Basic Information:

  VIRBase ID:  

VHID00316250

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART6-3p:  MIMAT0003415          GNAI2:  NM_001282620     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART6-3p	GNAI2
miRBase Accession/Entrez ID	MIMAT0003415	2771
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	GIP//GNAI2B//H_LUCA15.1//H_LUCA16.1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GNAI2	chr3:50287150(+) A-I      intronic chr3:50285502(+) A-I      intronic chr3:50285650(+) A-I      intronic chr3:50285573(+) A-I      intronic chr3:50278280(+) A-I      intronic chr3:50285618(+) A-I      intronic chr3:50285569(+) A-I      intronic chr3:50285391(+) A-I      intronic chr3:50278368(+) A-I      intronic chr3:50282570(+) A-I      intronic chr3:50282479(+) A-I      intronic chr3:50288407(+) A-I      intronic chr3:50278290(+) A-I      intronic chr3:50281735(+) A-I      intronic chr3:50285546(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GNAI2	chr3:50281650(+) G-A intron -    22484847 chr3:50282479(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GNAI2	chr3:50263999-50264000(+) m6A 5'UTR       25456834 chr3:50267654-50267655(+) m6A exon//intron       - chr3:50267815-50267816(+) m6A exon//intron       - chr3:50267863-50267864(+) m6A exon//intron       - chr3:50267900-50267901(+) m6A exon//intron       - chr3:50267913-50267914(+) m6A exon//intron       - chr3:50267933-50267934(+) m6A exon//intron       - chr3:50268050-50268051(+) m6A exon//intron       - chr3:50268066-50268067(+) m6A exon//intron       - chr3:50268097-50268098(+) m6A exon//intron       - chr3:50268119-50268120(+) m6A exon//intron       - chr3:50268301-50268302(+) m6A 5'UTR//exon//intron       - chr3:50268315-50268316(+) m6A 5'UTR//exon//intron       - chr3:50268341-50268342(+) m6A 5'UTR//exon//intron       - chr3:50268400-50268401(+) m6A 5'UTR//exon//intron       - chr3:50273646-50273647(+) m6A 5'UTR//intron       24209618//25456834//24981863 chr3:50273792-50273793(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//22575960 chr3:50273831-50273832(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//22575960 chr3:50275677-50275678(+) m6A 5'UTR//intron       24284625//24209618 chr3:50289605-50289606(+) m6A exon//intron       24284625//24209618//25456834//24981863 chr3:50289780-50289781(+) m6A exon//intron       24209618//24981863 chr3:50289798-50289799(+) m6A exon//intron       24209618//24981863 chr3:50293690-50293691(+) m6A 3'UTR//CDS//exon       22575960 chr3:50293702-50293703(+) m6A 3'UTR//CDS//exon       22575960 chr3:50293720-50293721(+) m6A 3'UTR//CDS//exon       22575960 chr3:50293739-50293740(+) m6A 3'UTR//CDS//exon       22575960 chr3:50294429-50294430(+) m6A 3'UTR//CDS//exon       - chr3:50294462-50294463(+) m6A 3'UTR//CDS//exon       - chr3:50294982-50294983(+) m6A 3'UTR//CDS//exon       - chr3:50295000-50295001(+) m6A 3'UTR//CDS//exon       - chr3:50295008-50295009(+) Gm 3'UTR//CDS//exon       - chr3:50295093-50295094(+) m6A 3'UTR//CDS//exon       24284625 chr3:50295105-50295106(+) m6A 3'UTR//CDS//exon       24284625 chr3:50295183-50295184(+) m6A exon//intron       24284625 chr3:50295237-50295238(+) m6A exon//intron       24284625//24981863 chr3:50295271-50295272(+) m6A exon//intron       24981863 chr3:50295371-50295372(+) m6A exon//intron       24209618//24981863 chr3:50295397-50295398(+) m6A exon//intron       24284625//24209618//24981863 chr3:50295402-50295403(+) m6A exon//intron       24284625//24209618//24981863 chr3:50296131-50296132(+) m6A 3'UTR//exon       24284625 chr3:50296277-50296278(+) m6A 3'UTR//exon       24284625//24981863//27773535//27371828//22608085 chr3:50296341-50296342(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr3:50296357-50296358(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr3:50296372-50296373(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr3:50296382-50296383(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr3:50296546-50296547(+) m6A 3'UTR//exon       24284625//22575960 chr3:50296638-50296639(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GNAI2	Chromatin K562 cells     - Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART6-3p
Interactor2: GNAI2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.