Detail Information

Basic Information:


  VIRBase ID:  

VHID00304642

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART4-5p:           BACH1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART4-5p BACH1
miRBase
Accession/Entrez ID		 MIMAT0003412 571
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - BACH-1//BTBD24

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BACH1
chr21:30724971(+) A-I      ncRNA
chr21:30730859(+) A-I      intronic
chr21:30730865(+) A-I      intronic
chr21:30730874(+) A-I      intronic
chr21:30730900(+) A-I      intronic
chr21:30731002(+) A-I      intronic
chr21:30731011(+) A-I      intronic
chr21:30710135(+) A-I      intronic
chr21:30724515(+) A-I      intronic
chr21:30731043(+) A-I      intronic
chr21:30724443(+) A-I      intronic
chr21:30730909(+) A-I      intronic
chr21:30730903(+) A-I      intronic
chr21:30724637(+) A-I      intronic
chr21:30730901(+) A-I      intronic
chr21:30730910(+) A-I      intronic
chr21:30731074(+) A-I      intronic
chr21:30731018(+) A-I      intronic
chr21:30731016(+) A-I      intronic
chr21:30730967(+) A-I      intronic
chr21:30730875(+) A-I      intronic
chr21:30712017(+) A-I      intronic
chr21:30712018(+) A-I      intronic
chr21:30712167(+) A-I      intronic
chr21:30725126(+) A-I      intronic
chr21:30724395(+) A-I      intronic
chr21:30725286(+) A-I      intronic
chr21:30725133(+) A-I      intronic
chr21:30724493(+) A-I      intronic
chr21:30724550(+) A-I      intronic
chr21:30730899(+) A-I      intronic
chr21:30730884(+) A-I      intronic
chr21:30730835(+) A-I      intronic
chr21:30724972(+) A-I      ncRNA
chr21:30710129(+) A-I      intronic
chr21:30731006(+) A-I      intronic
chr21:30730946(+) A-I      intronic
chr21:30725217(+) A-I      intronic
chr21:30710829(+) A-I      intronic
chr21:30725353(+) A-I      intronic
chr21:30730941(+) A-I      intronic
chr21:30724450(+) A-I      intronic
chr21:30724559(+) A-I      intronic
chr21:30710758(+) A-I      intronic
chr21:30724476(+) A-I      intronic
chr21:30724509(+) A-I      intronic
chr21:30725088(+) A-I      intronic
chr21:30730950(+) A-I      intronic
chr21:30724475(+) A-I      intronic
chr21:30725442(+) A-I      intronic
chr21:30710835(+) A-I      intronic
chr21:30730808(+) A-I      intronic
chr21:30725084(+) A-I      intronic
chr21:30725308(+) A-I      intronic
chr21:30730896(+) A-I      intronic
chr21:30710718(+) A-I      intronic
chr21:30730940(+) A-I      intronic
chr21:30725296(+) A-I      intronic
chr21:30730914(+) A-I      intronic
chr21:30725172(+) A-I      intronic
chr21:30710205(+) A-I      intronic
chr21:30724942(+) A-I      ncRNA
chr21:30724981(+) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BACH1
chr21:30710726(+) A-I intron -    22327324
chr21:30710726(+) A-G intron -    22484847
chr21:30725281(+) A-G intron -    22484847
chr21:30725296(+) A-G intron -    22484847
chr21:30725308(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BACH1
chr21:30660396-30660397(+) m6A 5'UTR//intron       24981863
chr21:30693726-30693727(+) m6A CDS       24284625
chr21:30698539-30698540(+) m6A CDS       24209618//24981863//26404942//22575960//22608085
chr21:30698551-30698552(+) m6A CDS       24209618//24981863//26404942//22575960//22608085
chr21:30698601-30698602(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698612-30698613(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698626-30698627(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698643-30698644(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698685-30698686(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698699-30698700(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698746-30698747(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698760-30698761(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698850-30698851(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30698887-30698888(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699005-30699006(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699091-30699092(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699101-30699102(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699169-30699170(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699222-30699223(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30699329-30699330(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30699370-30699371(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30699422-30699423(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699485-30699486(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699498-30699499(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr21:30701937-30701938(+) m6A CDS       24209618//22608085
chr21:30701971-30701972(+) m6A CDS       24284625//24209618//22608085
chr21:30714779-30714780(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714789-30714790(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714799-30714800(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714841-30714842(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714931-30714932(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30715002-30715003(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr21:30715081-30715082(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr21:30715154-30715155(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr21:30715175-30715176(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr21:30715326-30715327(+) m6A 3'UTR//intron       24209618//24981863//22608085
chr21:30715383-30715384(+) m6A 3'UTR//intron       24209618//24981863//26404942//22608085
chr21:30715392-30715393(+) m6A 3'UTR//intron       24209618//24981863//26404942//22608085
chr21:30715463-30715464(+) m6A 3'UTR//intron       24284625//24981863//26404942//22608085
chr21:30715478-30715479(+) m6A 3'UTR//intron       24284625//24981863//26404942//22608085
chr21:30715499-30715500(+) m6A 3'UTR//intron       24284625//24981863//26404942//22608085
chr21:30715809-30715810(+) m6A 3'UTR//intron       24209618//24981863
chr21:30715902-30715903(+) m6A 3'UTR//intron       24209618//24981863
chr21:30715948-30715949(+) m6A 3'UTR//intron       24981863
chr21:30718077-30718078(+) m6A 3'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BACH1
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART4-5p
Interactor2: BACH1

Evidence Support:


Strong-Evidence Dual luciferase reporter assay
Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase//VmiReg

References:


[1]PMID 23170179 Target region 3'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays.
[2]PMID 22291592 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression Downregulation
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description For each of them, direct interactions between 3'UTR and EBV miRNAs were confirmed by luciferase assay but no functional assay has been performed so far (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation (PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) or RNA immunoprecipitation and microarray (RIP-Chip) techniques. Validation of these targets was done using luciferase reporter assays.

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