Basic Information:

  VIRBase ID:  

VHID00305634

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART4-5p:  MIMAT0003412          STK17B:  NM_004226     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART4-5p	STK17B
miRBase Accession/Entrez ID	MIMAT0003412	9262
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DRAK2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STK17B	chr2:197017773(-) A-I      intronic chr2:197006911(-) A-I      intronic chr2:197012678(-) A-I      intronic chr2:197012672(-) A-I      intronic chr2:197011181(-) A-I      intronic chr2:197023546(-) A-I      intronic chr2:197021767(-) A-I      intronic chr2:197021706(-) A-I      intronic chr2:197006167(-) A-I      intronic chr2:197028655(-) A-I      intronic chr2:197028527(-) A-I      intronic chr2:197027514(-) A-I      intronic chr2:197011084(-) A-I      intronic chr2:197006894(-) A-I      intronic chr2:197007013(-) A-I      intronic chr2:197006952(-) A-I      intronic chr2:197027505(-) A-I      intronic chr2:197027492(-) A-I      intronic chr2:197011111(-) A-I      intronic chr2:197026445(-) A-I      intronic chr2:197026443(-) A-I      intronic chr2:197011171(-) A-I      intronic chr2:197006880(-) A-I      intronic chr2:197027482(-) A-I      intronic chr2:197012552(-) A-I      intronic chr2:197012561(-) A-I      intronic chr2:197026415(-) A-I      intronic chr2:197011165(-) A-I      intronic chr2:197024149(-) A-I      intronic chr2:197012548(-) A-I      intronic chr2:197023658(-) A-I      intronic chr2:197026424(-) A-I      intronic chr2:197026418(-) A-I      intronic chr2:197012623(-) A-I      intronic chr2:197012636(-) A-I      intronic chr2:197023587(-) A-I      intronic chr2:197006220(-) A-I      intronic chr2:197016832(-) A-I      intronic chr2:197016833(-) A-I      intronic chr2:197016999(-) A-I      intronic chr2:197021751(-) A-I      intronic chr2:197012657(-) A-I      intronic chr2:197017759(-) A-I      intronic chr2:197017781(-) A-I      intronic chr2:197017798(-) A-I      intronic chr2:197018779(-) A-I      intronic chr2:197018796(-) A-I      intronic chr2:197017752(-) A-I      intronic chr2:197016916(-) A-I      intronic chr2:197011100(-) A-I      intronic chr2:197012600(-) A-I      intronic chr2:197018906(-) A-I      intronic chr2:197014026(-) A-I      intronic chr2:197007055(-) A-I      intronic chr2:197017002(-) A-I      intronic chr2:197024282(-) A-I      intronic chr2:197011051(-) A-I      intronic chr2:197024235(-) A-I      intronic chr2:197017680(-) A-I      intronic chr2:197017000(-) A-I      intronic chr2:197018846(-) A-I      intronic chr2:197018911(-) A-I      intronic chr2:197016955(-) A-I      intronic chr2:197006373(-) A-I      intronic chr2:197016891(-) A-I      intronic chr2:197016959(-) A-I      intronic chr2:197018875(-) A-I      intronic chr2:197017060(-) A-I      intronic chr2:197016969(-) A-I      intronic chr2:197012604(-) A-I      intronic chr2:197006367(-) A-I      intronic chr2:197016995(-) A-I      intronic chr2:197017082(-) A-I      intronic chr2:197017077(-) A-I      intronic chr2:197010952(-) A-I      intronic chr2:197017795(-) A-I      intronic chr2:197011088(-) A-I      intronic chr2:197016977(-) A-I      intronic chr2:197016885(-) A-I      intronic chr2:197026381(-) A-I      intronic chr2:197017005(-) A-I      intronic chr2:197018736(-) A-I      intronic chr2:197018718(-) A-I      intronic chr2:197006921(-) A-I      intronic chr2:197011020(-) A-I      intronic chr2:197013945(-) A-I      intronic chr2:197010986(-) A-I      intronic chr2:197016942(-) A-I      intronic chr2:197027551(-) A-I      intronic chr2:197014057(-) A-I      intronic chr2:197018830(-) A-I      intronic chr2:197018748(-) A-I      intronic chr2:197006149(-) A-I      intronic chr2:197011038(-) A-I      intronic chr2:197012681(-) A-I      intronic chr2:197005303(-) A-I      intronic chr2:197012584(-) A-I      intronic chr2:197027439(-) A-I      intronic chr2:197018834(-) A-I      intronic chr2:197006271(-) A-I      intronic chr2:197006195(-) A-I      intronic chr2:197006211(-) A-I      intronic chr2:197024199(-) A-I      intronic chr2:197018732(-) A-I      intronic chr2:197018814(-) A-I      intronic chr2:197023652(-) A-I      intronic chr2:197014056(-) A-I      intronic chr2:197011145(-) A-I      intronic chr2:197024163(-) A-I      intronic chr2:197017003(-) A-I      intronic chr2:197018705(-) A-I      intronic chr2:197006874(-) A-I      intronic chr2:197007061(-) A-I      intronic chr2:197018766(-) A-I      