Basic Information:

  VIRBase ID:  

VHID00306510

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART4-5p:  MIMAT0003412          OXR1:  NM_001198535     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART4-5p	OXR1
miRBase Accession/Entrez ID	MIMAT0003412	55074
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CHEGDD//Nbla00307//TLDC3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OXR1	chr8:107709406(+) A-I      intronic chr8:107709419(+) A-I      intronic chr8:107732777(+) A-I      intronic chr8:107732789(+) A-I      intronic chr8:107304132(+) A-I      intronic chr8:107594144(+) A-I      intronic chr8:107661358(+) A-I      intronic chr8:107736040(+) A-I      intronic chr8:107760932(+) A-I      intronic chr8:107761362(+) A-I      intronic chr8:107761398(+) A-I      intronic chr8:107762584(+) A-I      intronic chr8:107709349(+) A-I      intronic chr8:107709348(+) A-I      intronic chr8:107709347(+) A-I      intronic chr8:107745879(+) A-I      intronic chr8:107542626(+) A-I      intronic chr8:107548435(+) A-I      intronic chr8:107557970(+) A-I      intronic chr8:107600394(+) A-I      intronic chr8:107607530(+) A-I      intronic chr8:107607568(+) A-I      intronic chr8:107607667(+) A-I      intronic chr8:107617794(+) A-I      intronic chr8:107629530(+) A-I      intronic chr8:107629547(+) A-I      intronic chr8:107629579(+) A-I      intronic chr8:107637043(+) A-I      intronic chr8:107637051(+) A-I      intronic chr8:107645405(+) A-I      intronic chr8:107645420(+) A-I      intronic chr8:107645425(+) A-I      intronic chr8:107661310(+) A-I      intronic chr8:107661318(+) A-I      intronic chr8:107661322(+) A-I      intronic chr8:107661326(+) A-I      intronic chr8:107661412(+) A-I      intronic chr8:107699841(+) A-I      intronic chr8:107730880(+) A-I      intronic chr8:107730907(+) A-I      intronic chr8:107730910(+) A-I      intronic chr8:107730913(+) A-I      intronic chr8:107730973(+) A-I      intronic chr8:107730995(+) A-I      intronic chr8:107731016(+) A-I      intronic chr8:107732055(+) A-I      intronic chr8:107732077(+) A-I      intronic chr8:107732216(+) A-I      intronic chr8:107732256(+) A-I      intronic chr8:107732270(+) A-I      intronic chr8:107732273(+) A-I      intronic chr8:107735356(+) A-I      intronic chr8:107735628(+) A-I      intronic chr8:107735708(+) A-I      intronic chr8:107735806(+) A-I      intronic chr8:107735839(+) A-I      intronic chr8:107736087(+) A-I      intronic chr8:107736117(+) A-I      intronic chr8:107736118(+) A-I      intronic chr8:107736248(+) A-I      intronic chr8:107736276(+) A-I      intronic chr8:107745859(+) A-I      intronic chr8:107745962(+) A-I      intronic chr8:107745969(+) A-I      intronic chr8:107745999(+) A-I      intronic chr8:107760923(+) A-I      intronic chr8:107761383(+) A-I      intronic chr8:107761385(+) A-I      intronic chr8:107761387(+) A-I      intronic chr8:107761414(+) A-I      intronic chr8:107761424(+) A-I      intronic chr8:107761460(+) A-I      intronic chr8:107761472(+) A-I      intronic chr8:107761473(+) A-I      intronic chr8:107761526(+) A-I      intronic chr8:107761536(+) A-I      intronic chr8:107762597(+) A-I      intronic chr8:107762610(+) A-I      intronic chr8:107762617(+) A-I      intronic chr8:107762634(+) A-I      intronic chr8:107351602(+) A-I      intronic chr8:107736279(+) A-I      intronic chr8:107760936(+) A-I      intronic chr8:107746298(+) A-I      intronic chr8:107761297(+) A-I      intronic chr8:107761444(+) A-I      intronic chr8:107699827(+) A-I      intronic chr8:107736041(+) A-I      intronic chr8:107760998(+) A-I      intronic chr8:107745975(+) A-I      intronic chr8:107736203(+) A-I      intronic chr8:107735605(+) A-I      intronic chr8:107735727(+) A-I      intronic chr8:107671438(+) A-I      intronic chr8:107736104(+) A-I      intronic chr8:107400924(+) A-I      intronic