Basic Information:

  VIRBase ID:  

VHID00307850

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART4-5p:  MIMAT0003412          ZBTB34:  NM_001099270     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART4-5p	ZBTB34
miRBase Accession/Entrez ID	MIMAT0003412	403341
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZNF918

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZBTB34	chr9:129640128(+) A-I      intronic chr9:129641225(+) A-I      intronic chr9:129641238(+) A-I      intronic chr9:129633742(+) A-I      intronic chr9:129633741(+) A-I      intronic chr9:129636045(+) A-I      intronic chr9:129641223(+) A-I      intronic chr9:129640704(+) A-I      intronic chr9:129640694(+) A-I      intronic chr9:129640690(+) A-I      intronic chr9:129633746(+) A-I      intronic chr9:129640494(+) A-I      intronic chr9:129634365(+) A-I      intronic chr9:129640539(+) A-I      intronic chr9:129634413(+) A-I      intronic chr9:129633745(+) A-I      intronic chr9:129640155(+) A-I      intronic chr9:129640198(+) A-I      intronic chr9:129646380(+) A-I      3'UTR chr9:129633113(+) A-I      intronic chr9:129634140(+) A-I      intronic chr9:129640524(+) A-I      intronic chr9:129640176(+) A-I      intronic chr9:129641128(+) A-I      intronic chr9:129640163(+) A-I      intronic chr9:129641265(+) A-I      intronic chr9:129641103(+) A-I      intronic chr9:129641097(+) A-I      intronic chr9:129641183(+) A-I      intronic chr9:129640642(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZBTB34	chr9:129623014-129623015(+) m6A 5'UTR       24284625 chr9:129641651-129641652(+) m6A 5'UTR//intron       24284625//22608085 chr9:129641694-129641695(+) m6A CDS       24284625//24981863//22575960//22608085 chr9:129641761-129641762(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr9:129641779-129641780(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr9:129641865-129641866(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642147-129642148(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642291-129642292(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642342-129642343(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642357-129642358(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642484-129642485(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr9:129642732-129642733(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642927-129642928(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642967-129642968(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643038-129643039(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643088-129643089(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643105-129643106(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643111-129643112(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643215-129643216(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643330-129643331(+) m6A 3'UTR       24284625//24981863//22608085 chr9:129643411-129643412(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:129643442-129643443(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:129644892-129644893(+) m6A 3'UTR       - chr9:129644935-129644936(+) m6A 3'UTR       - chr9:129644970-129644971(+) m6A 3'UTR       - chr9:129646203-129646204(+) m6A 3'UTR       24284625//24981863 chr9:129646209-129646210(+) m6A 3'UTR       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZBTB34	Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART4-5p
Interactor2: ZBTB34

Evidence Support:

Strong-Evidence	Luciferase reporter assay
Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).