Basic Information:

  VIRBase ID:  

VHID00301361

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART3-3p:  MIMAT0003411          DAPK1:  NM_004938     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART3-3p	DAPK1
miRBase Accession/Entrez ID	MIMAT0003411	1612
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DAPK//ROCO3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DAPK1	chr9:90143666(+) A-I      intronic chr9:90155380(+) A-I      intronic chr9:90155204(+) A-I      intronic chr9:90189620(+) A-I      intronic chr9:90176326(+) A-I      intronic chr9:90176291(+) A-I      intronic chr9:90176281(+) A-I      intronic chr9:90176225(+) A-I      intronic chr9:90176192(+) A-I      intronic chr9:90175824(+) A-I      intronic chr9:90175761(+) A-I      intronic chr9:90175730(+) A-I      intronic chr9:90175726(+) A-I      intronic chr9:90175715(+) A-I      intronic chr9:90175714(+) A-I      intronic chr9:90296118(+) A-I      intronic chr9:90315513(+) A-I      intronic chr9:90315506(+) A-I      intronic chr9:90192592(+) A-I      intronic chr9:90155128(+) A-I      intronic chr9:90192557(+) A-I      intronic chr9:90140945(+) A-I      intronic chr9:90138462(+) A-I      intronic chr9:90118314(+) A-I      intronic chr9:90155126(+) A-I      intronic chr9:90143676(+) A-I      intronic chr9:90143274(+) A-I      intronic chr9:90140986(+) A-I      intronic chr9:90189716(+) A-I      intronic chr9:90189690(+) A-I      intronic chr9:90172700(+) A-I      intronic chr9:90143294(+) A-I      intronic chr9:90175710(+) A-I      intronic chr9:90175693(+) A-I      intronic chr9:90175681(+) A-I      intronic chr9:90175680(+) A-I      intronic chr9:90175606(+) A-I      intronic chr9:90315518(+) A-I      intronic chr9:90296125(+) A-I      intronic chr9:90296120(+) A-I      intronic chr9:90296073(+) A-I      intronic chr9:90252143(+) A-I      intronic chr9:90252138(+) A-I      intronic chr9:90252109(+) A-I      intronic chr9:90252102(+) A-I      intronic chr9:90237562(+) A-I      intronic chr9:90237557(+) A-I      intronic chr9:90215409(+) A-I      intronic chr9:90199854(+) A-I      intronic chr9:90199835(+) A-I      intronic chr9:90199789(+) A-I      intronic chr9:90199709(+) A-I      intronic chr9:90199647(+) A-I      intronic chr9:90199622(+) A-I      intronic chr9:90226425(+) A-I      intronic chr9:90155358(+) A-I      intronic chr9:90120653(+) A-I      intronic chr9:90197569(+) A-I      intronic chr9:90175602(+) A-I      intronic chr9:90175173(+) A-I      intronic chr9:90175045(+) A-I      intronic chr9:90175023(+) A-I      intronic chr9:90175005(+) A-I      intronic chr9:90172745(+) A-I      intronic chr9:90172709(+) A-I      intronic chr9:90172702(+) A-I      intronic chr9:90192584(+) A-I      intronic chr9:90172641(+) A-I      intronic chr9:90192654(+) A-I      intronic chr9:90192435(+) A-I      intronic chr9:90191708(+) A-I      intronic chr9:90140379(+) A-I      intronic chr9:90140405(+) A-I      intronic chr9:90170536(+) A-I      intronic chr9:90167640(+) A-I      intronic chr9:90167571(+) A-I      intronic chr9:90167546(+) A-I      intronic chr9:90167530(+) A-I      intronic chr9:90162056(+) A-I      intronic chr9:90161951(+) A-I      intronic chr9:90140416(+) A-I      intronic chr9:90140417(+) A-I      intronic chr9:90161941(+) A-I      intronic chr9:90161957(+) A-I      intronic chr9:90160480(+) A-I      intronic chr9:90156385(+) A-I      intronic chr9:90156384(+) A-I      intronic chr9:90191653(+) A-I      intronic chr9:90191638(+) A-I      intronic chr9:90191598(+) A-I      intronic chr9:90190014(+) A-I      intronic chr9:90189904(+) A-I      intronic chr9:90189877(+) A-I      intronic chr9:90156313(+) A-I      intronic chr9:90156312(+) A-I      intronic chr9:90156287(+) A-I      intronic chr9:90156256(+) A-I      intronic chr9:90156229(+) A-I      intronic chr9:90155386(+) A-I      intronic chr9:90116180(+) A-I      intronic chr9:90172771(+) A-I      intronic chr9:90199691(+) A-I      intronic chr9:90315467(+) A-I      intronic chr9:90168511(+) A-I      intronic chr9:90241075(+) A-I      intronic chr9:90162021(+) A-I      intronic chr9:90161992(+) A-I      intronic chr9:90315445(+) A-I      intronic chr9:90315613(+) A-I      intronic chr9:90143202(+) A-I      intronic chr9:90175111(+) A-I      intronic chr9:90161991(+) A-I      intronic chr9:90320236(+) A-I      intronic chr9:90175047(+) A-I      intronic chr9:90252259(+) A-I      intronic chr9:90199725(+) A-I      intronic chr9:90172587(+) A-I      intronic chr9:90237705(+) A-I      intronic chr9:90160602(+) A-I      intronic chr9:90116252(+) A-I      intronic chr9:90143232(+) A-I      intronic chr9:90315483(+) A-I      intronic chr9:90191682(+) A-I      intronic chr9:90315514(+) A-I      intronic chr9:90143233(+) A-I      intronic chr9:90156307(+) A-I      intronic chr9:90116248(+) A-I      intronic chr9:90116232(+) A-I      intronic chr9:90295272(+) A-I      intronic chr9:90116372(+) A-I      intronic chr9:90160520(+) A-I      intronic chr9:90317693(+) A-I      intronic chr9:90191647(+) A-I      intronic chr9:90317683(+) A-I      intronic chr9:90191537(+) A-I      intronic chr9:90156397(+) A-I      intronic chr9:90152002(+) A-I      intronic chr9:90152103(+) A-I      intronic chr9:90138403(+) A-I      intronic chr9:90116207(+) A-I      intronic chr9:90156343(+) A-I      