Basic Information:

  VIRBase ID:  

VHID00311565

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART5-5p:  MIMAT0003413          PARD6B:  NM_032521     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART5-5p	PARD6B
miRBase Accession/Entrez ID	MIMAT0003413	84612
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAR6B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PARD6B	chr20:49357637(+) A-I      intronic chr20:49353437(+) A-I      intronic chr20:49353395(+) A-I      intronic chr20:49351511(+) A-I      intronic chr20:49351320(+) A-I      intronic chr20:49355823(+) A-I      intronic chr20:49351024(+) A-I      intronic chr20:49355822(+) A-I      intronic chr20:49351022(+) A-I      intronic chr20:49351425(+) A-I      intronic chr20:49372363(+) A-I      intronic chr20:49365181(+) A-I      intronic chr20:49364638(+) A-I      intronic chr20:49364614(+) A-I      intronic chr20:49362305(+) A-I      intronic chr20:49360305(+) A-I      intronic chr20:49360170(+) A-I      intronic chr20:49358717(+) A-I      intronic chr20:49358660(+) A-I      intronic chr20:49358641(+) A-I      intronic chr20:49358629(+) A-I      intronic chr20:49355864(+) A-I      intronic chr20:49351454(+) A-I      intronic chr20:49355837(+) A-I      intronic chr20:49372439(+) A-I      intronic chr20:49372444(+) A-I      intronic chr20:49360315(+) A-I      intronic chr20:49355831(+) A-I      intronic chr20:49355819(+) A-I      intronic chr20:49355807(+) A-I      intronic chr20:49353418(+) A-I      intronic chr20:49353364(+) A-I      intronic chr20:49353312(+) A-I      intronic chr20:49353299(+) A-I      intronic chr20:49353291(+) A-I      intronic chr20:49351632(+) A-I      intronic chr20:49351608(+) A-I      intronic chr20:49351607(+) A-I      intronic chr20:49372434(+) A-I      intronic chr20:49360214(+) A-I      intronic chr20:49351293(+) A-I      intronic chr20:49353496(+) A-I      intronic chr20:49360217(+) A-I      intronic chr20:49351556(+) A-I      intronic chr20:49370830(+) A-I      intronic chr20:49350945(+) A-I      intronic chr20:49351567(+) A-I      intronic chr20:49353487(+) A-I      intronic chr20:49360237(+) A-I      intronic chr20:49357772(+) A-I      intronic chr20:49350937(+) A-I      intronic chr20:49365176(+) A-I      intronic chr20:49365786(+) A-I      intronic chr20:49349951(+) A-I      intronic chr20:49368157(+) A-I      3'UTR chr20:49364766(+) A-I      intronic chr20:49365603(+) A-I      intronic chr20:49360781(+) A-I      intronic chr20:49362318(+) A-I      intronic chr20:49365356(+) A-I      intronic chr20:49353308(+) A-I      intronic chr20:49365702(+) A-I      intronic chr20:49365291(+) A-I      intronic chr20:49365349(+) A-I      intronic chr20:49351501(+) A-I      intronic chr20:49362176(+) A-I      intronic chr20:49349776(+) A-I      intronic chr20:49361809(+) A-I      intronic chr20:49360171(+) A-I      intronic chr20:49360791(+) A-I      intronic chr20:49365721(+) A-I      intronic chr20:49355374(+) A-I      intronic chr20:49358764(+) A-I      intronic chr20:49351566(+) A-I      intronic chr20:49372457(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PARD6B	chr20:49349747(+) A-I intron -    21960545 chr20:49351017(+) A-I intron -    21960545 chr20:49351022(+) A-I intron -    21960545 chr20:49351241(+) A-I intron -    21960545 chr20:49351293(+) A-I intron -    21960545 chr20:49351567(+) A-I intron -    21960545 chr20:49355420(+) A-I intron -    21960545 chr20:49362282(+) A-I intron -    21960545 chr20:49362305(+) A-I intron -    21960545 chr20:49362306(+) A-I intron -    21960545 chr20:49365291(+) A-I intron -    21960545 chr20:49365349(+) A-G intron -    22484847 chr20:49365689(+) G-C intron -    22484847 chr20:49365702(+) A-G intron -    22484847 chr20:49365721(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PARD6B	chr20:49348327-49348328(+) m6A CDS       - chr20:49354434-49354435(+) m6A CDS       22608085 chr20:49354517-49354518(+) m6A CDS       24981863//22608085 chr20:49354529-49354530(+) m6A CDS       24981863//22608085 chr20:49366204-49366205(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366225-49366226(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366318-49366319(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366325-49366326(+) m6A CDS//intron       24284625//24981863//22608085 chr20:49366406-49366407(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr20:49366526-49366527(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366603-49366604(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366646-49366647(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366654-49366655(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366678-49366679(+) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085 chr20:49366686-49366687(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366748-49366749(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366774-49366775(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366804-49366805(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366895-49366896(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366954-49366955(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366968-49366969(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49366988-49366989(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49367007-49367008(+) m6A CDS//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr20:49367026-49367027(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr20:49367066-49367067(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr20:49367192-49367193(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr20:49367226-49367227(+) m6A 3'UTR//intron       24981863//22608085 chr20:49367307-49367308(+) m6A 3'UTR//intron       22608085 chr20:49367320-49367321(+) m6A 3'UTR//intron       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PARD6B	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART5-5p
Interactor2: PARD6B

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.