intronic chr2:197012620(-) A-I      intronic chr2:197024132(-) A-I      intronic chr2:197010996(-) A-I      intronic chr2:197016106(-) A-I      intronic chr2:197026367(-) A-I      intronic chr2:197024195(-) A-I      intronic chr2:197011194(-) A-I      intronic chr2:197026441(-) A-I      intronic chr2:197024145(-) A-I      intronic chr2:197011152(-) A-I      intronic chr2:197027506(-) A-I      intronic chr2:197006352(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STK17B	chr2:197017795(-) A-I intron -    15342557 chr2:197018402(-) A-I intron -    15342557 chr2:197018717(-) A-I intron -    15342557   //15258596 chr2:197018766(-) A-I intron -    15342557   //15258596 chr2:197018767(-) A-I intron -    15342557   //15258596 chr2:197018801(-) A-I intron -    15342557   //15258596 chr2:197018830(-) A-I intron -    15342557   //15258596 chr2:197018846(-) A-I intron -    15342557   //15258596 chr2:197018875(-) A-I intron -    15342557 chr2:197000389(-) G-C exon 3'UTR    22484847 chr2:197006121(-) A-G intron -    22484847 chr2:197006195(-) A-G intron -    22484847 chr2:197006211(-) A-G intron -    22484847 chr2:197006261(-) A-G intron -    22484847 chr2:197006271(-) A-G intron -    22484847 chr2:197006352(-) A-G intron -    22484847 chr2:197006367(-) A-G intron -    22484847 chr2:197006373(-) A-G intron -    22484847 chr2:197006375(-) A-G intron -    22484847 chr2:197006874(-) A-G intron -    22484847 chr2:197006875(-) A-G intron -    22484847 chr2:197006921(-) A-G intron -    22484847 chr2:197007061(-) A-G intron -    22484847 chr2:197011100(-) A-G intron -    22484847 chr2:197011145(-) A-G intron -    22484847 chr2:197011194(-) A-G intron -    22484847 chr2:197012725(-) A-G intron -    22484847 chr2:197014057(-) A-G intron -    22484847 chr2:197017795(-) A-G intron -    22484847 chr2:197018732(-) A-G intron -    22484847 chr2:197018793(-) A-G intron -    22484847 chr2:197018801(-) A-G intron -    22484847 chr2:197018814(-) A-G intron -    22484847 chr2:197018830(-) A-G intron -    22484847 chr2:197018836(-) A-G intron -    22484847 chr2:197018846(-) A-G intron -    22484847 chr2:197018858(-) A-G intron -    22484847 chr2:197023652(-) A-G intron -    22484847 chr2:197024132(-) A-G intron -    22484847 chr2:197024282(-) A-G intron -    22484847 chr2:197026441(-) A-G intron -    22484847 chr2:197027439(-) A-G intron -    22484847 chr2:197027502(-) A-G intron -    22484847 chr2:197027506(-) A-G intron -    22484847 chr2:197027551(-) A-G intron -    22484847 chr2:197027557(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STK17B	chr2:196999511-196999512(-) m6A 3'UTR       26404942 chr2:196999647-196999648(-) m6A 3'UTR       26404942 chr2:197001026-197001027(-) m6A 3'UTR       26404942 chr2:197001039-197001040(-) m6A 3'UTR       26404942 chr2:197001889-197001890(-) m6A 3'UTR       27773535 chr2:197002145-197002146(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr2:197002194-197002195(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chr2:197002273-197002274(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chr2:197002292-197002293(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chr2:197002316-197002317(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chr2:197002321-197002322(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chr2:197002352-197002353(-) m6A CDS       24284625//24981863//28052920//26404942//27773535//27371828//22608085 chr2:197002370-197002371(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085 chr2:197002390-197002391(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085 chr2:197002399-197002400(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085 chr2:197002446-197002447(-) m6A CDS       24981863//26404942//22608085 chr2:197004376-197004377(-) m6A CDS       24981863//27773535//22608085 chr2:197004407-197004408(-) m6A CDS       27773535 chr2:197004452-197004453(-) m6A CDS       27773535 chr2:197021353-197021354(-) m6A CDS       24981863//26404942//27773535 chr2:197028027-197028028(-) m6A CDS       26404942//27773535 chr2:197028124-197028125(-) m6A 5'UTR       27773535 chr2:197036074-197036075(-) m6A 5'UTR//intron       27371828 chr2:197036108-197036109(-) m6A 5'UTR//intron       27371828 chr2:197036142-197036143(-) m6A 5'UTR//intron       24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	STK17B	Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART4-5p
Interactor2: STK17B

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.