Detail Information

Basic Information:


  VIRBase ID:  

VHID00301661

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART3-3p:           MICB:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART3-3p MICB
miRBase
Accession/Entrez ID		 MIMAT0003411 4277
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - PERB11.2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MICB
chr6:31471991(+) A-I      intronic
chr6:31470045(+) A-I      intronic
chr6:31470010(+) A-I      intronic
chr6:31472130(+) A-I      intronic
chr6:31469983(+) A-I      intronic
chr6:31470008(+) A-I      intronic
chr6:31470005(+) A-I      intronic
chr6:31472098(+) A-I      intronic
chr6:31469992(+) A-I      intronic
chr6:31472092(+) A-I      intronic
chr6:31469911(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MICB
chr6:31473469-31473470(+) m6A CDS       -
chr6:31473532-31473533(+) m6A CDS       25456834
chr6:31473563-31473564(+) m6A CDS       25456834
chr6:31473570-31473571(+) m6A CDS       25456834
chr6:31473578-31473579(+) m6A CDS       25456834
chr6:31473585-31473586(+) m6A CDS       24284625//25456834//24981863
chr6:31473606-31473607(+) m6A CDS       24284625//25456834//24981863
chr6:31473617-31473618(+) m6A CDS       24284625//25456834//24981863
chr6:31473636-31473637(+) m6A CDS       24284625//25456834//24981863
chr6:31473715-31473716(+) m6A exon//intron       24284625//25456834//24981863
chr6:31478073-31478074(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MICB
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART3-3p
Interactor2: MICB

Evidence Support:


Strong-Evidence Luciferase reporter assay
Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase

References:


[1]PMID 23342366 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis (PUMA), DICER1, and BIM [96,97,98] (Table 2).
[2]PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description Of the 12 PAR-CLIP-identified target 3'UTRs tested against EBV miRNAs, 11 3'UTRs (BACH1, CLEC2D, CLIP1, DAZAP2, KDM4B, LY75, OTUD1, PDE7A, PELI1, SP100, ZNF451) resulted in luciferase inhibition following ectopic viral miRNA expression (Figure S3).

Starting a new search, please wait ...