Basic Information:

  VIRBase ID:  

VHID00301554

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART3-3p:  MIMAT0003411          IFNAR2:  NM_001289126     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART3-3p	IFNAR2
miRBase Accession/Entrez ID	MIMAT0003411	3455
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	IFN-alpha-REC//IFN-R//IFNABR//IFNARB//IMD45

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IFNAR2	chr21:34615537(+) A-I      intronic chr21:34615553(+) A-I      intronic chr21:34634870(+) A-I      NonSyn:Gln->Arg chr21:34634993(+) A-I      NonSyn:Lys->Arg chr21:34634881(+) A-I      NonSyn:Lys->Glu chr21:34637281(+) A-I      3'UTR chr21:34637136(+) A-I      3'UTR chr21:34637065(+) A-I      3'UTR chr21:34634980(+) A-I      NonSyn:Ser->Gly chr21:34604212(+) A-I      intronic chr21:34637181(+) A-I      3'UTR chr21:34615235(+) A-I      intronic chr21:34615220(+) A-I      intronic chr21:34634619(+) A-I      intronic chr21:34634610(+) A-I      intronic chr21:34634589(+) A-I      intronic chr21:34634580(+) A-I      intronic chr21:34634469(+) A-I      intronic chr21:34634133(+) A-I      intronic chr21:34634038(+) A-I      intronic chr21:34624313(+) A-I      intronic chr21:34624238(+) A-I      intronic chr21:34624217(+) A-I      intronic chr21:34609680(+) A-I      intronic chr21:34615173(+) A-I      intronic chr21:34614884(+) A-I      intronic chr21:34608110(+) A-I      intronic chr21:34615193(+) A-I      intronic chr21:34615412(+) A-I      intronic chr21:34615549(+) A-I      intronic chr21:34634856(+) A-I      intronic chr21:34624295(+) A-I      intronic chr21:34622969(+) A-I      intronic chr21:34622982(+) A-I      intronic chr21:34623000(+) A-I      intronic chr21:34624154(+) A-I      intronic chr21:34624163(+) A-I      intronic chr21:34624211(+) A-I      intronic chr21:34614959(+) A-I      intronic chr21:34614923(+) A-I      intronic chr21:34614958(+) A-I      intronic chr21:34608116(+) A-I      intronic chr21:34637207(+) A-I      3'UTR chr21:34637142(+) A-I      3'UTR chr21:34636426(+) A-I      3'UTR chr21:34636386(+) A-I      3'UTR chr21:34637022(+) A-I      3'UTR chr21:34637061(+) A-I      3'UTR chr21:34637165(+) A-I      3'UTR chr21:34637087(+) A-I      3'UTR chr21:34637116(+) A-I      3'UTR chr21:34637278(+) A-I      3'UTR chr21:34637098(+) A-I      3'UTR chr21:34636393(+) A-I      3'UTR chr21:34637241(+) A-I      3'UTR chr21:34637095(+) A-I      3'UTR chr21:34637137(+) A-I      3'UTR chr21:34636399(+) A-I      3'UTR chr21:34637205(+) A-I      3'UTR chr21:34637115(+) A-I      3'UTR chr21:34636239(+) A-I      3'UTR chr21:34637110(+) A-I      3'UTR chr21:34637245(+) A-I      3'UTR chr21:34636349(+) A-I      3'UTR chr21:34636344(+) A-I      3'UTR chr21:34636351(+) A-I      3'UTR chr21:34637108(+) A-I      3'UTR chr21:34636215(+) A-I      3'UTR chr21:34637266(+) A-I      3'UTR chr21:34636328(+) A-I      3'UTR chr21:34636319(+) A-I      3'UTR chr21:34636353(+) A-I      3'UTR chr21:34637198(+) A-I      3'UTR chr21:34637251(+) A-I      3'UTR chr21:34636316(+) A-I      3'UTR chr21:34637192(+) A-I      3'UTR chr21:34637150(+) A-I      3'UTR chr21:34636305(+) A-I      3'UTR chr21:34636242(+) A-I      3'UTR chr21:34637224(+) A-I      3'UTR chr21:34634968(+) A-I      NonSyn:Ser->Gly chr21:34637185(+) A-I      3'UTR chr21:34636425(+) A-I      3'UTR chr21:34636364(+) A-I      3'UTR chr21:34636179(+) A-I      3'UTR chr21:34615194(+) A-I      intronic chr21:34615353(+) A-I      intronic chr21:34634439(+) A-I      intronic chr21:34633468(+) A-I      intronic chr21:34633965(+) A-I      intronic chr21:34604186(+) A-I      intronic chr21:34615367(+) A-I      intronic chr21:34604250(+) A-I      intronic chr21:34621518(+) A-I      intronic chr21:34633981(+) A-I      intronic chr21:34634050(+) A-I      intronic chr21:34615018(+) A-I      intronic chr21:34620550(+) A-I      