chr8:107730812(+) A-I      intronic chr8:107745870(+) A-I      intronic chr8:107402183(+) A-I      intronic chr8:107762832(+) A-I      intronic chr8:107402052(+) A-I      intronic chr8:107755699(+) A-I      intronic chr8:107761456(+) A-I      intronic chr8:107351668(+) A-I      intronic chr8:107760853(+) A-I      intronic chr8:107735465(+) A-I      intronic chr8:107441706(+) A-I      intronic chr8:107684520(+) A-I      intronic chr8:107760981(+) A-I      intronic chr8:107735820(+) A-I      intronic chr8:107732133(+) A-I      intronic chr8:107745873(+) A-I      intronic chr8:107746369(+) A-I      intronic chr8:107760938(+) A-I      intronic chr8:107745877(+) A-I      intronic chr8:107379498(+) A-I      intronic chr8:107684451(+) A-I      intronic chr8:107736179(+) A-I      intronic chr8:107671421(+) A-I      intronic chr8:107735442(+) A-I      intronic chr8:107761421(+) A-I      intronic chr8:107729249(+) A-I      intronic chr8:107729280(+) A-I      intronic chr8:107736147(+) A-I      intronic chr8:107736266(+) A-I      intronic chr8:107736249(+) A-I      intronic chr8:107746293(+) A-I      intronic chr8:107731017(+) A-I      intronic chr8:107683116(+) A-I      intronic chr8:107730813(+) A-I      intronic chr8:107745986(+) A-I      intronic chr8:107729293(+) A-I      intronic chr8:107761521(+) A-I      intronic chr8:107736157(+) A-I      intronic chr8:107760946(+) A-I      intronic chr8:107376697(+) A-I      intronic chr8:107732241(+) A-I      intronic chr8:107735615(+) A-I      intronic chr8:107730987(+) A-I      intronic chr8:107761450(+) A-I      intronic chr8:107760827(+) A-I      intronic chr8:107736120(+) A-I      intronic chr8:107732034(+) A-I      intronic chr8:107739721(+) A-I      intronic chr8:107745876(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OXR1	chr8:107674207(+) A-G intron -    22484847 chr8:107731017(+) A-G intron -    22484847 chr8:107732034(+) A-G intron -    22484847 chr8:107732241(+) A-G intron -    22484847 chr8:107735605(+) A-G intron -    22484847 chr8:107735615(+) A-G intron -    22484847 chr8:107736041(+) A-G intron -    22484847 chr8:107736069(+) A-G intron -    22484847 chr8:107736074(+) A-G intron -    22484847 chr8:107736120(+) A-G intron -    22484847 chr8:107736147(+) A-G intron -    22484847 chr8:107736157(+) A-G intron -    22484847 chr8:107736159(+) A-G intron -    22484847 chr8:107736163(+) A-G intron -    22484847 chr8:107736179(+) A-G intron -    22484847 chr8:107736197(+) A-G intron -    22484847 chr8:107736203(+) A-G intron -    22484847 chr8:107736242(+) A-G intron -    22484847 chr8:107736249(+) A-G intron -    22484847 chr8:107736266(+) A-G intron -    22484847 chr8:107745870(+) A-G intron -    22484847 chr8:107745872(+) A-G intron -    22484847 chr8:107745873(+) A-G intron -    22484847 chr8:107745876(+) A-G intron -    22484847 chr8:107745915(+) G-A intron -    22484847 chr8:107745975(+) A-G intron -    22484847 chr8:107745982(+) A-G intron -    22484847 chr8:107746230(+) T-A intron -    22484847 chr8:107746293(+) A-G intron -    22484847 chr8:107746298(+) A-G intron -    22484847 chr8:107760827(+) A-G intron -    22484847 chr8:107760853(+) A-G intron -    22484847 chr8:107760936(+) A-G intron -    22484847 chr8:107760981(+) A-G intron -    22484847 chr8:107760987(+) A-G intron -    22484847 chr8:107760998(+) A-G intron -    22484847 chr8:107761293(+) A-G intron -    22484847 chr8:107761297(+) A-G intron -    22484847 chr8:107761421(+) A-G intron -    22484847 chr8:107761440(+) A-G intron -    22484847 chr8:107761444(+) A-G intron -    22484847 chr8:107761450(+) A-G intron -    22484847 chr8:107761456(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OXR1	chr8:107284210-107284211(+) m6A intron       24284625//25456834//24981863//22608085 chr8:107284259-107284260(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr8:107284265-107284266(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr8:107284337-107284338(+) m6A