Basic Information:

  VIRBase ID:  

VHID00302893

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART3-3p:  MIMAT0003411          CLEC2D:  NR_036693     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART3-3p	CLEC2D
miRBase Accession/Entrez ID	MIMAT0003411	29121
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CLAX//LLT1//OCIL

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CLEC2D	chr12:9844887(+) A-I      intronic chr12:9844796(+) A-I      intronic chr12:9841236(+) A-I      intronic chr12:9841204(+) A-I      intronic chr12:9841164(+) A-I      intronic chr12:9841163(+) A-I      intronic chr12:9841148(+) A-I      intronic chr12:9844918(+) A-I      intronic chr12:9844906(+) A-I      intronic chr12:9844859(+) A-I      intronic chr12:9841224(+) A-I      intronic chr12:9844806(+) A-I      intronic chr12:9844920(+) A-I      intronic chr12:9841184(+) A-I      intronic chr12:9844898(+) A-I      intronic chr12:9844916(+) A-I      intronic chr12:9844893(+) A-I      intronic chr12:9841159(+) A-I      intronic chr12:9844812(+) A-I      intronic chr12:9831248(+) A-I      intronic chr12:9841138(+) A-I      intronic chr12:9844915(+) A-I      intronic chr12:9841255(+) A-I      intronic chr12:9831414(+) A-I      intronic chr12:9828064(+) A-I      intronic chr12:9844849(+) A-I      intronic chr12:9831273(+) A-I      intronic chr12:9841176(+) A-I      intronic chr12:9841081(+) A-I      intronic chr12:9841217(+) A-I      intronic chr12:9841221(+) A-I      intronic chr12:9841307(+) A-I      intronic chr12:9844825(+) A-I      intronic chr12:9844833(+) A-I      intronic chr12:9844758(+) A-I      intronic chr12:9831373(+) A-I      intronic chr12:9844958(+) A-I      intronic chr12:9844956(+) A-I      intronic chr12:9844879(+) A-I      intronic chr12:9841168(+) A-I      intronic chr12:9841080(+) A-I      intronic chr12:9844775(+) A-I      intronic chr12:9844871(+) A-I      intronic chr12:9844861(+) A-I      intronic chr12:9841194(+) A-I      intronic chr12:9844945(+) A-I      intronic chr12:9841094(+) A-I      intronic chr12:9844768(+) A-I      intronic chr12:9844970(+) A-I      intronic chr12:9831433(+) A-I      intronic chr12:9831733(+) A-I      intronic chr12:9841113(+) A-I      intronic chr12:9844809(+) A-I      intronic chr12:9841257(+) A-I      intronic chr12:9828058(+) A-I      intronic chr12:9841156(+) A-I      intronic chr12:9841154(+) A-I      intronic chr12:9841208(+) A-I      intronic chr12:9844897(+) A-I      intronic chr12:9823884(+) A-I      intronic chr12:9844857(+) A-I      intronic chr12:9841155(+) A-I      intronic chr12:9844950(+) A-I      intronic chr12:9844811(+) A-I      intronic chr12:9844873(+) A-I      intronic chr12:9841186(+) A-I      intronic chr12:9844858(+) A-I      intronic chr12:9831279(+) A-I      intronic chr12:9841268(+) A-I      intronic chr12:9841261(+) A-I      intronic chr12:9850784(+) A-I      3'UTR chr12:9850755(+) A-I      3'UTR chr12:9850787(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CLEC2D	chr12:9841080(+) A-I intron -    22327324 chr12:9841186(+) A-I intron -    22327324 chr12:9841208(+) A-I intron -    22327324 chr12:9841217(+) A-I intron -    22327324 chr12:9841261(+) A-I intron -    22327324 chr12:9841268(+) A-I intron -    22327324 chr12:9844809(+) A-I intron -    22327324 chr12:9844857(+) A-I intron -    22327324 chr12:9844879(+) A-I intron -    22327324 chr12:9850784(+) A-I intron -    21960545 chr12:9846013(+) A-G intron -    21725310 chr12:9830325(+) A-T intron -    22484847 chr12:9841080(+) A-G intron -    22484847 chr12:9841094(+) A-G intron -    22484847 chr12:9841113(+) A-G intron -    22484847 chr12:9841138(+) A-G intron -    22484847 chr12:9841154(+) A-G intron -    22484847 chr12:9841155(+) A-G intron -    22484847 chr12:9841168(+) A-G intron -    22484847 chr12:9841176(+) A-G intron -    22484847 chr12:9841186(+) A-G intron -    22484847 chr12:9841194(+) A-G intron -    22484847 chr12:9841208(+) A-G intron -    22484847 