Detail Information

Basic Information:


  VIRBase ID:  

VHID00303176

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART3-3p:           SYNJ2BP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART3-3p SYNJ2BP
miRBase
Accession/Entrez ID		 MIMAT0003411 55333
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - ARIP2//OMP25

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SYNJ2BP
chr14:70852293(-) A-I      intronic
chr14:70852294(-) A-I      intronic
chr14:70852301(-) A-I      intronic
chr14:70875730(-) A-I      intronic
chr14:70838363(-) A-I      3'UTR
chr14:70834192(-) A-I      3'UTR
chr14:70838257(-) A-I      3'UTR
chr14:70838260(-) A-I      3'UTR
chr14:70838305(-) A-I      3'UTR
chr14:70838331(-) A-I      3'UTR
chr14:70838376(-) A-I      3'UTR
chr14:70838401(-) A-I      3'UTR
chr14:70864757(-) A-I      intronic
chr14:70852291(-) A-I      intronic
chr14:70854375(-) A-I      intronic
chr14:70847162(-) A-I      intronic
chr14:70845236(-) A-I      intronic
chr14:70852179(-) A-I      intronic
chr14:70848947(-) A-I      intronic
chr14:70848841(-) A-I      intronic
chr14:70863106(-) A-I      intronic
chr14:70852317(-) A-I      intronic
chr14:70848780(-) A-I      intronic
chr14:70854526(-) A-I      intronic
chr14:70845284(-) A-I      intronic
chr14:70845252(-) A-I      intronic
chr14:70854501(-) A-I      intronic
chr14:70876593(-) A-I      intronic
chr14:70852371(-) A-I      intronic
chr14:70875851(-) A-I      intronic
chr14:70875724(-) A-I      intronic
chr14:70854465(-) A-I      intronic
chr14:70854392(-) A-I      intronic
chr14:70854546(-) A-I      intronic
chr14:70869333(-) A-I      intronic
chr14:70875780(-) A-I      intronic
chr14:70854448(-) A-I      intronic
chr14:70854384(-) A-I      intronic
chr14:70845288(-) A-I      intronic
chr14:70854436(-) A-I      intronic
chr14:70854399(-) A-I      intronic
chr14:70838144(-) A-I      3'UTR
chr14:70834235(-) A-I      3'UTR
chr14:70838371(-) A-I      3'UTR
chr14:70835925(-) A-I      3'UTR
chr14:70836005(-) A-I      3'UTR
chr14:70835948(-) A-I      3'UTR
chr14:70836017(-) A-I      3'UTR
chr14:70838318(-) A-I      3'UTR
chr14:70834179(-) A-I      3'UTR
chr14:70834051(-) A-I      3'UTR
chr14:70838198(-) A-I      3'UTR
chr14:70834197(-) A-I      3'UTR
chr14:70835910(-) A-I      3'UTR
chr14:70834217(-) A-I      3'UTR
chr14:70838354(-) A-I      3'UTR
chr14:70838390(-) A-I      3'UTR
chr14:70838330(-) A-I      3'UTR
chr14:70834109(-) A-I      3'UTR
chr14:70838329(-) A-I      3'UTR
chr14:70838268(-) A-I      3'UTR
chr14:70834227(-) A-I      3'UTR
chr14:70834157(-) A-I      3'UTR
chr14:70836058(-) A-I      3'UTR
chr14:70835891(-) A-I      3'UTR
chr14:70836014(-) A-I      3'UTR
chr14:70835930(-) A-I      3'UTR
chr14:70838368(-) A-I      3'UTR
chr14:70834277(-) A-I      3'UTR
chr14:70848901(-) A-I      intronic
chr14:70855798(-) A-I      intronic
chr14:70875865(-) A-I      intronic
chr14:70868070(-) A-I      intronic
chr14:70875683(-) A-I      intronic
chr14:70868567(-) A-I      intronic
chr14:70845315(-) A-I      intronic
chr14:70854292(-) A-I      intronic
chr14:70841916(-) A-I      intronic
chr14:70852254(-) A-I      intronic
chr14:70845300(-) A-I      intronic
chr14:70855797(-) A-I      intronic
chr14:70876723(-) A-I      intronic
chr14:70875860(-) A-I      intronic
chr14:70848764(-) A-I      intronic
chr14:70874071(-) A-I      intronic
chr14:70852202(-) A-I      intronic
chr14:70848760(-) A-I      intronic
chr14:70855719(-) A-I      intronic
chr14:70842116(-) A-I      intronic
chr14:70854367(-) A-I      intronic
chr14:70852214(-) A-I      intronic
chr14:70845298(-) A-I      intronic
chr14:70855741(-) A-I      intronic
chr14:70854542(-) A-I      intronic
chr14:70869332(-) A-I      intronic
chr14:70845281(-) A-I      intronic
chr14:70875307(-) A-I      intronic
chr14:70871599(-) A-I      intronic
chr14:70863107(-) A-I      intronic
chr14:70875689(-) A-I      intronic
chr14:70868531(-) A-I      intronic
chr14:70838197(-) A-I      3'UTR
chr14:70834099(-) A-I      3'UTR
