Basic Information:

  VIRBase ID:  

VHID00295542

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART2-5p:  MIMAT0001000          SLC39A10:  NM_001127257     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART2-5p	SLC39A10
miRBase Accession/Entrez ID	MIMAT0001000	57181
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	LZT-Hs2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC39A10	chr2:196527233(+) A-I      intronic chr2:196533521(+) A-I      intronic chr2:196539131(+) A-I      intronic chr2:196537075(+) A-I      intronic chr2:196527200(+) A-I      intronic chr2:196536958(+) A-I      intronic chr2:196529657(+) A-I      intronic chr2:196534629(+) A-I      intronic chr2:196533597(+) A-I      intronic chr2:196531324(+) A-I      intronic chr2:196531312(+) A-I      intronic chr2:196529947(+) A-I      intronic chr2:196529792(+) A-I      intronic chr2:196536934(+) A-I      intronic chr2:196534729(+) A-I      intronic chr2:196529697(+) A-I      intronic chr2:196531300(+) A-I      intronic chr2:196529645(+) A-I      intronic chr2:196529660(+) A-I      intronic chr2:196542079(+) A-I      intronic chr2:196531308(+) A-I      intronic chr2:196531395(+) A-I      intronic chr2:196531421(+) A-I      intronic chr2:196533625(+) A-I      intronic chr2:196533692(+) A-I      intronic chr2:196533705(+) A-I      intronic chr2:196534721(+) A-I      intronic chr2:196534730(+) A-I      intronic chr2:196534824(+) A-I      intronic chr2:196534733(+) A-I      intronic chr2:196536959(+) A-I      intronic chr2:196534789(+) A-I      intronic chr2:196534804(+) A-I      intronic chr2:196527020(+) A-I      intronic chr2:196527156(+) A-I      intronic chr2:196538013(+) A-I      intronic chr2:196540418(+) A-I      intronic chr2:196542093(+) A-I      intronic chr2:196542105(+) A-I      intronic chr2:196568421(+) A-I      intronic chr2:196568631(+) A-I      intronic chr2:196538086(+) A-I      intronic chr2:196531233(+) A-I      intronic chr2:196533557(+) A-I      intronic chr2:196527147(+) A-I      intronic chr2:196542554(+) A-I      intronic chr2:196534460(+) A-I      intronic chr2:196534630(+) A-I      intronic chr2:196542107(+) A-I      intronic chr2:196542153(+) A-I      intronic chr2:196531257(+) A-I      intronic chr2:196531460(+) A-I      intronic chr2:196578790(+) A-I      intronic chr2:196537137(+) A-I      intronic chr2:196537052(+) A-I      intronic chr2:196537044(+) A-I      intronic chr2:196542746(+) A-I      intronic chr2:196536984(+) A-I      intronic chr2:196542108(+) A-I      intronic chr2:196527189(+) A-I      intronic chr2:196526186(+) A-I      intronic chr2:196527023(+) A-I      intronic chr2:196554736(+) A-I      intronic chr2:196540229(+) A-I      intronic chr2:196566429(+) A-I      intronic chr2:196578840(+) A-I      intronic chr2:196526182(+) A-I      intronic chr2:196542006(+) A-I      intronic chr2:196534762(+) A-I      intronic chr2:196536874(+) A-I      intronic chr2:196542168(+) A-I      intronic chr2:196533679(+) A-I      intronic chr2:196554700(+) A-I      intronic chr2:196531447(+) A-I      intronic chr2:196530081(+) A-I      intronic chr2:196542734(+) A-I      intronic chr2:196540234(+) A-I      intronic chr2:196531448(+) A-I      intronic chr2:196531283(+) A-I      intronic chr2:196538119(+) A-I      intronic chr2:196536980(+) A-I      intronic chr2:196527132(+) A-I      intronic chr2:196537045(+) A-I      intronic chr2:196537027(+) A-I      intronic chr2:196536967(+) A-I      intronic chr2:196529725(+) A-I      intronic chr2:196530087(+) A-I      intronic chr2:196531322(+) A-I      intronic chr2:196534541(+) A-I      intronic chr2:196538000(+) A-I      intronic chr2:196566437(+) A-I      intronic chr2:196539102(+) A-I      intronic chr2:196539141(+) A-I      intronic chr2:196538144(+) A-I      intronic chr2:196529651(+) A-I      intronic chr2:196529888(+) A-I      intronic chr2:196534682(+) A-I      intronic chr2:196529793(+) A-I      intronic chr2:196554832(+) A-I      intronic chr2:196537995(+) A-I      intronic chr2:196529962(+) A-I      intronic chr2:196529698(+) A-I      intronic chr2:196534736(+) A-I      intronic chr2:196580157(+) A-I      intronic chr2:196531348(+) A-I      intronic chr2:196554739(+) A-I      intronic chr2:196593747(+) A-I      intronic chr2:196554822(+) A-I      intronic chr2:196542159(+) A-I      intronic