Basic Information:

  VIRBase ID:  

VHID00309745

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART5-5p:  MIMAT0003413          CARM1:  NM_001370088     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART5-5p	CARM1
miRBase Accession/Entrez ID	MIMAT0003413	10498
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRMT4

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CARM1	chr19:11028988(+) A-I      intronic chr19:11028940(+) A-I      intronic chr19:11029002(+) A-I      intronic chr19:11029043(+) A-I      intronic chr19:11021750(+) A-I      intronic chr19:11021732(+) A-I      intronic chr19:11021767(+) A-I      intronic chr19:11021859(+) A-I      intronic chr19:11027975(+) A-I      intronic chr19:11028918(+) A-I      intronic chr19:11029037(+) A-I      intronic chr19:11028573(+) A-I      intronic chr19:11028563(+) A-I      intronic chr19:11028562(+) A-I      intronic chr19:11024195(+) A-I      intronic chr19:11024146(+) A-I      intronic chr19:11023860(+) A-I      intronic chr19:11021636(+) A-I      intronic chr19:11021618(+) A-I      intronic chr19:11021306(+) A-I      intronic chr19:11021305(+) A-I      intronic chr19:11021303(+) A-I      intronic chr19:11021301(+) A-I      intronic chr19:11021036(+) A-I      intronic chr19:11021030(+) A-I      intronic chr19:11020992(+) A-I      intronic chr19:11020988(+) A-I      intronic chr19:11020898(+) A-I      intronic chr19:11020897(+) A-I      intronic chr19:11020879(+) A-I      intronic chr19:11020319(+) A-I      intronic chr19:11020229(+) A-I      intronic chr19:10986347(+) A-I      intronic chr19:10985621(+) A-I      intronic chr19:10986817(+) A-I      intronic chr19:10986802(+) A-I      intronic chr19:10994615(+) A-I      intronic chr19:10994644(+) A-I      intronic chr19:10995480(+) A-I      intronic chr19:10995481(+) A-I      intronic chr19:10995510(+) A-I      intronic chr19:10995517(+) A-I      intronic chr19:10995591(+) A-I      intronic chr19:10996802(+) A-I      intronic chr19:10996807(+) A-I      intronic chr19:10996832(+) A-I      intronic chr19:10996833(+) A-I      intronic chr19:10997072(+) A-I      intronic chr19:10997119(+) A-I      intronic chr19:10986307(+) A-I      intronic chr19:10986218(+) A-I      intronic chr19:10986181(+) A-I      intronic chr19:10986157(+) A-I      intronic chr19:10986150(+) A-I      intronic chr19:10986120(+) A-I      intronic chr19:10985687(+) A-I      intronic chr19:10997248(+) A-I      intronic chr19:10985545(+) A-I      intronic chr19:10985342(+) A-I      intronic chr19:10997249(+) A-I      intronic chr19:10998380(+) A-I      intronic chr19:11001620(+) A-I      intronic chr19:11005995(+) A-I      intronic chr19:11006016(+) A-I      intronic chr19:11011489(+) A-I      intronic chr19:11011496(+) A-I      intronic chr19:11011499(+) A-I      intronic chr19:11011541(+) A-I      intronic chr19:11011558(+) A-I      intronic chr19:11011621(+) A-I      intronic chr19:11011732(+) A-I      intronic chr19:11011737(+) A-I      intronic chr19:11011761(+) A-I      intronic chr19:11012341(+) A-I      intronic chr19:11012403(+) A-I      intronic chr19:11012416(+) A-I      intronic chr19:11012437(+) A-I      intronic chr19:11012471(+) A-I      intronic chr19:11012613(+) A-I      intronic chr19:11012664(+) A-I      intronic chr19:11012769(+) A-I      intronic chr19:11012770(+) A-I      intronic chr19:10984050(+) A-I      intronic chr19:10984092(+) A-I      intronic chr19:10984111(+) A-I      intronic chr19:10984186(+) A-I      intronic chr19:10984445(+) A-I      intronic chr19:10984452(+) A-I      intronic chr19:10984500(+) A-I      intronic chr19:10984502(+) A-I      intronic