chr14:70834130(-) A-I      3'UTR
chr14:70836006(-) A-I      3'UTR
chr14:70838324(-) A-I      3'UTR
chr14:70838273(-) A-I      3'UTR
chr14:70838192(-) A-I      3'UTR
chr14:70838274(-) A-I      3'UTR
chr14:70834222(-) A-I      3'UTR
chr14:70834232(-) A-I      3'UTR
chr14:70835974(-) A-I      3'UTR
chr14:70834055(-) A-I      3'UTR
chr14:70834196(-) A-I      3'UTR
chr14:70836024(-) A-I      3'UTR
chr14:70834113(-) A-I      3'UTR
chr14:70836004(-) A-I      3'UTR
chr14:70834253(-) A-I      3'UTR
chr14:70834122(-) A-I      3'UTR
chr14:70834059(-) A-I      3'UTR
chr14:70834087(-) A-I      3'UTR
chr14:70838202(-) A-I      3'UTR
chr14:70834116(-) A-I      3'UTR
chr14:70836071(-) A-I      3'UTR
chr14:70835958(-) A-I      3'UTR
chr14:70836039(-) A-I      3'UTR
chr14:70834155(-) A-I      3'UTR
chr14:70834167(-) A-I      3'UTR
chr14:70836027(-) A-I      3'UTR
chr14:70838937(-) A-I      3'UTR
chr14:70838264(-) A-I      3'UTR
chr14:70835982(-) A-I      3'UTR
chr14:70838159(-) A-I      3'UTR
chr14:70835987(-) A-I      3'UTR
chr14:70838369(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SYNJ2BP
chr14:70833421-70833422(-) Am 3'UTR       -
chr14:70838156-70838157(-) m6A 3'UTR       24284625//25456834//24981863//22608085
chr14:70838225-70838226(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22608085
chr14:70838231-70838232(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22608085
chr14:70838240-70838241(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22608085
chr14:70838293-70838294(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22608085
chr14:70838328-70838329(-) m6A 3'UTR       24284625//25456834//24981863//22608085
chr14:70838351-70838352(-) m6A 3'UTR       24284625//25456834//24981863//22608085
chr14:70838492-70838493(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22608085
chr14:70838506-70838507(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr14:70838541-70838542(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr14:70838578-70838579(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr14:70838589-70838590(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr14:70838605-70838606(-) m6A 3'UTR       24284625//24981863//22608085
chr14:70838649-70838650(-) m6A 3'UTR       24284625//24981863//22608085
chr14:70838730-70838731(-) m6A 3'UTR       24284625//22608085
chr14:70838814-70838815(-) m6A 3'UTR       24284625//27773535//22608085
chr14:70838887-70838888(-) m6A 3'UTR       24284625//24981863//27773535
chr14:70838910-70838911(-) m6A 3'UTR       24981863//27773535
chr14:70838986-70838987(-) m6A 3'UTR       24981863//22608085
chr14:70839045-70839046(-) m6A 3'UTR       24981863//22608085
chr14:70839065-70839066(-) m6A 3'UTR       24981863//22608085
chr14:70839460-70839461(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr14:70839489-70839490(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr14:70839501-70839502(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr14:70839513-70839514(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr14:70839581-70839582(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr14:70839703-70839704(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr14:70839804-70839805(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr14:70839821-70839822(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr14:70839830-70839831(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr14:70842441-70842442(-) m6A CDS//exon       24284625//27773535//27371828//22608085
chr14:70842465-70842466(-) m6A CDS//exon       24284625//27773535//27371828
chr14:70842474-70842475(-) m6A CDS//exon       24284625//27773535//27371828
chr14:70883681-70883682(-) m6A 5'UTR//exon       24981863
chr14:70883774-70883775(-) m6A exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SYNJ2BP
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART3-3p
Interactor2: SYNJ2BP

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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