Detail Information

Basic Information:


  VIRBase ID:  

VHID00302733

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART3-3p:           BRD4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART3-3p BRD4
miRBase
Accession/Entrez ID		 MIMAT0003411 23476
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - CAP//HUNK1//HUNKI//MCAP

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BRD4
chr19:15385865(-) A-I      intronic
chr19:15389924(-) A-I      intronic
chr19:15389889(-) A-I      intronic
chr19:15389884(-) A-I      intronic
chr19:15389870(-) A-I      intronic
chr19:15389868(-) A-I      intronic
chr19:15389856(-) A-I      intronic
chr19:15389853(-) A-I      intronic
chr19:15389845(-) A-I      intronic
chr19:15389829(-) A-I      intronic
chr19:15389788(-) A-I      intronic
chr19:15389749(-) A-I      intronic
chr19:15389731(-) A-I      intronic
chr19:15389715(-) A-I      intronic
chr19:15388870(-) A-I      intronic
chr19:15388860(-) A-I      intronic
chr19:15388753(-) A-I      intronic
chr19:15388515(-) A-I      intronic
chr19:15388489(-) A-I      intronic
chr19:15388421(-) A-I      intronic
chr19:15388367(-) A-I      intronic
chr19:15386758(-) A-I      intronic
chr19:15386755(-) A-I      intronic
chr19:15386748(-) A-I      intronic
chr19:15386729(-) A-I      intronic
chr19:15386620(-) A-I      intronic
chr19:15386600(-) A-I      intronic
chr19:15386561(-) A-I      intronic
chr19:15385902(-) A-I      intronic
chr19:15385897(-) A-I      intronic
chr19:15385883(-) A-I      intronic
chr19:15385852(-) A-I      intronic
chr19:15385849(-) A-I      intronic
chr19:15385848(-) A-I      intronic
chr19:15385759(-) A-I      intronic
chr19:15385755(-) A-I      intronic
chr19:15385746(-) A-I      intronic
chr19:15385742(-) A-I      intronic
chr19:15373490(-) A-I      intronic
chr19:15373458(-) A-I      intronic
chr19:15373451(-) A-I      intronic
chr19:15385737(-) A-I      intronic
chr19:15385830(-) A-I      intronic
chr19:15369613(-) A-I      intronic
chr19:15369205(-) A-I      intronic
chr19:15369227(-) A-I      intronic
chr19:15369232(-) A-I      intronic
chr19:15369233(-) A-I      intronic
chr19:15369259(-) A-I      intronic
chr19:15369426(-) A-I      intronic
chr19:15369429(-) A-I      intronic
chr19:15369504(-) A-I      intronic
chr19:15369532(-) A-I      intronic
chr19:15369572(-) A-I      intronic
chr19:15372501(-) A-I      intronic
chr19:15372626(-) A-I      intronic
chr19:15373333(-) A-I      intronic
chr19:15389340(-) A-I      intronic
chr19:15386652(-) A-I      intronic
chr19:15389791(-) A-I      intronic
chr19:15386792(-) A-I      intronic
chr19:15388514(-) A-I      intronic
chr19:15389813(-) A-I      intronic
chr19:15389901(-) A-I      intronic
chr19:15389846(-) A-I      intronic
chr19:15389680(-) A-I      intronic
chr19:15386655(-) A-I      intronic
chr19:15386761(-) A-I      intronic
chr19:15369439(-) A-I      intronic
chr19:15389859(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BRD4
chr19:15347667-15347668(-) m6A 3'UTR       27773535
chr19:15347739-15347740(-) m6A 3'UTR       27773535
chr19:15347781-15347782(-) m6A 3'UTR       27773535
chr19:15347898-15347899(-) m6A 3'UTR       27773535//27371828
chr19:15347910-15347911(-) m6A 3'UTR       27773535//27371828
chr19:15347933-15347934(-) m6A 3'UTR       27773535//27371828
chr19:15348104-15348105(-) m6A 3'UTR       24981863//27773535
chr19:15348132-15348133(-) m6A 3'UTR       24981863//27773535
chr19:15348173-15348174(-) m6A 3'UTR       24981863//27773535
chr19:15348178-15348179(-) m6A 3'UTR       24981863//27773535
chr19:15348222-15348223(-) m6A 3'UTR       27773535
chr19:15348269-15348270(-) m6A 3'UTR       27773535
chr19:15348656-15348657(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:15348845-15348846(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr19:15348918-15348919(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr19:15348995-15348996(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr19:15349147-15349148(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr19:15349608-15349609(-) m6A CDS       24284625//24209618//27371828//27773536
chr19:15350058-15350059(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350222-15350223(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350235-15350236(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350245-15350246(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr19:15350723-15350724(-) m6A CDS       24284625//24209618//24981863//27773535
chr19:15353724-15353725(-) m6A CDS       24284625//24209618//24981863//28052920//27773535
chr19:15354190-15354191(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828
chr19:15357396-15357397(-) m6A exon//intron       27773535
chr19:15357421-15357422(-) m6A exon//intron       27773535
chr19:15357956-15357957(-) m6A 3'UTR//intron       27773535
chr19:15358177-15358178(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:15358190-15358191(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:15358224-15358225(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:15358241-15358242(-) m6A 3'UTR//intron       24981863//22608085
chr19:15358300-15358301(-) m6A 3'UTR//intron       24284625
chr19:15358439-15358440(-) m6A 3'UTR//intron       24284625//24981863
chr19:15358491-15358492(-) m6A 3'UTR//intron       24284625//24981863
chr19:15359615-15359616(-) Cm 3'UTR//intron       -
chr19:15366182-15366183(-) m6A CDS       27773535//22575960
chr19:15366292-15366293(-) m6A CDS       24981863//27773535//22575960
chr19:15366340-15366341(-) m6A CDS       24981863//27773535//22575960
chr19:15366924-15366925(-) m6A CDS       24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr19:15367000-15367001(-) m6A CDS//exon       25456834//24981863//27773535//27371828//27773536//22608085
chr19:15367024-15367025(-) m6A CDS//exon       25456834//24981863//27773535//27371828//27773536//22608085
chr19:15367841-15367842(-) m6A CDS//exon       27773535//22575960
chr19:15374353-15374354(-) m6A CDS//exon       27773535
chr19:15374962-15374963(-) m6A exon//intron       27773535
chr19:15375186-15375187(-) m6A exon//intron       24284625//27773535
chr19:15375230-15375231(-) m6A CDS       24284625//27773535
chr19:15375439-15375440(-) m6A CDS       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960
chr19:15375483-15375484(-) m6A CDS       24284625//25456834//24981863//28052920//26404942//27773535//27371828//27773536
chr19:15375548-15375549(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828
chr19:15376307-15376308(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr19:15376321-15376322(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960
chr19:15376385-15376386(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15376391-15376392(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15376420-15376421(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15376443-15376444(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15376451-15376452(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15378229-15378230(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15378280-15378281(-) m6A 3'UTR//CDS       24981863//26404942//27773535//27371828
chr19:15379813-15379814(-) m6A CDS//exon       27773535
chr19:15383632-15383633(-) m6A CDS//exon       24284625//26404942//27773535
chr19:15383682-15383683(-) m6A CDS//exon       24284625//24981863//28052920//26404942//27773535
chr19:15383693-15383694(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15383732-15383733(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15383762-15383763(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828
chr19:15383843-15383844(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15383850-15383851(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828
chr19:15386491-15386492(-) m6A 5'UTR//intron       24209618//24981863//27773535//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BRD4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART3-3p
Interactor2: BRD4

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


[1]PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.
[2]PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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