chr12:9841255(+) A-G intron -    22484847 chr12:9841257(+) A-G intron -    22484847 chr12:9841261(+) A-G intron -    22484847 chr12:9841268(+) A-G intron -    22484847 chr12:9844811(+) A-G intron -    22484847 chr12:9844812(+) A-G intron -    22484847 chr12:9844825(+) A-G intron -    22484847 chr12:9844849(+) A-G intron -    22484847 chr12:9844857(+) A-G intron -    22484847 chr12:9844871(+) A-G intron -    22484847 chr12:9844879(+) A-G intron -    22484847 chr12:9844915(+) A-G intron -    22484847 chr12:9844945(+) A-G intron -    22484847 chr12:9844956(+) A-G intron -    22484847 chr12:9844958(+) A-G intron -    22484847 chr12:9830330(+) G-T intron -    22484847 chr12:9830409(+) T-C intron -    22484847 chr12:9831273(+) A-G intron -    22484847 chr12:9831279(+) A-G intron -    22484847 chr12:9831373(+) A-G intron -    22484847 chr12:9841081(+) A-G intron -    22484847 chr12:9841156(+) A-G intron -    22484847 chr12:9841159(+) A-G intron -    22484847 chr12:9841319(+) T-A intron -    22484847 chr12:9844758(+) A-G intron -    22484847 chr12:9844768(+) A-G intron -    22484847 chr12:9844819(+) T-C intron -    22484847 chr12:9844833(+) A-G intron -    22484847 chr12:9844858(+) A-G intron -    22484847 chr12:9844950(+) A-G intron -    22484847 chr12:9844970(+) A-G intron -    22484847 chr12:9846481(+) A-G intron -    22484847 chr12:9846526(+) T-C intron -    22484847 chr12:9846527(+) G-A intron -    22484847 chr12:9846539(+) C-T intron -    22484847 chr12:9846690(+) G-T intron -    22484847 chr12:9846692(+) G-C intron -    22484847 chr12:9846693(+) A-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CLEC2D	chr12:9821376-9821377(+) m6A exon//intron       26404942 chr12:9822318-9822319(+) m6A 5'UTR//intron       26404942 chr12:9822358-9822359(+) m6A CDS//intron       26404942 chr12:9822385-9822386(+) m6A CDS//intron       26404942 chr12:9826629-9826630(+) m6A 5'UTR//intron       26404942 chr12:9826643-9826644(+) m6A 5'UTR//intron       26404942 chr12:9847513-9847514(+) m6A 3'UTR       26404942 chr12:9847690-9847691(+) m6A 3'UTR       22608085 chr12:9847817-9847818(+) m6A 3'UTR       22608085 chr12:9847831-9847832(+) m6A 3'UTR       24209618//26404942//22608085 chr12:9847864-9847865(+) m6A 3'UTR       24209618//26404942 chr12:9847870-9847871(+) m6A 3'UTR       24209618//26404942 chr12:9847995-9847996(+) m6A 3'UTR       - chr12:9848001-9848002(+) m6A 3'UTR       22608085 chr12:9848025-9848026(+) m6A 3'UTR       22608085 chr12:9848044-9848045(+) m6A 3'UTR       22608085 chr12:9848096-9848097(+) m6A 3'UTR       25456834//22608085 chr12:9848145-9848146(+) m6A 3'UTR       22608085 chr12:9848273-9848274(+) m6A 3'UTR       22608085 chr12:9848276-9848277(+) Y 3'UTR       26075521 chr12:9848316-9848317(+) m6A 3'UTR       22608085 chr12:9848379-9848380(+) m6A 3'UTR       24981863//22608085 chr12:9848436-9848437(+) m6A 3'UTR       22608085 chr12:9848579-9848580(+) m6A 3'UTR       22608085 chr12:9848586-9848587(+) m6A 3'UTR       22608085 chr12:9848613-9848614(+) m6A 3'UTR       24981863//22608085 chr12:9848631-9848632(+) m6A 3'UTR       24981863 chr12:9848650-9848651(+) m6A 3'UTR       - chr12:9848678-9848679(+) m6A 3'UTR       - chr12:9848737-9848738(+) m6A 3'UTR       - chr12:9848922-9848923(+) m6A 3'UTR       - chr12:9849011-9849012(+) m6A 3'UTR       - chr12:9849059-9849060(+) m6A 3'UTR       - chr12:9849081-9849082(+) m6A 3'UTR       - chr12:9849100-9849101(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CLEC2D	Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART3-3p
Interactor2: CLEC2D

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay
Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VmiReg

References:

[1]PMID	23170179	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	In addition, CLEC2D/LLT1 was identified as a target of BART1 and BART3 by PAR-CLIP.

[2]PMID	22291592	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	Downregulation
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).