intronic chr21:34614850(+) A-I      intronic chr21:34614782(+) A-I      intronic chr21:34621581(+) A-I      intronic chr21:34604227(+) A-I      intronic chr21:34615233(+) A-I      intronic chr21:34614891(+) A-I      intronic chr21:34615631(+) A-I      intronic chr21:34612870(+) A-I      intronic chr21:34615356(+) A-I      intronic chr21:34633542(+) A-I      intronic chr21:34612931(+) A-I      intronic chr21:34613077(+) A-I      intronic chr21:34633604(+) A-I      intronic chr21:34604224(+) A-I      intronic chr21:34633467(+) A-I      intronic chr21:34622861(+) A-I      intronic chr21:34613040(+) A-I      intronic chr21:34615198(+) A-I      intronic chr21:34634447(+) A-I      intronic chr21:34634486(+) A-I      intronic chr21:34634438(+) A-I      intronic chr21:34630590(+) A-I      intronic chr21:34634443(+) A-I      intronic chr21:34634514(+) A-I      intronic chr21:34633483(+) A-I      intronic chr21:34637140(+) A-I      3'UTR chr21:34637216(+) A-I      3'UTR chr21:34636385(+) A-I      3'UTR chr21:34636204(+) A-I      3'UTR chr21:34636260(+) A-I      3'UTR chr21:34636253(+) A-I      3'UTR chr21:34636259(+) A-I      3'UTR chr21:34637079(+) A-I      3'UTR chr21:34637145(+) A-I      3'UTR chr21:34636203(+) A-I      3'UTR chr21:34637159(+) A-I      3'UTR chr21:34636293(+) A-I      3'UTR chr21:34637246(+) A-I      3'UTR chr21:34637144(+) A-I      3'UTR chr21:34637208(+) A-I      3'UTR chr21:34636181(+) A-I      3'UTR chr21:34637084(+) A-I      3'UTR chr21:34637093(+) A-I      3'UTR chr21:34637237(+) A-I      3'UTR chr21:34636183(+) A-I      3'UTR chr21:34637149(+) A-I      3'UTR chr21:34637146(+) A-I      3'UTR chr21:34633947(+) A-I      intronic chr21:34608044(+) A-I      intronic chr21:34604281(+) A-I      intronic chr21:34609693(+) A-I      intronic chr21:34612862(+) A-I      intronic chr21:34622898(+) A-I      intronic chr21:34612914(+) A-I      intronic chr21:34613000(+) A-I      intronic chr21:34615376(+) A-I      intronic chr21:34614783(+) A-I      intronic chr21:34615408(+) A-I      intronic chr21:34623124(+) A-I      intronic chr21:34615114(+) A-I      intronic chr21:34604147(+) A-I      intronic chr21:34614888(+) A-I      intronic chr21:34634414(+) A-I      intronic chr21:34615303(+) A-I      intronic chr21:34615163(+) A-I      intronic chr21:34604071(+) A-I      intronic chr21:34612871(+) A-I      intronic chr21:34615514(+) A-I      intronic chr21:34615428(+) A-I      intronic chr21:34614881(+) A-I      intronic chr21:34612988(+) A-I      intronic chr21:34633435(+) A-I      intronic chr21:34634395(+) A-I      intronic chr21:34612990(+) A-I      intronic chr21:34609729(+) A-I      intronic chr21:34612929(+) A-I      intronic chr21:34615572(+) A-I      intronic chr21:34623033(+) A-I      intronic chr21:34633422(+) A-I      intronic chr21:34613101(+) A-I      intronic chr21:34609719(+) A-I      intronic chr21:34633999(+) A-I      intronic chr21:34633551(+) A-I      intronic chr21:34615284(+) A-I      intronic chr21:34613014(+) A-I      intronic chr21:34634122(+) A-I      intronic chr21:34615283(+) A-I      intronic chr21:34604254(+) A-I      intronic chr21:34621528(+) A-I      intronic chr21:34615662(+) A-I      intronic chr21:34623118(+) A-I      intronic chr21:34612973(+) A-I      intronic chr21:34615016(+) A-I      intronic chr21:34621394(+) A-I      intronic chr21:34633411(+) A-I      intronic chr21:34634034(+) A-I      intronic chr21:34604072(+) A-I      intronic chr21:34615021(+) A-I      intronic chr21:34615126(+) A-I      intronic chr21:34615617(+) A-I      intronic chr21:34623087(+) A-I      intronic chr21:34634042(+) A-I      intronic chr21:34612985(+) A-I      intronic chr21:34621569(+) A-I      intronic chr21:34614917(+) A-I      intronic chr21:34615563(+) A-I      intronic chr21:34634952(+) A-I      Syn:Lys->Lys chr21:34634882(+) A-I      NonSyn:Lys->Arg

