Basic Information:

  VIRBase ID:  

VHID00315708

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART6-5p:  MIMAT0003414          FAM174A:  NM_198507     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART6-5p	FAM174A
miRBase Accession/Entrez ID	MIMAT0003414	345757
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HGS_RE408//NS5ATP6//TMEM157//UNQ1912

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM174A	chr5:99879057(+) A-I      intronic chr5:99879811(+) A-I      intronic chr5:99921283(+) A-I      intronic chr5:99921257(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM174A	chr5:99879032(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM174A	chr5:99871059-99871060(+) m6A 5'UTR       24981863 chr5:99871308-99871309(+) m6A CDS//exon       24284625 chr5:99871380-99871381(+) m6A CDS//exon       24284625 chr5:99871387-99871388(+) m6A CDS//exon       24284625 chr5:99897766-99897767(+) m1A CDS//exon//intron       26863196 chr5:99897771-99897772(+) m6A CDS//exon//intron       24209618 chr5:99897779-99897780(+) m6A CDS//exon//intron       24209618//24981863 chr5:99897801-99897802(+) m6A CDS//exon//intron       24209618//24981863 chr5:99897838-99897839(+) m6A CDS//exon//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FAM174A	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART6-5p
Interactor2: FAM174A

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.