Detail Information

Basic Information:


  VIRBase ID:  

VHID00294832

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART2-5p:           NOB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART2-5p NOB1
miRBase
Accession/Entrez ID		 MIMAT0001000 28987
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - ART-4//MST158//MSTP158//NOB1P//PSMD8BP1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NOB1
chr16:69786833(-) A-I      intronic
chr16:69784096(-) A-I      intronic
chr16:69784109(-) A-I      intronic
chr16:69782024(-) A-I      intronic
chr16:69783637(-) A-I      intronic
chr16:69783651(-) A-I      intronic
chr16:69783711(-) A-I      intronic
chr16:69783769(-) A-I      intronic
chr16:69783915(-) A-I      intronic
chr16:69784090(-) A-I      intronic
chr16:69786968(-) A-I      intronic
chr16:69785157(-) A-I      intronic
chr16:69784063(-) A-I      intronic
chr16:69785061(-) A-I      intronic
chr16:69784495(-) A-I      intronic
chr16:69781985(-) A-I      intronic
chr16:69784101(-) A-I      intronic
chr16:69785186(-) A-I      intronic
chr16:69784021(-) A-I      intronic
chr16:69783969(-) A-I      intronic
chr16:69785081(-) A-I      intronic
chr16:69786625(-) A-I      intronic
chr16:69787805(-) A-I      intronic
chr16:69781946(-) A-I      intronic
chr16:69785142(-) A-I      intronic
chr16:69784087(-) A-I      intronic
chr16:69780564(-) A-I      intronic
chr16:69786670(-) A-I      intronic
chr16:69784150(-) A-I      intronic
chr16:69784045(-) A-I      intronic
chr16:69786668(-) A-I      intronic
chr16:69783709(-) A-I      intronic
chr16:69783715(-) A-I      intronic
chr16:69784044(-) A-I      intronic
chr16:69783974(-) A-I      intronic
chr16:69783970(-) A-I      intronic
chr16:69786824(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NOB1
chr16:69784160(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NOB1
chr16:69775779-69775780(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr16:69775786-69775787(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr16:69775992-69775993(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr16:69776001-69776002(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr16:69776067-69776068(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr16:69776072-69776073(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr16:69776146-69776147(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr16:69776307-69776308(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:69776398-69776399(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr16:69778791-69778792(-) m6A 3'UTR//CDS       24284625//27773535//27773536
chr16:69778870-69778871(-) m6A 3'UTR//CDS       24284625//27773535//27773536
chr16:69778875-69778876(-) m6A 3'UTR//CDS       24284625//27773535//27773536
chr16:69782658-69782659(-) m6A exon//intron       24284625
chr16:69782703-69782704(-) m6A exon//intron       24284625
chr16:69782741-69782742(-) m6A exon//intron       24284625
chr16:69782833-69782834(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr16:69782959-69782960(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828
chr16:69783130-69783131(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr16:69783155-69783156(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr16:69783188-69783189(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr16:69783211-69783212(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr16:69783222-69783223(-) m6A 3'UTR//CDS//exon       27773535
chr16:69783235-69783236(-) m6A 3'UTR//CDS//exon       27773535
chr16:69783499-69783500(-) m6A 3'UTR//CDS//exon//intron       27773535
chr16:69786152-69786153(-) m6A CDS//exon//intron       27773535
chr16:69786158-69786159(-) m6A CDS//exon//intron       27773535
chr16:69786222-69786223(-) m6A CDS//exon//intron       27773535
chr16:69786246-69786247(-) m6A CDS//exon//intron       27773535
chr16:69786253-69786254(-) m6A CDS//exon//intron       27773535
chr16:69788576-69788577(-) m6A CDS//exon       24284625//27773535
chr16:69788615-69788616(-) m6A CDS//exon       24284625//24981863//27773535
chr16:69788627-69788628(-) m6A CDS//exon       24284625//24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate NOB1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug ebv-miR-BART2-5p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
Dovitinib       135398510

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART2-5p
Interactor2: NOB1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//Targetscan
Support Database VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells//BCBL-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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