chr19:10984514(+) A-I      intronic chr19:10984842(+) A-I      intronic chr19:10985079(+) A-I      intronic chr19:10985087(+) A-I      intronic chr19:10985181(+) A-I      intronic chr19:10985198(+) A-I      intronic chr19:10985205(+) A-I      intronic chr19:10985338(+) A-I      intronic chr19:11013402(+) A-I      intronic chr19:11013495(+) A-I      intronic chr19:11013507(+) A-I      intronic chr19:11013508(+) A-I      intronic chr19:11019996(+) A-I      intronic chr19:11011477(+) A-I      intronic chr19:10994609(+) A-I      intronic chr19:10994532(+) A-I      intronic chr19:10994529(+) A-I      intronic chr19:10994523(+) A-I      intronic chr19:10994508(+) A-I      intronic chr19:10994493(+) A-I      intronic chr19:10994484(+) A-I      intronic chr19:10994465(+) A-I      intronic chr19:10994438(+) A-I      intronic chr19:10994419(+) A-I      intronic chr19:10994409(+) A-I      intronic chr19:10994382(+) A-I      intronic chr19:10994330(+) A-I      intronic chr19:10993427(+) A-I      intronic chr19:10993418(+) A-I      intronic chr19:10993271(+) A-I      intronic chr19:10993269(+) A-I      intronic chr19:10991794(+) A-I      intronic chr19:10991767(+) A-I      intronic chr19:10991696(+) A-I      intronic chr19:10991693(+) A-I      intronic chr19:10991568(+) A-I      intronic chr19:10991213(+) A-I      intronic chr19:10991115(+) A-I      intronic chr19:10991061(+) A-I      intronic chr19:10990583(+) A-I      intronic chr19:10990525(+) A-I      intronic chr19:10990520(+) A-I      intronic chr19:10990415(+) A-I      intronic chr19:10990375(+) A-I      intronic chr19:10988336(+) A-I      intronic chr19:10986970(+) A-I      intronic chr19:10990390(+) A-I      intronic chr19:11011825(+) A-I      intronic chr19:11028950(+) A-I      intronic chr19:11011566(+) A-I      intronic chr19:11023898(+) A-I      intronic chr19:11010866(+) A-I      intronic chr19:11021502(+) A-I      intronic chr19:11024026(+) A-I      intronic chr19:11028552(+) A-I      intronic chr19:11021165(+) A-I      intronic chr19:10984177(+) A-I      intronic chr19:10985290(+) A-I      intronic chr19:10984074(+) A-I      intronic chr19:11013167(+) A-I      intronic chr19:10997360(+) A-I      intronic chr19:10984060(+) A-I      intronic chr19:11028494(+) A-I      intronic chr19:11027885(+) A-I      intronic chr19:10996619(+) A-I      intronic chr19:10990423(+) A-I      intronic chr19:11027976(+) A-I      intronic chr19:11021425(+) A-I      intronic chr19:10994859(+) A-I      intronic chr19:10994809(+) A-I      intronic chr19:11028650(+) A-I      intronic chr19:10994972(+) A-I      intronic chr19:10988178(+) A-I      intronic chr19:10993311(+) A-I      intronic chr19:10997342(+) A-I      intronic chr19:11020875(+) A-I      intronic chr19:10985167(+) A-I      intronic chr19:10995131(+) A-I      intronic chr19:10993249(+) A-I      intronic chr19:11023881(+) A-I      intronic chr19:11012363(+) A-I      intronic chr19:11021359(+) A-I      intronic chr19:11013050(+) A-I      intronic chr19:10988155(+) A-I      intronic chr19:11021514(+) A-I      intronic chr19:10991585(+) A-I      intronic chr19:11005955(+) A-I      intronic chr19:10994534(+) A-I      intronic chr19:11013542(+) A-I      intronic chr19:11000742(+) A-I      intronic chr19:11029179(+) A-I      intronic chr19:10995547(+) A-I      intronic chr19:11027929(+) A-I      intronic chr19:11021145(+) A-I      intronic chr19:10991633(+) A-I      intronic chr19:11028513(+) A-I      intronic chr19:11029695(+) A-I      intronic chr19:11029038(+) A-I      intronic chr19:10994763(+) A-I      intronic chr19:10991091(+) A-I      intronic chr19:10995082(+) A-I      intronic