Detail Information

Basic Information:


  VIRBase ID:  

VHID00298444

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-3p:           RNF19A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART1-3p RNF19A
miRBase
Accession/Entrez ID		 MIMAT0003390 25897
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - RNF19

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RNF19A
chr8:101289691(-) A-I      intronic
chr8:101289708(-) A-I      intronic
chr8:101302581(-) A-I      intronic
chr8:101302537(-) A-I      intronic
chr8:101302509(-) A-I      intronic
chr8:101298024(-) A-I      intronic
chr8:101292160(-) A-I      intronic
chr8:101292139(-) A-I      intronic
chr8:101289775(-) A-I      intronic
chr8:101289745(-) A-I      intronic
chr8:101289743(-) A-I      intronic
chr8:101289724(-) A-I      intronic
chr8:101316454(-) A-I      intronic
chr8:101316427(-) A-I      intronic
chr8:101316403(-) A-I      intronic
chr8:101289637(-) A-I      intronic
chr8:101289710(-) A-I      intronic
chr8:101316383(-) A-I      intronic
chr8:101316261(-) A-I      intronic
chr8:101316250(-) A-I      intronic
chr8:101316127(-) A-I      intronic
chr8:101316089(-) A-I      intronic
chr8:101315948(-) A-I      intronic
chr8:101318157(-) A-I      intronic
chr8:101284945(-) A-I      intronic
chr8:101288946(-) A-I      intronic
chr8:101289632(-) A-I      intronic
chr8:101289709(-) A-I      intronic
chr8:101289636(-) A-I      intronic
chr8:101312799(-) A-I      5'UTR
chr8:101312875(-) A-I      5'UTR
chr8:101312759(-) A-I      5'UTR
chr8:101312671(-) A-I      intronic
chr8:101316481(-) A-I      intronic
chr8:101316313(-) A-I      intronic
chr8:101302523(-) A-I      intronic
chr8:101316290(-) A-I      intronic
chr8:101316123(-) A-I      intronic
chr8:101317289(-) A-I      intronic
chr8:101288948(-) A-I      intronic
chr8:101284807(-) A-I      intronic
chr8:101288797(-) A-I      intronic
chr8:101316471(-) A-I      intronic
chr8:101316329(-) A-I      intronic
chr8:101316408(-) A-I      intronic
chr8:101315908(-) A-I      intronic
chr8:101316083(-) A-I      intronic
chr8:101302562(-) A-I      intronic
chr8:101315934(-) A-I      intronic
chr8:101316432(-) A-I      intronic
chr8:101312798(-) A-I      5'UTR
chr8:101312845(-) A-I      5'UTR
chr8:101312765(-) A-I      5'UTR
chr8:101312847(-) A-I      5'UTR
chr8:101316485(-) A-I      intronic
chr8:101308570(-) A-I      intronic
chr8:101316323(-) A-I      intronic
chr8:101302494(-) A-I      intronic
chr8:101316042(-) A-I      intronic
chr8:101316038(-) A-I      intronic
chr8:101316065(-) A-I      intronic
chr8:101316341(-) A-I      intronic
chr8:101316475(-) A-I      intronic
chr8:101289678(-) A-I      intronic
chr8:101308448(-) A-I      intronic
chr8:101316072(-) A-I      intronic
chr8:101317296(-) A-I      intronic
chr8:101288871(-) A-I      intronic
chr8:101316463(-) A-I      intronic
chr8:101316276(-) A-I      intronic
chr8:101315907(-) A-I      intronic
chr8:101316263(-) A-I      intronic
chr8:101316345(-) A-I      intronic
chr8:101315969(-) A-I      intronic
chr8:101315895(-) A-I      intronic
chr8:101316078(-) A-I      intronic
chr8:101316296(-) A-I      intronic
chr8:101286240(-) A-I      intronic
chr8:101315947(-) A-I      intronic
chr8:101312702(-) A-I      intronic
chr8:101302468(-) A-I      intronic
chr8:101316300(-) A-I      intronic
chr8:101315954(-) A-I      intronic
chr8:101286816(-) A-I      intronic
chr8:101288859(-) A-I      intronic
chr8:101315960(-) A-I      intronic
chr8:101301115(-) A-I      intronic
chr8:101316431(-) A-I      intronic
chr8:101288927(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RNF19A
chr8:101271291(-) A-I exon CDS    22327324
chr8:101315917(-) A-I intron -    22327324
chr8:101315934(-) A-I intron -    22327324
chr8:101315947(-) A-I intron -    22327324
chr8:101315954(-) A-I intron -    22327324
chr8:101316281(-) A-I intron -    22327324
chr8:101316300(-) A-I intron -    22327324
chr8:101316323(-) A-I intron -    22327324
chr8:101316341(-) A-I intron -    22327324
chr8:101316475(-) A-I intron -    22327324
chr8:101280019(-) A-G intron -    22484847
chr8:101284807(-) A-G intron -    22484847
chr8:101286172(-) T-C intron -    22484847
chr8:101288797(-) A-G intron -    22484847
chr8:101288861(-) A-G intron -    22484847
chr8:101288903(-) A-G intron -    22484847
chr8:101288927(-) A-G intron -    22484847
chr8:101288948(-) A-G intron -    22484847
chr8:101289678(-) A-G intron -    22484847
chr8:101289792(-) T-C intron -    22484847
chr8:101301115(-) A-G intron -    22484847
chr8:101308585(-) A-T intron -    22484847
chr8:101308593(-) G-T intron -    22484847
chr8:101312765(-) A-G exon 5'UTR    22484847
chr8:101312845(-) A-G exon 5'UTR    22484847
chr8:101312847(-) A-G exon 5'UTR    22484847
chr8:101315907(-) A-G intron -    22484847
chr8:101315908(-) A-G intron -    22484847
chr8:101315917(-) A-G intron -    22484847
chr8:101315934(-) A-G intron -    22484847
chr8:101315947(-) A-G intron -    22484847
chr8:101315954(-) A-G intron -    22484847
chr8:101316042(-) A-G intron -    22484847
chr8:101316044(-) A-G intron -    22484847
chr8:101316081(-) A-G intron -    22484847
chr8:101316118(-) A-G intron -    22484847
