Detail Information

Basic Information:


  VIRBase ID:  

VHID00302723

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART3-3p:           DICER1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART3-3p DICER1
miRBase
Accession/Entrez ID		 MIMAT0003411 23405
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - DCR1//Dicer//Dicer1e//GLOW//HERNA//K12H4.8-LIKE//MNG1//RMSE2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DICER1
chr14:95617269(-) A-I      intronic
chr14:95617234(-) A-I      intronic
chr14:95617267(-) A-I      intronic
chr14:95617338(-) A-I      intronic
chr14:95617317(-) A-I      intronic
chr14:95608532(-) A-I      intronic
chr14:95614285(-) A-I      intronic
chr14:95617280(-) A-I      intronic
chr14:95597526(-) A-I      intronic
chr14:95616760(-) A-I      intronic
chr14:95616576(-) A-I      intronic
chr14:95616771(-) A-I      intronic
chr14:95617357(-) A-I      intronic
chr14:95617355(-) A-I      intronic
chr14:95615385(-) A-I      intronic
chr14:95616741(-) A-I      intronic
chr14:95617292(-) A-I      intronic
chr14:95613681(-) A-I      intronic
chr14:95597535(-) A-I      intronic
chr14:95617300(-) A-I      intronic
chr14:95617325(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DICER1
chr14:95615385(-) A-G intron -    22484847
chr14:95616576(-) A-G intron -    22484847
chr14:95617280(-) A-G intron -    22484847
chr14:95617300(-) A-G intron -    22484847
chr14:95617325(-) A-G intron -    22484847
chr14:95617355(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DICER1
chr14:95552701-95552702(-) m6A 3'UTR       27773535
chr14:95553018-95553019(-) m6A 3'UTR       27773535
chr14:95553532-95553533(-) m6A 3'UTR       -
chr14:95554128-95554129(-) m6A 3'UTR       24981863
chr14:95555754-95555755(-) m6A 3'UTR//intron       27773535
chr14:95555818-95555819(-) m6A 3'UTR//intron       27773535
chr14:95555825-95555826(-) m6A 3'UTR//intron       27773535
chr14:95556649-95556650(-) m6A 3'UTR//intron       27773535
chr14:95556677-95556678(-) m6A 3'UTR//intron       27773535//22608085
chr14:95556757-95556758(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556800-95556801(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556805-95556806(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556812-95556813(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556832-95556833(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556986-95556987(-) m6A CDS//exon       24981863//27773535
chr14:95560387-95560388(-) m6A CDS       27773535
chr14:95560420-95560421(-) m6A CDS       27773535
chr14:95560450-95560451(-) m6A CDS       27773535
chr14:95561748-95561749(-) m6A 3'UTR//intron       27773535
chr14:95561756-95561757(-) m6A 3'UTR//intron       27773535
chr14:95562141-95562142(-) m6A CDS//intron       22608085
chr14:95562284-95562285(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:95562349-95562350(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:95562409-95562410(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562467-95562468(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562574-95562575(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562655-95562656(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562912-95562913(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr14:95563020-95563021(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95563042-95563043(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95566153-95566154(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95566230-95566231(-) m6A CDS       27773535
chr14:95569847-95569848(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95569867-95569868(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95569935-95569936(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95570052-95570053(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95570148-95570149(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr14:95570277-95570278(-) m6A CDS//exon       24284625//24981863//22608085
chr14:95570314-95570315(-) m6A CDS//exon       24284625//24981863//22608085
chr14:95570448-95570449(-) m6A CDS//exon//intron       24284625//22608085
chr14:95572444-95572445(-) m6A CDS//exon       27773535
chr14:95572465-95572466(-) m6A CDS//exon       27773535
chr14:95574735-95574736(-) Tm CDS       -
chr14:95583004-95583005(-) m6A CDS//intron       24981863//27773535
chr14:95583967-95583968(-) m6A CDS//exon       24981863//27773535
chr14:95583991-95583992(-) m6A CDS//exon       24981863//27773535
chr14:95584024-95584025(-) m6A CDS//exon       24981863//27773535
chr14:95584069-95584070(-) m6A CDS//exon       24981863//27773535//22608085
chr14:95590535-95590536(-) m6A CDS//exon       24981863//27773535//22608085
chr14:95590614-95590615(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr14:95590744-95590745(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590771-95590772(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590862-95590863(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590906-95590907(-) m6A CDS       24284625//24981863//22608085
chr14:95590924-95590925(-) m6A CDS       24284625//24981863//22608085
chr14:95590966-95590967(-) m6A CDS       24284625//24981863//22608085
chr14:95590994-95590995(-) m6A CDS       24284625//24981863//22608085
chr14:95592919-95592920(-) m6A CDS       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DICER1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART3-3p
Interactor2: DICER1

Evidence Support:


Strong-Evidence Luciferase reporter assay
Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase

References:


[1]PMID 23342366 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes.
[2]PMID 22291592 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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