chr19:10985277(+) A-I      intronic chr19:11029041(+) A-I      intronic chr19:11012419(+) A-I      intronic chr19:11001273(+) A-I      intronic chr19:10984171(+) A-I      intronic chr19:11013458(+) A-I      intronic chr19:10993452(+) A-I      intronic chr19:11020946(+) A-I      intronic chr19:11027908(+) A-I      intronic chr19:11027668(+) A-I      intronic chr19:11028568(+) A-I      intronic chr19:10984420(+) A-I      intronic chr19:10993423(+) A-I      intronic chr19:11013192(+) A-I      intronic chr19:10991793(+) A-I      intronic chr19:10985539(+) A-I      intronic chr19:11005981(+) A-I      intronic chr19:11028455(+) A-I      intronic chr19:11029104(+) A-I      intronic chr19:10997009(+) A-I      intronic chr19:11010619(+) A-I      intronic chr19:10985537(+) A-I      intronic chr19:11029027(+) A-I      intronic chr19:10994333(+) A-I      intronic chr19:11028143(+) A-I      intronic chr19:11024155(+) A-I      intronic chr19:10985288(+) A-I      intronic chr19:11012867(+) A-I      intronic chr19:10984577(+) A-I      intronic chr19:10990416(+) A-I      intronic chr19:10993383(+) A-I      intronic chr19:10997448(+) A-I      intronic chr19:11027681(+) A-I      intronic chr19:11029072(+) A-I      intronic chr19:11021667(+) A-I      intronic chr19:11012418(+) A-I      intronic chr19:11028920(+) A-I      intronic chr19:11023979(+) A-I      intronic chr19:11011880(+) A-I      intronic chr19:11010538(+) A-I      intronic chr19:11028571(+) A-I      intronic chr19:11011758(+) A-I      intronic chr19:11023867(+) A-I      intronic chr19:11020195(+) A-I      intronic chr19:11001141(+) A-I      intronic chr19:11021836(+) A-I      intronic chr19:11027687(+) A-I      intronic chr19:11012718(+) A-I      intronic chr19:10985168(+) A-I      intronic chr19:11011722(+) A-I      intronic chr19:11029019(+) A-I      intronic chr19:10985620(+) A-I      intronic chr19:10997370(+) A-I      intronic chr19:11000821(+) A-I      intronic chr19:10985483(+) A-I      intronic chr19:11010841(+) A-I      intronic chr19:11012496(+) A-I      intronic chr19:11023845(+) A-I      intronic chr19:11029741(+) A-I      intronic chr19:11021170(+) A-I      intronic chr19:11028468(+) A-I      intronic chr19:10985555(+) A-I      intronic chr19:11012866(+) A-I      intronic chr19:11012481(+) A-I      intronic chr19:11008922(+) A-I      intronic chr19:10994329(+) A-I      intronic chr19:10985289(+) A-I      intronic chr19:10993317(+) A-I      intronic chr19:11029133(+) A-I      intronic chr19:11010751(+) A-I      intronic chr19:10993446(+) A-I      intronic chr19:11021590(+) A-I      intronic chr19:10994316(+) A-I      intronic chr19:10994804(+) A-I      intronic chr19:11012510(+) A-I      intronic chr19:10994866(+) A-I      intronic chr19:10995381(+) A-I      intronic chr19:11012811(+) A-I      intronic chr19:10994252(+) A-I      intronic chr19:10985547(+) A-I      intronic chr19:11021371(+) A-I      intronic chr19:10985227(+) A-I      intronic chr19:10997045(+) A-I      intronic chr19:11023861(+) A-I      intronic chr19:11011839(+) A-I      intronic chr19:11023957(+) A-I      intronic chr19:10991691(+) A-I      intronic chr19:11029028(+) A-I      intronic chr19:10984083(+) A-I      intronic chr19:10984110(+) A-I      intronic chr19:11027987(+) A-I      intronic chr19:10984093(+) A-I      intronic chr19:11021487(+) A-I      intronic chr19:11021501(+) A-I      intronic chr19:10984094(+) A-I      intronic chr19:10994897(+) A-I      intronic chr19:10988701(+) A-I      intronic chr19:11012799(+) A-I      intronic chr19:10990500(+) A-I      intronic chr19:11021787(+) A-I      intronic chr19:11028463(+) A-I      intronic chr19:10991277(+) A-I      