intron       24284625//24209618//24981863//22608085 chr8:107284357-107284358(+) m6A intron       24284625//24209618//24981863//22608085 chr8:107284383-107284384(+) m6A intron       24284625//24209618//24981863//22608085 chr8:107284395-107284396(+) m6A intron       24284625//24209618//24981863//22608085 chr8:107284419-107284420(+) m6A intron       24284625//24209618//24981863//22608085 chr8:107284459-107284460(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr8:107284464-107284465(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr8:107284557-107284558(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr8:107284719-107284720(+) m6A intron       24284625//24209618//25456834//24981863//22575960//22608085 chr8:107284756-107284757(+) m6A intron       24284625//24209618//25456834//24981863//22575960//22608085 chr8:107284762-107284763(+) m6A intron       24284625//24209618//25456834//24981863//22575960//22608085 chr8:107284774-107284775(+) m6A intron       24284625//24209618//25456834//24981863//22575960//22608085 chr8:107284784-107284785(+) m6A intron       24284625//24209618//25456834//24981863//22575960//22608085 chr8:107284831-107284832(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr8:107284845-107284846(+) m6A intron       24284625//24209618//25456834//24981863//22608085 chr8:107284957-107284958(+) m6A intron       24209618//24981863//22608085 chr8:107284989-107284990(+) m6A intron       - chr8:107371713-107371714(+) m6A 5'UTR       24209618 chr8:107670167-107670168(+) m6A 5'UTR//intron       - chr8:107670218-107670219(+) m6A CDS//intron       - chr8:107670353-107670354(+) m6A CDS//intron       - chr8:107718635-107718636(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr8:107718683-107718684(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085 chr8:107718777-107718778(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr8:107718816-107718817(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr8:107718862-107718863(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr8:107718945-107718946(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr8:107718967-107718968(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr8:107718982-107718983(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr8:107719064-107719065(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr8:107719091-107719092(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22608085 chr8:107719165-107719166(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:107719179-107719180(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:107719206-107719207(+) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:107719229-107719230(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:107719237-107719238(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:107719238-107719239(+) Cm CDS//intron       - chr8:107719260-107719261(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:107719270-107719271(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:107719288-107719289(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:107719293-107719294(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr8:107719362-107719363(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr8:107719511-107719512(+) m6A 3'UTR//intron       24209618//22608085 chr8:107719605-107719606(+) m6A 3'UTR//intron       24209618 chr8:107719891-107719892(+) m6A 3'UTR//intron       24981863 chr8:107719901-107719902(+) m6A 3'UTR//intron       24981863 chr8:107738424-107738425(+) m6A 5'UTR//intron       24981863 chr8:107763206-107763207(+) m6A 3'UTR       24981863 chr8:107763884-107763885(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	OXR1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART4-5p
Interactor2: OXR1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.