Basic Information:

  VIRBase ID:  

VHID00316829

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART6-3p:  MIMAT0003415          UBA1:  NM_003334     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART6-3p	UBA1
miRBase Accession/Entrez ID	MIMAT0003415	7317
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	A1S9//A1S9T//A1ST//AMCX1//CFAP124//GXP1//POC20//SMAX2//UBA1A//UBE1//UBE1X//VEXAS

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBA1	chrX:47052179(+) A-I      intronic chrX:47067692(+) A-I      intronic chrX:47067670(+) A-I      intronic chrX:47063356(+) A-I      intronic chrX:47063326(+) A-I      intronic chrX:47067772(+) A-I      intronic chrX:47063277(+) A-I      intronic chrX:47067784(+) A-I      intronic chrX:47067837(+) A-I      intronic chrX:47063228(+) A-I      intronic chrX:47063399(+) A-I      intronic chrX:47067643(+) A-I      intronic chrX:47067845(+) A-I      intronic chrX:47063248(+) A-I      intronic chrX:47067575(+) A-I      intronic chrX:47063421(+) A-I      intronic chrX:47067585(+) A-I      intronic chrX:47067825(+) A-I      intronic chrX:47063321(+) A-I      intronic chrX:47063409(+) A-I      intronic chrX:47067815(+) A-I      intronic chrX:47063293(+) A-I      intronic chrX:47063225(+) A-I      intronic chrX:47067798(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBA1	chrX:47068232(+) A-I intron -    15342557   //15258596 chrX:47068234(+) A-I intron -    15342557   //15258596 chrX:47068235(+) A-I intron -    15342557   //15258596 chrX:47068287(+) A-I intron -    15342557   //15258596 chrX:47068298(+) A-I intron -    15342557   //15258596 chrX:47068307(+) A-I intron -    15342557   //15258596 chrX:47068577(+) A-I intron -    15342557   //15258596 chrX:47068579(+) A-I intron -    15342557   //15258596 chrX:47068692(+) A-I intron -    15342557   //15258596 chrX:47068694(+) A-I intron -    15342557   //15258596 chrX:47068714(+) A-I intron -    15342557   //15258596 chrX:47068753(+) A-I intron -    15342557   //15258596 chrX:47068762(+) A-I intron -    15342557   //15258596 chrX:47068805(+) A-I intron -    15342557   //15258596 chrX:47067783(+) A-I intron -    21960545 chrX:47068298(+) A-G intron -    21725310   //22484847 chrX:47068579(+) A-G intron -    21725310   //22484847 chrX:47068256(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBA1	chrX:47050824-47050825(+) m6A 5'UTR//intron       24284625//24981863//22575960 chrX:47050832-47050833(+) m6A 5'UTR//intron       24284625//22575960 chrX:47050837-47050838(+) m6A 5'UTR//intron       24284625//22575960 chrX:47050898-47050899(+) m6A 5'UTR//intron       24284625 chrX:47053266-47053267(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chrX:47053413-47053414(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960 chrX:47056626-47056627(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960 chrX:47058474-47058475(+) m6A CDS       22575960 chrX:47058699-47058700(+) m6A CDS       22575960 chrX:47061802-47061803(+) m6A CDS       22575960 chrX:47062050-47062051(+) m6A CDS       22575960 chrX:47062411-47062412(+) m6A CDS//exon       22575960 chrX:47062432-47062433(+) m6A CDS//exon       22575960 chrX:47062539-47062540(+) m6A CDS//exon       22575960 chrX:47062575-47062576(+) m6A CDS//exon       22575960 chrX:47062976-47062977(+) m6A CDS//exon       26404942//22575960 chrX:47063030-47063031(+) m6A CDS//exon       26404942//22575960 chrX:47063036-47063037(+) m6A CDS//exon       26404942//22575960 chrX:47064416-47064417(+) m6A intron       27773535 chrX:47064425-47064426(+) m6A intron       27773535 chrX:47064430-47064431(+) m6A intron       27773535 chrX:47064509-47064510(+) m6A intron       27773535 chrX:47064527-47064528(+) m6A intron       27773535 chrX:47064779-47064780(+) m6A intron       - chrX:47065419-47065420(+) m6A CDS//intron       22575960 chrX:47065470-47065471(+) m6A CDS//intron       22575960 chrX:47065497-47065498(+) m6A CDS//exon       22575960 chrX:47065658-47065659(+) m6A CDS//exon       22575960 chrX:47065772-47065773(+) m6A CDS//exon       26404942//27773535//22575960 chrX:47065811-47065812(+) m6A CDS//exon       26404942//27773535 chrX:47069328-47069329(+) m6A CDS       22575960 chrX:47069348-47069349(+) m6A CDS       22575960 chrX:47069426-47069427(+) m6A CDS       22575960 chrX:47069481-47069482(+) m6A CDS       22575960 chrX:47070447-47070448(+) m6A CDS       22575960 chrX:47070482-47070483(+) m6A CDS       22575960 chrX:47070507-47070508(+) m6A CDS       22575960 chrX:47071867-47071868(+) m6A CDS       22575960 chrX:47072230-47072231(+) m6A CDS       22575960 chrX:47072251-47072252(+) m6A CDS       22575960 chrX:47072555-47072556(+) m6A CDS       22575960 chrX:47074460-47074461(+) m6A 3'UTR       24284625//24981863//27773535 chrX:47074494-47074495(+) m6A 3'UTR       24284625//24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	UBA1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART6-3p
Interactor2: UBA1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.