Basic Information:

  VIRBase ID:  

VHID00292686

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART2-5p:  MIMAT0001000          IREB2:  NM_001320941     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART2-5p	IREB2
miRBase Accession/Entrez ID	MIMAT0001000	3658
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ACO3//IRE-BP 2//IRE-BP2//IRP2//IRP2AD//NDCAMA

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IREB2	chr15:78773086(+) A-I      intronic chr15:78773129(+) A-I      intronic chr15:78759814(+) A-I      intronic chr15:78759756(+) A-I      intronic chr15:78759477(+) A-I      intronic chr15:78755708(+) A-I      intronic chr15:78755703(+) A-I      intronic chr15:78755702(+) A-I      intronic chr15:78755526(+) A-I      intronic chr15:78750885(+) A-I      intronic chr15:78750832(+) A-I      intronic chr15:78748973(+) A-I      intronic chr15:78748853(+) A-I      intronic chr15:78782114(+) A-I      intronic chr15:78782105(+) A-I      intronic chr15:78781444(+) A-I      intronic chr15:78779148(+) A-I      intronic chr15:78779115(+) A-I      intronic chr15:78779035(+) A-I      intronic chr15:78779031(+) A-I      intronic chr15:78778694(+) A-I      intronic chr15:78775229(+) A-I      intronic chr15:78775207(+) A-I      intronic chr15:78774429(+) A-I      intronic chr15:78774425(+) A-I      intronic chr15:78774028(+) A-I      intronic chr15:78773853(+) A-I      intronic chr15:78773625(+) A-I      intronic chr15:78773600(+) A-I      intronic chr15:78773240(+) A-I      intronic chr15:78773220(+) A-I      intronic chr15:78773127(+) A-I      intronic chr15:78772994(+) A-I      intronic chr15:78772988(+) A-I      intronic chr15:78772208(+) A-I      intronic chr15:78771536(+) A-I      intronic chr15:78770929(+) A-I      intronic chr15:78770866(+) A-I      intronic chr15:78763590(+) A-I      intronic chr15:78762007(+) A-I      intronic chr15:78761958(+) A-I      intronic chr15:78761944(+) A-I      intronic chr15:78761938(+) A-I      intronic chr15:78761806(+) A-I      intronic chr15:78761800(+) A-I      intronic chr15:78760281(+) A-I      intronic chr15:78760225(+) A-I      intronic chr15:78759848(+) A-I      intronic chr15:78759846(+) A-I      intronic chr15:78761915(+) A-I      intronic chr15:78759501(+) A-I      intronic chr15:78764970(+) A-I      intronic chr15:78782127(+) A-I      intronic chr15:78759441(+) A-I      intronic chr15:78748957(+) A-I      intronic chr15:78771344(+) A-I      intronic chr15:78773837(+) A-I      intronic chr15:78782553(+) A-I      intronic chr15:78763418(+) A-I      intronic chr15:78761986(+) A-I      intronic chr15:78761865(+) A-I      intronic chr15:78773356(+) A-I      intronic chr15:78760679(+) A-I      intronic chr15:78751240(+) A-I      intronic chr15:78773526(+) A-I      intronic chr15:78756080(+) A-I      intronic chr15:78779091(+) A-I      intronic chr15:78775115(+) A-I      intronic chr15:78761945(+) A-I      intronic chr15:78759912(+) A-I      intronic chr15:78759458(+) A-I      intronic chr15:78778853(+) A-I      intronic chr15:78759890(+) A-I      intronic chr15:78748878(+) A-I      intronic chr15:78781306(+) A-I      intronic chr15:78760649(+) A-I      intronic chr15:78760431(+) A-I      intronic chr15:78772156(+) A-I      intronic chr15:78788661(+) A-I      intronic chr15:78744993(+) A-I      intronic chr15:78759304(+) A-I      intronic chr15:78759869(+) A-I      intronic chr15:78747825(+) A-I      intronic chr15:78772126(+) A-I      intronic chr15:78759437(+) A-I      intronic chr15:78773762(+) A-I      intronic chr15:78778804(+) A-I      intronic chr15:78778794(+) A-I      intronic chr15:78773293(+) A-I      intronic chr15:78743400(+) A-I      intronic chr15:78747221(+) A-I      intronic chr15:78773140(+) A-I      intronic chr15:78774414(+) A-I      intronic chr15:78763301(+) A-I      intronic chr15:78781330(+) A-I      intronic chr15:78763586(+) A-I      intronic chr15:78763531(+) A-I      intronic chr15:78782497(+) A-I      intronic chr15:78760014(+) A-I      intronic chr15:78773519(+) A-I      intronic chr15:78771328(+) A-I      intronic chr15:78748880(+) A-I      intronic chr15:78747136(+) A-I      intronic chr15:78778748(+) A-I      intronic chr15:78747103(+) A-I      intronic chr15:78745289(+) A-I      intronic chr15:78756079(+) A-I      intronic chr15:78763622(+) A-I      intronic chr15:78781333(+) A-I      intronic chr15:78773424(+) A-I      intronic chr15:78763154(+) A-I      intronic chr15:78763483(+) A-I      intronic chr15:78760848(+) A-I      intronic chr15:78772116(+) A-I      intronic chr15:78748953(+) A-I      intronic chr15:78759913(+) A-I      intronic chr15:78773409(+) A-I      