intronic chr19:10994769(+) A-I      intronic chr19:10996999(+) A-I      intronic chr19:10985538(+) A-I      intronic chr19:11029031(+) A-I      intronic chr19:10993481(+) A-I      intronic chr19:11024093(+) A-I      intronic chr19:10998341(+) A-I      intronic chr19:10985629(+) A-I      intronic chr19:11012854(+) A-I      intronic chr19:10994334(+) A-I      intronic chr19:10985540(+) A-I      intronic chr19:11010577(+) A-I      intronic chr19:10991721(+) A-I      intronic chr19:11003853(+) A-I      intronic chr19:11012579(+) A-I      intronic chr19:10985348(+) A-I      intronic chr19:11021598(+) A-I      intronic chr19:11010581(+) A-I      intronic chr19:11028649(+) A-I      intronic chr19:11012557(+) A-I      intronic chr19:10993298(+) A-I      intronic chr19:11012665(+) A-I      intronic chr19:11028548(+) A-I      intronic chr19:10991781(+) A-I      intronic chr19:10985179(+) A-I      intronic chr19:11013044(+) A-I      intronic chr19:10984396(+) A-I      intronic chr19:11010857(+) A-I      intronic chr19:11021841(+) A-I      intronic chr19:11012431(+) A-I      intronic chr19:11029082(+) A-I      intronic chr19:10985639(+) A-I      intronic chr19:11027930(+) A-I      intronic chr19:10985129(+) A-I      intronic chr19:11020302(+) A-I      intronic chr19:10985536(+) A-I      intronic chr19:10985256(+) A-I      intronic chr19:11001257(+) A-I      intronic chr19:11018214(+) A-I      intronic chr19:11012574(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CARM1	chr19:11015664(+) A-I exon CDS    19478186 chr19:10984083(+) A-G intron -    22484847 chr19:10984084(+) A-G intron -    22484847 chr19:10984093(+) A-G intron -    22484847 chr19:10984094(+) A-G intron -    22484847 chr19:10985688(+) A-G intron -    22484847 chr19:11020415(+) A-C intron -    22484847 chr19:11027663(+) A-G intron -    22484847 chr19:11027908(+) A-G intron -    22484847 chr19:11027929(+) A-G intron -    22484847 chr19:11027976(+) A-G intron -    22484847 chr19:11028424(+) T-C intron -    22484847 chr19:11028920(+) A-G intron -    22484847 chr19:11029104(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CARM1	chr19:10982571-10982572(+) m6A CDS       24209618//22575960 chr19:11015667-11015668(+) m6A CDS//intron       22575960 chr19:11029692-11029693(+) m6A exon//intron       27773535 chr19:11029979-11029980(+) m6A exon//intron       27773535 chr19:11030623-11030624(+) Y 3'UTR//CDS//exon       26075521 chr19:11031223-11031224(+) m6A 3'UTR//CDS//exon//intron       22575960 chr19:11031369-11031370(+) m6A 3'UTR//CDS//exon       22575960 chr19:11031374-11031375(+) m6A 3'UTR//CDS//exon       22575960 chr19:11031411-11031412(+) m6A 3'UTR//CDS//exon       22575960 chr19:11032448-11032449(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:11032465-11032466(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:11032531-11032532(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:11032562-11032563(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:11032568-11032569(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:11032726-11032727(+) m6A 3'UTR       24284625 chr19:11032901-11032902(+) m6A 3'UTR       - chr19:11032919-11032920(+) m6A 3'UTR       - chr19:11032971-11032972(+) m6A 3'UTR       - chr19:11033226-11033227(+) m6A 3'UTR       - chr19:11033232-11033233(+) m6A 3'UTR       - chr19:11033372-11033373(+) m6A 3'UTR       - chr19:11033383-11033384(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CARM1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART5-5p
Interactor2: CARM1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BCBL-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.