTR       24981863//26404942//22608085
chr8:126449849-126449850(+) m6A 3'UTR       24981863//26404942
chr8:126449856-126449857(+) m6A 3'UTR       24981863//26404942
chr8:126449882-126449883(+) m6A 3'UTR       24981863//26404942
chr8:126450005-126450006(+) m6A 3'UTR       24284625//24981863
chr8:126450062-126450063(+) m6A 3'UTR       24981863
chr8:126450096-126450097(+) m6A 3'UTR       24981863
chr8:126450365-126450366(+) m6A 3'UTR       24284625//24981863//26404942//27773535
chr8:126450418-126450419(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr8:126450436-126450437(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr8:126450510-126450511(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr8:126450549-126450550(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr8:126450587-126450588(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr8:126450630-126450631(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TRIB1
Exosome Blood     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART6-3p
Interactor2: TRIB1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase

References:


PMID 22100165 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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