intronic chr15:78763246(+) A-I      intronic chr15:78745073(+) A-I      intronic chr15:78778876(+) A-I      intronic chr15:78747862(+) A-I      intronic chr15:78748772(+) A-I      intronic chr15:78773331(+) A-I      intronic chr15:78744994(+) A-I      intronic chr15:78760407(+) A-I      intronic chr15:78747067(+) A-I      intronic chr15:78790248(+) A-I      intronic chr15:78760233(+) A-I      intronic chr15:78759445(+) A-I      intronic chr15:78779129(+) A-I      intronic chr15:78774451(+) A-I      intronic chr15:78759473(+) A-I      intronic chr15:78773791(+) A-I      intronic chr15:78770023(+) A-I      intronic chr15:78747169(+) A-I      intronic chr15:78774329(+) A-I      intronic chr15:78779201(+) A-I      intronic chr15:78771576(+) A-I      intronic chr15:78771051(+) A-I      intronic chr15:78759939(+) A-I      intronic chr15:78774390(+) A-I      intronic chr15:78771320(+) A-I      intronic chr15:78747279(+) A-I      intronic chr15:78747839(+) A-I      intronic chr15:78763534(+) A-I      intronic chr15:78773832(+) A-I      intronic chr15:78773120(+) A-I      intronic chr15:78771023(+) A-I      intronic chr15:78763407(+) A-I      intronic chr15:78773471(+) A-I      intronic chr15:78774473(+) A-I      intronic chr15:78760655(+) A-I      intronic chr15:78781290(+) A-I      intronic chr15:78770930(+) A-I      intronic chr15:78776205(+) A-I      intronic chr15:78760238(+) A-I      intronic chr15:78773470(+) A-I      intronic chr15:78761985(+) A-I      intronic chr15:78779192(+) A-I      intronic chr15:78759303(+) A-I      intronic chr15:78759873(+) A-I      intronic chr15:78748888(+) A-I      intronic chr15:78760019(+) A-I      intronic chr15:78761954(+) A-I      intronic chr15:78755519(+) A-I      intronic chr15:78778788(+) A-I      intronic chr15:78781443(+) A-I      intronic chr15:78773536(+) A-I      intronic chr15:78747260(+) A-I      intronic chr15:78773164(+) A-I      intronic chr15:78763106(+) A-I      intronic chr15:78759295(+) A-I      intronic chr15:78761807(+) A-I      intronic chr15:78747175(+) A-I      intronic chr15:78779124(+) A-I      intronic chr15:78761971(+) A-I      intronic chr15:78760715(+) A-I      intronic chr15:78759500(+) A-I      intronic chr15:78773128(+) A-I      intronic chr15:78781307(+) A-I      intronic chr15:78764971(+) A-I      intronic chr15:78747110(+) A-I      intronic chr15:78772834(+) A-I      intronic chr15:78773230(+) A-I      intronic chr15:78747162(+) A-I      intronic chr15:78792378(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IREB2	chr15:78747279(+) A-G intron -    22484847 chr15:78761807(+) A-G intron -    22484847 chr15:78763407(+) A-G intron -    22484847 chr15:78773230(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IREB2	chr15:78730519-78730520(+) m6A 5'UTR//intron       24981863 chr15:78762914-78762915(+) Gm 3'UTR//CDS//exon//intron       - chr15:78789596-78789597(+) m6A 3'UTR//CDS       24284625//24981863//22608085 chr15:78789622-78789623(+) m6A 3'UTR//CDS       24284625//24981863//22575960//22608085 chr15:78790442-78790443(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:78790459-78790460(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:78790542-78790543(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr15:78790723-78790724(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr15:78790759-78790760(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr15:78790845-78790846(+) m6A 3'UTR       24209618//24981863//22608085 chr15:78790906-78790907(+) m6A 3'UTR       24981863//22608085 chr15:78790946-78790947(+) m6A 3'UTR       24981863//22608085 chr15:78790986-78790987(+) m6A 3'UTR       24981863//22608085 chr15:78791863-78791864(+) m6A 3'UTR       24981863//22608085 chr15:78791871-78791872(+) m6A 3'UTR       24981863//22608085 chr15:78791885-78791886(+) m6A 3'UTR       24981863//22608085 chr15:78791895-78791896(+) m6A 3'UTR       24981863//22608085 chr15:78791949-78791950(+) m6A 3'UTR       24981863//22608085 chr15:78791961-78791962(+) m6A 3'UTR       24981863//22608085 chr15:78792096-78792097(+) m6A 3'UTR       - chr15:78792183-78792184(+) m6A 3'UTR       - chr15:78793351-78793352(+) Y 3'UTR       26075521 chr15:78793567-78793568(+) m6A 3'UTR       27773535 chr15:78793623-78793624(+) m6A 3'UTR       27773535 chr15:78793658-78793659(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IREB2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART2-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 Dovitinib       135398510

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART2-5p
Interactor2: IREB2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.