Basic Information:

  VIRBase ID:  

VHID00309828

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART5-5p:  MIMAT0003413          MAGED2:  NM_014599     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART5-5p	MAGED2
miRBase Accession/Entrez ID	MIMAT0003413	10916
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	11B6//BARTS5//BCG-1//BCG1//HCA10//MAGE-D2

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MAGED2	chrX:54842324(+) T-C intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MAGED2	chrX:54834180-54834181(+) m6A 5'UTR       24284625//25456834//24981863 chrX:54834192-54834193(+) m6A 5'UTR//exon       24284625//25456834//24981863 chrX:54834218-54834219(+) m6A 5'UTR//exon       24284625//25456834//24981863 chrX:54834230-54834231(+) m6A 5'UTR//exon       24284625//25456834//24981863 chrX:54834775-54834776(+) m6A 5'UTR//intron       - chrX:54835574-54835575(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863 chrX:54835645-54835646(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863 chrX:54835762-54835763(+) m6A 5'UTR//exon       24981863 chrX:54836173-54836174(+) m6A CDS//exon//intron       24981863 chrX:54836193-54836194(+) m6A CDS//exon//intron       24981863 chrX:54836232-54836233(+) m6A CDS//exon//intron       - chrX:54837409-54837410(+) m6A CDS//exon//intron       24284625//25456834//24981863 chrX:54841865-54841866(+) m6A CDS       25456834//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MAGED2	Chromatin HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART5-5p
Interactor2: MAGED2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.