Basic Information:

  VIRBase ID:  

VHID00305356

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART4-5p:  MIMAT0003412          SOX12:  NM_006943     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART4-5p	SOX12
miRBase Accession/Entrez ID	MIMAT0003412	6666
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	SOX22

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SOX12	chr20:306310-306311(+) m6A 5'UTR       24284625//24209618//24981863 chr20:306377-306378(+) m6A 5'UTR       24284625//24209618//24981863 chr20:306624-306625(+) m6A CDS       24284625//24209618//25456834//24981863//27773536//22575960//22608085 chr20:306670-306671(+) m6A CDS       24284625//24209618//25456834//24981863//27773536//22575960//22608085 chr20:306746-306747(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:306815-306816(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:306884-306885(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:307108-307109(+) m6A CDS       24284625//24209618//25456834//24981863//27773536//22575960//22608085 chr20:307161-307162(+) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr20:307364-307365(+) m6A CDS       24284625//24209618//25456834//24981863//27773536//22575960//22608085 chr20:307391-307392(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:307433-307434(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:307472-307473(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:307496-307497(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:307548-307549(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:307664-307665(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr20:307683-307684(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr20:307808-307809(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr20:307857-307858(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr20:308249-308250(+) m6A 3'UTR       24284625 chr20:308420-308421(+) m6A 3'UTR       24284625//24981863 chr20:308433-308434(+) m6A 3'UTR       24284625//24981863 chr20:308440-308441(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr20:308469-308470(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr20:308621-308622(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:308651-308652(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:308686-308687(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:308700-308701(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:308718-308719(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:308739-308740(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:309023-309024(+) m6A 3'UTR       24284625//24209618 chr20:309047-309048(+) m6A 3'UTR       24284625//24209618 chr20:309188-309189(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr20:309207-309208(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr20:309266-309267(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr20:309326-309327(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr20:309348-309349(+) m6A 3'UTR       24284625//24981863//22608085 chr20:309422-309423(+) m6A 3'UTR       24981863 chr20:309769-309770(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SOX12	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART4-5p
Interactor2: SOX12

Evidence Support:

Weak-Evidence	HITS-CLIP
Prediction-Evidence	cRep//miRanda//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22473208	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).