intronic chr9:90172735(+) A-I      intronic chr9:90156344(+) A-I      intronic chr9:90312613(+) A-I      intronic chr9:90192506(+) A-I      intronic chr9:90120803(+) A-I      intronic chr9:90317746(+) A-I      intronic chr9:90176284(+) A-I      intronic chr9:90155270(+) A-I      intronic chr9:90176256(+) A-I      intronic chr9:90237650(+) A-I      intronic chr9:90167531(+) A-I      intronic chr9:90191572(+) A-I      intronic chr9:90156360(+) A-I      intronic chr9:90189580(+) A-I      intronic chr9:90156314(+) A-I      intronic chr9:90116173(+) A-I      intronic chr9:90176187(+) A-I      intronic chr9:90191656(+) A-I      intronic chr9:90192548(+) A-I      intronic chr9:90155166(+) A-I      intronic chr9:90201083(+) A-I      intronic chr9:90320231(+) A-I      intronic chr9:90200941(+) A-I      intronic chr9:90156201(+) A-I      intronic chr9:90143272(+) A-I      intronic chr9:90199766(+) A-I      intronic chr9:90190020(+) A-I      intronic chr9:90175185(+) A-I      intronic chr9:90315559(+) A-I      intronic chr9:90199731(+) A-I      intronic chr9:90192566(+) A-I      intronic chr9:90155205(+) A-I      intronic chr9:90116233(+) A-I      intronic chr9:90167701(+) A-I      intronic chr9:90201027(+) A-I      intronic chr9:90295226(+) A-I      intronic chr9:90175006(+) A-I      intronic chr9:90174939(+) A-I      intronic chr9:90156398(+) A-I      intronic chr9:90176254(+) A-I      intronic chr9:90155260(+) A-I      intronic chr9:90315644(+) A-I      intronic chr9:90143599(+) A-I      intronic chr9:90160566(+) A-I      intronic chr9:90317699(+) A-I      intronic chr9:90191529(+) A-I      intronic chr9:90315539(+) A-I      intronic chr9:90156317(+) A-I      intronic chr9:90155244(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DAPK1	chr9:90317693(+) A-I intron -    21960545   //22327324 chr9:90317693(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DAPK1	chr9:90112653-90112654(+) m6A 5'UTR//exon//intron       24981863 chr9:90112800-90112801(+) m6A 5'UTR//exon//intron       25456834 chr9:90112808-90112809(+) m6A 5'UTR//exon//intron       25456834 chr9:90112826-90112827(+) m6A 5'UTR//exon//intron       25456834 chr9:90112849-90112850(+) m6A 5'UTR//exon//intron       25456834 chr9:90112997-90112998(+) m6A 5'UTR//exon//intron       - chr9:90113892-90113893(+) m6A 5'UTR//exon       24981863 chr9:90121913-90121914(+) m6A exon//intron       - chr9:90219871-90219872(+) m6A CDS//exon       - chr9:90219950-90219951(+) m6A CDS//exon       - chr9:90219984-90219985(+) m6A CDS//exon       - chr9:90256929-90256930(+) m6A 3'UTR//CDS//exon       24981863 chr9:90266446-90266447(+) m6A 3'UTR//CDS//exon       - chr9:90266498-90266499(+) m6A 3'UTR//CDS//exon       - chr9:90266535-90266536(+) m6A 3'UTR//CDS//exon       - chr9:90266613-90266614(+) m6A 3'UTR//CDS//exon       - chr9:90266625-90266626(+) m6A 3'UTR//CDS//exon       - chr9:90272345-90272346(+) m6A exon//intron       - chr9:90283488-90283489(+) m6A exon//intron       - chr9:90283546-90283547(+) m6A 3'UTR//CDS//exon       - chr9:90283579-90283580(+) m6A 3'UTR//CDS//exon       - chr9:90321067-90321068(+) m6A 3'UTR//CDS       22575960 chr9:90321092-90321093(+) m6A 3'UTR//CDS       22575960 chr9:90321142-90321143(+) m6A 3'UTR//CDS       25456834//24981863//22575960//22608085 chr9:90321188-90321189(+) m6A 3'UTR//CDS       25456834//24981863//22575960//22608085 chr9:90321251-90321252(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321266-90321267(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321280-90321281(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321310-90321311(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321390-90321391(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321437-90321438(+) m6A 3'UTR//CDS       25456834//24981863//22575960//22608085 chr9:90321482-90321483(+) m6A 3'UTR//CDS       25456834//24981863//22575960//22608085 chr9:90321623-90321624(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321752-90321753(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321769-90321770(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321781-90321782(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321881-90321882(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321896-90321897(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321902-90321903(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321921-90321922(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321938-90321939(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321962-90321963(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90321983-90321984(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90322081-90322082(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90322122-90322123(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90322154-90322155(+) m6A 3'UTR//CDS       25456834//24981863//26404942//22575960//22608085 chr9:90322312-90322313(+) m6A 3'UTR       25456834//24981863//22575960//22608085 chr9:90322495-90322496(+) m6A 3'UTR       25456834//24981863//22608085 chr9:90322552-90322553(+) m6A 3'UTR       24981863//22608085 chr9:90323167-90323168(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DAPK1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART3-3p
Interactor2: DAPK1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).