Detail Information

Basic Information:


  VIRBase ID:  

VHID00296311

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART2-5p:           MFSD5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART2-5p MFSD5
miRBase
Accession/Entrez ID		 MIMAT0001000 84975
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - hsMOT2//SLC61A1

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MFSD5
chr12:53645114-53645115(+) m6A exon       24981863
chr12:53645496-53645497(+) m6A 5'UTR//exon       22608085
chr12:53645547-53645548(+) m6A CDS//exon       -
chr12:53645556-53645557(+) m6A CDS//exon       -
chr12:53645960-53645961(+) m6A 5'UTR//intron       24284625//25456834//24981863
chr12:53646039-53646040(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863
chr12:53646678-53646679(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53646699-53646700(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53646749-53646750(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53646813-53646814(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53646984-53646985(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53646995-53646996(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085
chr12:53647151-53647152(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53647280-53647281(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53647292-53647293(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53647321-53647322(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr12:53647355-53647356(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53647429-53647430(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr12:53647442-53647443(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr12:53647732-53647733(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085
chr12:53647825-53647826(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53647893-53647894(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr12:53647984-53647985(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr12:53647998-53647999(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr12:53648101-53648102(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:53648119-53648120(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:53648173-53648174(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MFSD5
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug ebv-miR-BART2-5p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
Dovitinib       135398510

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART2-5p
Interactor2: MFSD5

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


[1]PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.
[2]PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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