chr8:101316281(-) A-G intron -    22484847
chr8:101316290(-) A-G intron -    22484847
chr8:101316293(-) A-G intron -    22484847
chr8:101316296(-) A-G intron -    22484847
chr8:101316300(-) A-G intron -    22484847
chr8:101316306(-) A-G intron -    22484847
chr8:101316323(-) A-G intron -    22484847
chr8:101316329(-) A-G intron -    22484847
chr8:101316341(-) A-G intron -    22484847
chr8:101316345(-) A-G intron -    22484847
chr8:101316431(-) A-G intron -    22484847
chr8:101316432(-) A-G intron -    22484847
chr8:101316441(-) A-G intron -    22484847
chr8:101316457(-) A-G intron -    22484847
chr8:101316463(-) A-G intron -    22484847
chr8:101316475(-) A-G intron -    22484847
chr8:101316481(-) A-G intron -    22484847
chr8:101317233(-) T-C intron -    22484847
chr8:101317296(-) A-G intron -    22484847
chr8:101317358(-) A-C intron -    22484847
chr8:101311310(-) A-G intron -    22484847
chr8:101312372(-) A-G intron -    22484847
chr8:101312382(-) A-G intron -    22484847
chr8:101312385(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RNF19A
chr8:101269665-101269666(-) m6A 3'UTR       26404942
chr8:101269729-101269730(-) m6A 3'UTR       26404942
chr8:101269821-101269822(-) m6A 3'UTR       26404942
chr8:101269867-101269868(-) m6A 3'UTR       26404942
chr8:101270070-101270071(-) m6A 3'UTR       26404942
chr8:101270219-101270220(-) m6A 3'UTR       26404942
chr8:101270357-101270358(-) m6A 3'UTR       26404942
chr8:101270383-101270384(-) m6A 3'UTR       26404942
chr8:101270426-101270427(-) m6A 3'UTR       26404942
chr8:101270522-101270523(-) m6A 3'UTR       26404942
chr8:101270607-101270608(-) m6A 3'UTR       24284625//26404942//27773535//22608085
chr8:101270726-101270727(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101270794-101270795(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101270821-101270822(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101270845-101270846(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101270885-101270886(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101270906-101270907(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101270953-101270954(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101271079-101271080(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101271189-101271190(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101271203-101271204(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101271225-101271226(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101271269-101271270(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101272084-101272085(-) m6A CDS//exon       24209618//26404942//27773535
chr8:101272151-101272152(-) m6A CDS//exon       27773535//22575960
chr8:101273781-101273782(-) m6A CDS//exon//intron       26404942
chr8:101273862-101273863(-) m6A CDS//exon//intron       26404942//27773535
chr8:101273957-101273958(-) m6A CDS//exon//intron       26404942//27773535
chr8:101276276-101276277(-) m6A CDS//exon//intron       26404942
chr8:101287228-101287229(-) m6A CDS//exon       26404942
chr8:101287276-101287277(-) m6A CDS       26404942
chr8:101287298-101287299(-) m6A CDS       24209618//26404942//27773535
chr8:101287321-101287322(-) m6A CDS       24209618//26404942//27773535
chr8:101299734-101299735(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr8:101299977-101299978(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101300019-101300020(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101300030-101300031(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr8:101300085-101300086(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr8:101300310-101300311(-) m6A 5'UTR//CDS       24284625//24981863//26404942//27773535//22608085
chr8:101300346-101300347(-) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085
chr8:101300393-101300394(-) m6A CDS//intron       24981863//26404942//27773535//22608085
chr8:101300438-101300439(-) m6A 5'UTR       24981863//26404942//27773535//22608085
chr8:101300462-101300463(-) m6A 5'UTR       24981863//26404942//27773535//22608085
chr8:101312761-101312762(-) m6A 5'UTR//intron       24981863//26404942//27773535//22608085
chr8:101315389-101315390(-) m6A 5'UTR//exon//intron       26404942
chr8:101315405-101315406(-) m6A 5'UTR//exon//intron       26404942
chr8:101315456-101315457(-) m6A 5'UTR//exon//intron       26404942
chr8:101322190-101322191(-) m6A 5'UTR//exon//intron       24981863//27371828//27773536
chr8:101322247-101322248(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828//27773536
chr8:101322374-101322375(-) m1A 5'UTR//exon//intron       26863196
chr8:101322479-101322480(-) m6A 5'UTR//intron       -
chr8:101324577-101324578(-) m6A 5'UTR//intron       27371828
chr8:101324618-101324619(-) m6A 5'UTR//intron       -
chr8:101348379-101348380(-) m6A 5'UTR//exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate RNF19A
Chromatin K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART1-3p
Interactor2: RNF19A

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase//VIRmiRNA

References:


[1]PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.
[2]PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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