Detail Information

Basic Information:


  VIRBase ID:  

VHID00314285

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART6-5p:           TMEM97:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART6-5p TMEM97
miRBase
Accession/Entrez ID		 MIMAT0003414 27346
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - MAC30//sigma2R

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM97
chr17:26654244(+) A-I      3'UTR
chr17:26654249(+) A-I      3'UTR
chr17:26650903(+) A-I      intronic
chr17:26650566(+) A-I      intronic
chr17:26650806(+) A-I      intronic
chr17:26654225(+) A-I      3'UTR
chr17:26654121(+) A-I      3'UTR
chr17:26654072(+) A-I      3'UTR
chr17:26650558(+) A-I      intronic
chr17:26654271(+) A-I      3'UTR
chr17:26654232(+) A-I      3'UTR
chr17:26654117(+) A-I      3'UTR
chr17:26654113(+) A-I      3'UTR
chr17:26654008(+) A-I      3'UTR
chr17:26650987(+) A-I      intronic
chr17:26650705(+) A-I      intronic
chr17:26650965(+) A-I      intronic
chr17:26654127(+) A-I      3'UTR
chr17:26654137(+) A-I      3'UTR
chr17:26654231(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMEM97
chr17:26654232(+) A-I intron -    21960545
chr17:26654113(+) A-G intron -    22484847
chr17:26654121(+) A-G intron -    22484847
chr17:26654137(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM97
chr17:26652535-26652536(+) m6A 5'UTR//CDS//intron       24284625
chr17:26652568-26652569(+) m6A 5'UTR//CDS//intron       24284625
chr17:26652829-26652830(+) m6A 3'UTR//intron       24284625//24209618//22608085
chr17:26653579-26653580(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653680-26653681(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653686-26653687(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653693-26653694(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653824-26653825(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653887-26653888(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653899-26653900(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653924-26653925(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653963-26653964(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr17:26653973-26653974(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654009-26654010(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654123-26654124(+) m6A 3'UTR       24209618//24981863
chr17:26654183-26654184(+) m6A 3'UTR       24209618
chr17:26654280-26654281(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654299-26654300(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr17:26654328-26654329(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085
chr17:26654436-26654437(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654441-26654442(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654448-26654449(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654459-26654460(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654520-26654521(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26655132-26655133(+) m6A 3'UTR       27773535
chr17:26655361-26655362(+) m6A 3'UTR       27773535
chr17:26655428-26655429(+) m6A 3'UTR       27773535
chr17:26655508-26655509(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr17:26655522-26655523(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TMEM97
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART6-5p
Interactor2: TMEM97

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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