Detail Information

Basic Information:


  VIRBase ID:  

VHID00301563

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART3-3p:           IL16:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART3-3p IL16
miRBase
Accession/Entrez ID		 MIMAT0003411 3603
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - LCF//NIL16//prIL-16//PRIL16

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL16
chr15:81529048(+) A-I      intronic
chr15:81497510(+) A-I      intronic
chr15:81500737(+) A-I      intronic
chr15:81571185(+) A-I      NonSyn:Glu->Gly
chr15:81512605(+) A-I      intronic
chr15:81500945(+) A-I      intronic
chr15:81492886(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IL16
chr15:81571185(+) A-I exon CDS    19478186

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL16
chr15:81585196-81585197(+) m6A 3'UTR//CDS       -
chr15:81585215-81585216(+) m6A 3'UTR//CDS       -
chr15:81585334-81585335(+) m6A 3'UTR//CDS       -
chr15:81589308-81589309(+) m6A 3'UTR//5'UTR//CDS       27371828
chr15:81589351-81589352(+) m6A 3'UTR//5'UTR//CDS//exon       27371828
chr15:81589370-81589371(+) m6A 3'UTR//5'UTR//CDS//exon       27371828
chr15:81591651-81591652(+) m6A CDS//intron       27371828
chr15:81591728-81591729(+) m6A 3'UTR//5'UTR//CDS//intron       27371828
chr15:81591742-81591743(+) m6A 3'UTR//5'UTR//CDS//intron       -
chr15:81591774-81591775(+) m6A 3'UTR//CDS//intron       -
chr15:81591801-81591802(+) m6A 3'UTR//CDS//intron       -
chr15:81591834-81591835(+) m6A 3'UTR//CDS//intron       26404942
chr15:81591861-81591862(+) m6A 3'UTR//CDS//intron       26404942
chr15:81591914-81591915(+) m6A 3'UTR//CDS//exon       26404942//27371828
chr15:81591935-81591936(+) m6A 3'UTR//CDS//exon       26404942//27371828
chr15:81591951-81591952(+) m6A 3'UTR//CDS//exon       26404942//27371828
chr15:81591990-81591991(+) m6A 3'UTR//CDS//exon       26404942//27371828
chr15:81592080-81592081(+) m6A 3'UTR//CDS//exon       -
chr15:81592208-81592209(+) m6A 3'UTR//CDS//exon       -
chr15:81592249-81592250(+) m6A 3'UTR//CDS//exon       25456834
chr15:81592285-81592286(+) m6A 3'UTR//CDS//exon       25456834
chr15:81592321-81592322(+) m6A 3'UTR//CDS//exon       25456834
chr15:81592413-81592414(+) m6A 3'UTR//CDS       -
chr15:81592463-81592464(+) m6A 3'UTR//CDS       -
chr15:81592482-81592483(+) m6A 3'UTR//CDS       -
chr15:81592616-81592617(+) m6A 3'UTR//CDS       -
chr15:81592624-81592625(+) m6A 3'UTR//CDS       -
chr15:81598201-81598202(+) m6A exon//intron       -
chr15:81598206-81598207(+) m6A exon//intron       -
chr15:81598290-81598291(+) m6A 3'UTR//CDS//exon       -
chr15:81598344-81598345(+) m6A 3'UTR//CDS//exon       -
chr15:81601044-81601045(+) m6A 3'UTR//CDS       22575960
chr15:81601069-81601070(+) m6A 3'UTR//CDS       26404942//22575960
chr15:81601115-81601116(+) m6A 3'UTR//CDS       26404942//22575960
chr15:81601131-81601132(+) m6A 3'UTR//CDS       26404942//22575960
chr15:81601144-81601145(+) m6A 3'UTR       26404942//22575960
chr15:81601282-81601283(+) m6A 3'UTR       -
chr15:81601363-81601364(+) m6A 3'UTR       -
chr15:81601499-81601500(+) m6A 3'UTR       -
chr15:81601615-81601616(+) m6A 3'UTR       25456834//27371828
chr15:81601665-81601666(+) m6A 3'UTR       -
chr15:81601939-81601940(+) m6A 3'UTR       -
chr15:81602006-81602007(+) m6A 3'UTR       -
chr15:81602045-81602046(+) m6A 3'UTR       -
chr15:81602066-81602067(+) m6A 3'UTR       -
chr15:81602296-81602297(+) m6A 3'UTR       -
chr15:81602407-81602408(+) m6A 3'UTR       -
chr15:81602520-81602521(+) m6A 3'UTR       -
chr15:81602531-81602532(+) m6A 3'UTR       -
chr15:81602542-81602543(+) m6A 3'UTR       -
chr15:81602548-81602549(+) m6A 3'UTR       -
chr15:81602824-81602825(+) m6A 3'UTR       -
chr15:81602836-81602837(+) m6A 3'UTR       -
chr15:81602842-81602843(+) m6A 3'UTR       -
chr15:81602874-81602875(+) m6A 3'UTR       -
chr15:81602885-81602886(+) m6A 3'UTR       -
chr15:81602898-81602899(+) m6A 3'UTR       -
chr15:81603006-81603007(+) m6A 3'UTR       -
chr15:81603108-81603109(+) m6A 3'UTR       -
chr15:81603122-81603123(+) m6A 3'UTR       -
chr15:81603167-81603168(+) m6A 3'UTR       -
chr15:81603179-81603180(+) m6A 3'UTR       -
chr15:81603202-81603203(+) m6A 3'UTR       -
chr15:81603313-81603314(+) m6A 3'UTR       25456834//27371828
chr15:81603416-81603417(+) m6A 3'UTR       -
chr15:81603528-81603529(+) m6A 3'UTR       -
chr15:81603721-81603722(+) m6A 3'UTR       -
chr15:81603787-81603788(+) m6A 3'UTR       25456834
chr15:81603965-81603966(+) m6A 3'UTR       -
chr15:81604609-81604610(+) m6A 3'UTR       27371828
chr15:81604739-81604740(+) m6A 3'UTR       25456834//27773536
chr15:81604745-81604746(+) m6A 3'UTR       25456834//27773536
chr15:81604838-81604839(+) m6A 3'UTR       25456834
chr15:81604875-81604876(+) m6A 3'UTR       25456834
chr15:81604907-81604908(+) m6A 3'UTR       25456834
chr15:81604937-81604938(+) m6A 3'UTR       25456834
chr15:81604944-81604945(+) m6A 3'UTR       25456834
chr15:81605149-81605150(+) m6A 3'UTR       -
chr15:81605379-81605380(+) m6A 3'UTR       -
chr15:81605499-81605500(+) m6A 3'UTR       -
chr15:81605640-81605641(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate IL16
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART3-3p
Interactor2: IL16

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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