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IFNAR2	chr21:34621070(+) A-I exon CDS    15342557 chr21:34636203(+) A-I exon 3'UTR    15258596 chr21:34636234(+) A-I exon 3'UTR    15342557   //15258596 chr21:34636253(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34636259(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34636260(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34636347(+) A-I exon 3'UTR    15258596 chr21:34636361(+) A-I exon 3'UTR    15342557   //15258596 chr21:34636384(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34604071(+) A-I intron -    21960545   //22327324 chr21:34612928(+) A-I intron -    22327324 chr21:34612933(+) A-I intron -    22327324 chr21:34612973(+) A-I intron -    22327324 chr21:34612990(+) A-I intron -    22327324 chr21:34613040(+) A-I intron -    22327324 chr21:34636204(+) A-I intron -    22327324 chr21:34636293(+) A-I intron -    22327324 chr21:34636303(+) A-I intron -    22327324 chr21:34636385(+) A-I intron -    22327324 chr21:34604072(+) A-I intron -    21960545 chr21:34604127(+) A-I intron -    21960545 chr21:34604181(+) A-I intron -    21960545 chr21:34604250(+) A-I intron -    21960545 chr21:34612929(+) A-I intron -    21960545 chr21:34631036(+) A-I intron -    21960545 chr21:34604071(+) A-G intron -    22484847 chr21:34604072(+) A-G intron -    22484847 chr21:34604188(+) A-G intron -    22484847 chr21:34604224(+) A-G intron -    22484847 chr21:34604227(+) A-G intron -    22484847 chr21:34604250(+) A-G intron -    22484847 chr21:34604281(+) A-G intron -    22484847 chr21:34604313(+) A-G intron -    22484847 chr21:34608044(+) A-G intron -    22484847 chr21:34609760(+) A-G intron -    22484847 chr21:34609765(+) A-G intron -    22484847 chr21:34612928(+) A-G intron -    22484847 chr21:34612929(+) A-G intron -    22484847 chr21:34612931(+) A-G intron -    22484847 chr21:34612933(+) A-G intron -    22484847 chr21:34612973(+) A-G intron -    22484847 chr21:34612988(+) A-G intron -    22484847 chr21:34612990(+) A-G intron -    22484847 chr21:34613040(+) A-G intron -    22484847 chr21:34613119(+) C-A intron -    22484847 chr21:34615578(+) A-G intron -    22484847 chr21:34615650(+) A-G intron -    22484847 chr21:34620550(+) A-G intron -    22484847 chr21:34633399(+) T-C intron -    22484847 chr21:34633965(+) A-G intron -    22484847 chr21:34634074(+) A-G intron -    22484847 chr21:34634122(+) A-G intron -    22484847 chr21:34634176(+) A-G intron -    22484847 chr21:34634395(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFNAR2	chr21:34635049-34635050(+) m6A 3'UTR//intron       - chr21:34635067-34635068(+) m6A 3'UTR//intron       - chr21:34635250-34635251(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635279-34635280(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635338-34635339(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635404-34635405(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635423-34635424(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635467-34635468(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635485-34635486(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635533-34635534(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635539-34635540(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635572-34635573(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635659-34635660(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635685-34635686(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635812-34635813(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34635824-34635825(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34635830-34635831(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34635919-34635920(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr21:34635975-34635976(+) m6A 3'UTR       24981863//22608085 chr21:34636350-34636351(+) m6A 3'UTR       24209618 chr21:34636385-34636386(+) m6A 3'UTR       24209618 chr21:34636610-34636611(+) m6A 3'UTR       24209618//24981863//27773535 chr21:34636729-34636730(+) m6A 3'UTR       24209618//24981863 chr21:34636770-34636771(+) m6A 3'UTR       24981863//27773535 chr21:34636795-34636796(+) m6A 3'UTR       24981863//27773535 chr21:34636835-34636836(+) m6A 3'UTR       24981863//27773535 chr21:34636888-34636889(+) m6A 3'UTR       24209618//24981863//27773535 chr21:34637062-34637063(+) m6A 3'UTR       - chr21:34637094-34637095(+) m6A 3'UTR       - chr21:34637131-34637132(+) m6A 3'UTR       - chr21:34637352-34637353(+) m6A 3'UTR       24284625 chr21:34637358-34637359(+) m6A 3'UTR       24284625 chr21:34637458-34637459(+) m6A 3'UTR       24981863//22608085 chr21:34637484-34637485(+) m6A 3'UTR       24981863//22608085 chr21:34637519-34637520(+) m6A 3'UTR       24981863//22608085 chr21:34637578-34637579(+) m6A 3'UTR       24981863//22608085 chr21:34637624-34637625(+) m6A 3'UTR       24981863 chr21:34637656-34637657(+) m6A 3'UTR       24981863//26404942 chr21:34637686-34637687(+) m6A 3'UTR       24981863//26404942 chr21:34637741-34637742(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IFNAR2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART3-3p
Interactor2: IFNAR2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

[1]PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

[2]PMID	22291592	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).