Basic Information:

  VIRBase ID:  

VHID00301602

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART3-3p:  MIMAT0003411          KPNA4:  NM_002268     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART3-3p	KPNA4
miRBase Accession/Entrez ID	MIMAT0003411	3840
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	IPOA3//QIP1//SRP3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KPNA4	chr3:160220339(-) A-I      intronic chr3:160220336(-) A-I      intronic chr3:160242407(-) A-I      intronic chr3:160264243(-) A-I      intronic chr3:160242378(-) A-I      intronic chr3:160264176(-) A-I      intronic chr3:160264162(-) A-I      intronic chr3:160264143(-) A-I      intronic chr3:160264061(-) A-I      intronic chr3:160264058(-) A-I      intronic chr3:160242356(-) A-I      intronic chr3:160221762(-) A-I      intronic chr3:160221760(-) A-I      intronic chr3:160221715(-) A-I      intronic chr3:160261873(-) A-I      intronic chr3:160220251(-) A-I      intronic chr3:160220261(-) A-I      intronic chr3:160220287(-) A-I      intronic chr3:160220335(-) A-I      intronic chr3:160220401(-) A-I      intronic chr3:160220636(-) A-I      intronic chr3:160220655(-) A-I      intronic chr3:160220750(-) A-I      intronic chr3:160220823(-) A-I      intronic chr3:160220893(-) A-I      intronic chr3:160221748(-) A-I      intronic chr3:160225095(-) A-I      intronic chr3:160225124(-) A-I      intronic chr3:160225188(-) A-I      intronic chr3:160229091(-) A-I      intronic chr3:160230485(-) A-I      intronic chr3:160230508(-) A-I      intronic chr3:160230568(-) A-I      intronic chr3:160230571(-) A-I      intronic chr3:160231085(-) A-I      intronic chr3:160231106(-) A-I      intronic chr3:160233871(-) A-I      intronic chr3:160233913(-) A-I      intronic chr3:160233998(-) A-I      intronic chr3:160234022(-) A-I      intronic chr3:160234396(-) A-I      intronic chr3:160234498(-) A-I      intronic chr3:160234503(-) A-I      intronic chr3:160236567(-) A-I      intronic chr3:160239130(-) A-I      intronic chr3:160239152(-) A-I      intronic chr3:160239369(-) A-I      intronic chr3:160239387(-) A-I      intronic chr3:160239388(-) A-I      intronic chr3:160241067(-) A-I      intronic chr3:160242128(-) A-I      intronic chr3:160242242(-) A-I      intronic chr3:160242254(-) A-I      intronic chr3:160246938(-) A-I      intronic chr3:160246942(-) A-I      intronic chr3:160246995(-) A-I      intronic chr3:160250872(-) A-I      intronic chr3:160250879(-) A-I      intronic chr3:160250884(-) A-I      intronic chr3:160250900(-) A-I      intronic chr3:160252273(-) A-I      intronic chr3:160261265(-) A-I      intronic chr3:160261290(-) A-I      intronic chr3:160261377(-) A-I      intronic chr3:160261883(-) A-I      intronic chr3:160264134(-) A-I      intronic chr3:160264259(-) A-I      intronic chr3:160214042(-) A-I      3'UTR chr3:160214007(-) A-I      3'UTR chr3:160213994(-) A-I      3'UTR chr3:160214013(-) A-I      3'UTR chr3:160213910(-) A-I      3'UTR chr3:160213993(-) A-I      3'UTR chr3:160213884(-) A-I      3'UTR chr3:160213896(-) A-I      3'UTR chr3:160238321(-) A-I      intronic chr3:160234474(-) A-I      intronic chr3:160220341(-) A-I      intronic chr3:160230454(-) A-I      intronic chr3:160239334(-) A-I      intronic chr3:160261892(-) A-I      intronic chr3:160221699(-) A-I      intronic chr3:160252739(-) A-I      intronic chr3:160252251(-) A-I      intronic chr3:160231252(-) A-I      intronic chr3:160225030(-) A-I      intronic chr3:160234323(-) A-I      intronic chr3:160246918(-) A-I      intronic chr3:160220438(-) A-I      intronic chr3:160220897(-) A-I      intronic chr3:160241038(-) A-I      intronic chr3:160252782(-) A-I      intronic chr3:160220250(-) A-I      intronic chr3:160252340(-) A-I      intronic chr3:160221652(-) A-I      intronic chr3:160215034(-) A-I      3'UTR chr3:160214000(-) A-I      3'UTR chr3:160214984(-) A-I      3'UTR chr3:160220327(-) A-I      intronic chr3:160231208(-) A-I      intronic chr3:160246881(-) A-I      