Basic Information:

  VIRBase ID:  

VHID00301847

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART3-3p:  MIMAT0003411          RAB13:  NR_073553     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART3-3p	RAB13
miRBase Accession/Entrez ID	MIMAT0003411	5872
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	GIG4

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RAB13	chr1:153954275-153954276(-) m6A 3'UTR//exon       24209618//25456834//24981863//27773535//22608085 chr1:153954299-153954300(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr1:153954528-153954529(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr1:153954539-153954540(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr1:153954571-153954572(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr1:153954599-153954600(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr1:153954615-153954616(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//27773536 chr1:153954717-153954718(-) m6A exon//intron       24209618//24981863//27773535//27371828//27773536 chr1:153954847-153954848(-) m6A exon//intron       24981863 chr1:153954897-153954898(-) m6A CDS//exon       24981863 chr1:153954942-153954943(-) m6A exon//intron       24981863 chr1:153955042-153955043(-) m6A CDS//exon       24981863 chr1:153955125-153955126(-) m6A exon//intron       24981863 chr1:153955164-153955165(-) m6A exon//intron       24981863 chr1:153955246-153955247(-) m6A CDS//exon       24981863//27773535 chr1:153955313-153955314(-) m6A exon//intron       24981863//27773535 chr1:153955396-153955397(-) m6A exon//intron       27773535 chr1:153955976-153955977(-) m6A exon//intron       27773535 chr1:153956028-153956029(-) m6A 5'UTR//CDS//exon       27773535 chr1:153956054-153956055(-) m6A 5'UTR//CDS//exon       27773535 chr1:153957207-153957208(-) m6A 5'UTR//CDS//exon       27773535 chr1:153958620-153958621(-) m6A CDS//exon       24981863 chr1:153958648-153958649(-) m6A CDS//exon       24981863 chr1:153958665-153958666(-) m6A CDS//exon       24981863 chr1:153958818-153958819(-) m6A 5'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RAB13	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART3-3p
Interactor2: RAB13

Evidence Support:

Strong-Evidence	Luciferase reporter assay//RT-PCR
Support Database	VIRmiRNA

References:

PMID	20413099	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Finally, we also cloned 3'UTRs of three putative EBV miRNA targets, namely TOMM22 (mitochondrial import receptor subunit TOM22 homolog), IPO7 (importin 7), and RAB13 (RAB13, member RAS oncogene family) into dual-luciferase vectors. Potential binding sites for EBV miRNAs were predicted using RNAhybrid(Rehmsmeier et al., 2004).