chr2:196542097(+) A-I      intronic chr2:196530061(+) A-I      intronic chr2:196536981(+) A-I      intronic chr2:196527209(+) A-I      intronic chr2:196542693(+) A-I      intronic chr2:196536996(+) A-I      intronic chr2:196536972(+) A-I      intronic chr2:196531295(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC39A10	chr2:196536874(+) A-G intron -    22484847 chr2:196536984(+) A-G intron -    22484847 chr2:196536996(+) A-G intron -    22484847 chr2:196537027(+) A-G intron -    22484847 chr2:196537045(+) A-G intron -    22484847 chr2:196542006(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC39A10	chr2:196521657-196521658(+) m6A 5'UTR//intron       - chr2:196521676-196521677(+) m6A 5'UTR//intron       - chr2:196521694-196521695(+) m6A 5'UTR//intron       - chr2:196521857-196521858(+) m6A 5'UTR//intron       22575960 chr2:196536439-196536440(+) m6A 5'UTR//intron       24284625//24209618//22608085 chr2:196544849-196544850(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr2:196544879-196544880(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr2:196544963-196544964(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr2:196545017-196545018(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr2:196545028-196545029(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr2:196545186-196545187(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545214-196545215(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545240-196545241(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545272-196545273(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545401-196545402(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545414-196545415(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545423-196545424(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545431-196545432(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545446-196545447(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr2:196545542-196545543(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr2:196545569-196545570(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr2:196545644-196545645(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr2:196545677-196545678(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr2:196573486-196573487(+) m6A 3'UTR//CDS//exon       22575960 chr2:196573528-196573529(+) m6A 3'UTR//CDS//exon       22575960 chr2:196573558-196573559(+) m6A 3'UTR//CDS//exon       24981863//22575960 chr2:196578161-196578162(+) m6A 3'UTR//CDS//exon       24981863//22575960 chr2:196578179-196578180(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:196578184-196578185(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:196578232-196578233(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:196581362-196581363(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr2:196581401-196581402(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr2:196581406-196581407(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr2:196581411-196581412(+) Cm 3'UTR//CDS//exon       - chr2:196581480-196581481(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr2:196581558-196581559(+) m6A 3'UTR//CDS//exon       24284625//22608085 chr2:196581563-196581564(+) m6A 3'UTR//CDS//exon       24284625//22608085 chr2:196599990-196599991(+) m6A 3'UTR       24981863//22608085 chr2:196599999-196600000(+) m6A 3'UTR       24981863//22608085 chr2:196600024-196600025(+) m6A 3'UTR       24981863//22608085 chr2:196600049-196600050(+) m6A 3'UTR       24981863//22608085 chr2:196600073-196600074(+) m6A 3'UTR       24981863//22608085 chr2:196600104-196600105(+) m6A 3'UTR       24981863//22608085 chr2:196600123-196600124(+) m6A 3'UTR       24981863//22608085 chr2:196600145-196600146(+) m6A 3'UTR       24981863//22608085 chr2:196600156-196600157(+) m6A 3'UTR       24981863//22608085 chr2:196600252-196600253(+) m6A 3'UTR       24981863//22575960//22608085 chr2:196600266-196600267(+) m6A 3'UTR       24981863//22575960//22608085 chr2:196600274-196600275(+) m6A 3'UTR       22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLC39A10	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART2-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 Dovitinib       135398510

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART2-5p
Interactor2: SLC39A10

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.