intronic chr3:160220791(-) A-I      intronic chr3:160231195(-) A-I      intronic chr3:160234365(-) A-I      intronic chr3:160242305(-) A-I      intronic chr3:160233872(-) A-I      intronic chr3:160220813(-) A-I      intronic chr3:160220415(-) A-I      intronic chr3:160236573(-) A-I      intronic chr3:160221747(-) A-I      intronic chr3:160233912(-) A-I      intronic chr3:160221653(-) A-I      intronic chr3:160261935(-) A-I      intronic chr3:160238108(-) A-I      intronic chr3:160225121(-) A-I      intronic chr3:160221716(-) A-I      intronic chr3:160238188(-) A-I      intronic chr3:160264223(-) A-I      intronic chr3:160252384(-) A-I      intronic chr3:160220654(-) A-I      intronic chr3:160241089(-) A-I      intronic chr3:160228678(-) A-I      intronic chr3:160220363(-) A-I      intronic chr3:160252358(-) A-I      intronic chr3:160241556(-) A-I      intronic chr3:160220227(-) A-I      intronic chr3:160246982(-) A-I      intronic chr3:160220852(-) A-I      intronic chr3:160221705(-) A-I      intronic chr3:160220642(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KPNA4	chr3:160219827(-) A-I exon 3'UTR    22327324 chr3:160219837(-) A-I exon 3'UTR    22327324 chr3:160214000(-) A-G exon 3'UTR    22484847 chr3:160220227(-) A-G intron -    22484847 chr3:160220297(-) A-G intron -    22484847 chr3:160220326(-) A-G intron -    22484847 chr3:160220341(-) A-G intron -    22484847 chr3:160220438(-) A-G intron -    22484847 chr3:160220654(-) A-G intron -    22484847 chr3:160220852(-) A-G intron -    22484847 chr3:160220897(-) A-G intron -    22484847 chr3:160221764(-) A-G intron -    22484847 chr3:160228678(-) A-G intron -    22484847 chr3:160231192(-) A-G intron -    22484847 chr3:160231195(-) A-G intron -    22484847 chr3:160231208(-) A-G intron -    22484847 chr3:160233872(-) A-G intron -    22484847 chr3:160234438(-) A-G intron -    22484847 chr3:160236573(-) A-G intron -    22484847 chr3:160239334(-) A-G intron -    22484847 chr3:160239339(-) A-G intron -    22484847 chr3:160241038(-) A-G intron -    22484847 chr3:160241093(-) A-G intron -    22484847 chr3:160242391(-) A-G intron -    22484847 chr3:160252358(-) A-G intron -    22484847 chr3:160252384(-) A-G intron -    22484847 chr3:160261832(-) T-C intron -    22484847 chr3:160261892(-) A-G intron -    22484847 chr3:160261935(-) A-G intron -    22484847 chr3:160264088(-) A-G intron -    22484847 chr3:160273734(-) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KPNA4	chr3:160214238-160214239(-) m6A 3'UTR       27773535 chr3:160214298-160214299(-) m6A 3'UTR       27773535 chr3:160214447-160214448(-) m6A 3'UTR       27773535 chr3:160214553-160214554(-) m6A 3'UTR       27773535 chr3:160219173-160219174(-) m6A 3'UTR       24981863//22608085 chr3:160219189-160219190(-) m6A 3'UTR       24981863//22608085 chr3:160219195-160219196(-) m6A 3'UTR       24981863//22608085 chr3:160219564-160219565(-) m6A 3'UTR       24981863//27773535 chr3:160219641-160219642(-) m6A 3'UTR       24981863//27773535 chr3:160219778-160219779(-) Y 3'UTR       26075521 chr3:160233300-160233301(-) m6A CDS       - chr3:160233316-160233317(-) m6A CDS       - chr3:160233328-160233329(-) m6A CDS       - chr3:160239624-160239625(-) m6A CDS       - chr3:160239644-160239645(-) m6A CDS       - chr3:160253623-160253624(-) m6A CDS       22575960 chr3:160253670-160253671(-) m6A CDS       24981863//22575960 chr3:160254616-160254617(-) m6A CDS       24209618//24981863 chr3:160282405-160282406(-) m6A exon//intron       24209618 chr3:160283020-160283021(-) m6A CDS//exon       24209618//24981863//27371828//27773536//22575960 chr3:160283047-160283048(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536//22575960 chr3:160283052-160283053(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536//22575960 chr3:160283062-160283063(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	KPNA4	Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART3-3p
Interactor2: KPNA4

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.