Basic Information:

  VIRBase ID:  

VHID00291462

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:  MIMAT0000999          ZNF555:  NM_001172775     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART1-5p	ZNF555
miRBase Accession/Entrez ID	MIMAT0000999	148254
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF555	chr19:2855397(+) A-I      3'UTR chr19:2843261(+) A-I      intronic chr19:2844335(+) A-I      intronic chr19:2843011(+) A-I      intronic chr19:2844330(+) A-I      intronic chr19:2843023(+) A-I      intronic chr19:2857698(+) A-I      3'UTR chr19:2856344(+) A-I      3'UTR chr19:2857766(+) A-I      3'UTR chr19:2857959(+) A-I      3'UTR chr19:2856264(+) A-I      3'UTR chr19:2856364(+) A-I      3'UTR chr19:2855461(+) A-I      3'UTR chr19:2856368(+) A-I      3'UTR chr19:2856224(+) A-I      3'UTR chr19:2856386(+) A-I      3'UTR chr19:2855302(+) A-I      3'UTR chr19:2855384(+) A-I      3'UTR chr19:2855434(+) A-I      3'UTR chr19:2856412(+) A-I      3'UTR chr19:2856277(+) A-I      3'UTR chr19:2856400(+) A-I      3'UTR chr19:2856486(+) A-I      3'UTR chr19:2843397(+) A-I      intronic chr19:2842888(+) A-I      intronic chr19:2842930(+) A-I      intronic chr19:2842881(+) A-I      intronic chr19:2851875(+) A-I      intronic chr19:2842920(+) A-I      intronic chr19:2857973(+) A-I      3'UTR chr19:2857718(+) A-I      3'UTR chr19:2858077(+) A-I      3'UTR chr19:2855470(+) A-I      3'UTR chr19:2856377(+) A-I      3'UTR chr19:2855362(+) A-I      3'UTR chr19:2856465(+) A-I      3'UTR chr19:2856302(+) A-I      3'UTR chr19:2855501(+) A-I      3'UTR chr19:2855393(+) A-I      3'UTR chr19:2856342(+) A-I      3'UTR chr19:2855310(+) A-I      3'UTR chr19:2855311(+) A-I      3'UTR chr19:2855429(+) A-I      3'UTR chr19:2855499(+) A-I      3'UTR chr19:2855428(+) A-I      3'UTR chr19:2855474(+) A-I      3'UTR chr19:2855406(+) A-I      3'UTR chr19:2856296(+) A-I      3'UTR chr19:2842894(+) A-I      intronic chr19:2855365(+) A-I      3'UTR chr19:2856403(+) A-I      3'UTR chr19:2855398(+) A-I      3'UTR chr19:2855363(+) A-I      3'UTR chr19:2858005(+) A-I      3'UTR chr19:2844489(+) A-I      intronic chr19:2842962(+) A-I      intronic chr19:2842879(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF555	chr19:2853052(+) A-I exon CDS    15342557 chr19:2853566(+) A-I exon CDS    15342557 chr19:2855284(+) A-I exon 3'UTR    15342557 chr19:2855297(+) A-I exon 3'UTR    15342557 chr19:2855372(+) A-I exon 3'UTR    15342557 chr19:2855428(+) A-I exon 3'UTR    15342557 chr19:2855429(+) A-I exon 3'UTR    15342557 chr19:2855469(+) A-I exon 3'UTR    15342557 chr19:2855470(+) A-I exon 3'UTR    15342557 chr19:2855474(+) A-I exon 3'UTR    15342557 chr19:2855501(+) A-I exon 3'UTR    15342557 chr19:2855794(+) A-I exon 3'UTR    15342557 chr19:2856272(+) A-I exon 3'UTR    15342557 chr19:2856296(+) A-I exon 3'UTR    15342557 chr19:2856302(+) A-I exon 3'UTR    15342557 chr19:2856332(+) A-I exon 3'UTR    15342557 chr19:2856342(+) A-I exon 3'UTR    15342557 chr19:2856377(+) A-I exon 3'UTR    15342557 chr19:2856403(+) A-I exon 3'UTR    15342557 chr19:2856465(+) A-I exon 3'UTR    15342557 chr19:2856334(+) T-C intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF555	chr19:2852485-2852486(+) m6A CDS       24284625//25456834//24981863//22608085 chr19:2852566-2852567(+) m6A CDS       24284625//25456834//24981863//22608085 chr19:2852572-2852573(+) m6A CDS       24284625//25456834//24981863//22608085 chr19:2852639-2852640(+) m6A CDS       24284625//25456834//24981863//22608085 chr19:2852656-2852657(+) m6A CDS       24284625//25456834//24981863//22608085 chr19:2852684-2852685(+) m6A CDS       24284625//25456834//24981863//22608085 chr19:2852741-2852742(+) m6A CDS       24981863//27773535//22608085 chr19:2852881-2852882(+) m6A CDS       22608085 chr19:2852965-2852966(+) m6A CDS       22608085 chr19:2853049-2853050(+) m6A CDS       22608085 chr19:2853076-2853077(+) m6A CDS       22608085 chr19:2853091-2853092(+) m6A CDS       22608085 chr19:2853104-2853105(+) m6A CDS       22608085 chr19:2853133-2853134(+) m6A CDS       22608085 chr19:2853160-2853161(+) m6A CDS       22608085 chr19:2853175-2853176(+) m6A CDS       22608085 chr19:2853188-2853189(+) m6A CDS       24284625//22608085 chr19:2853217-2853218(+) m6A CDS       24284625//22608085 chr19:2853227-2853228(+) m6A CDS       24284625//22608085 chr19:2853244-2853245(+) m6A CDS       24284625//24981863//22608085 chr19:2853301-2853302(+) m6A CDS       24284625//24981863//22608085 chr19:2853328-2853329(+) m6A CDS       24284625//24981863//22608085 chr19:2853356-2853357(+) m6A CDS       24284625//24981863//22608085 chr19:2853385-2853386(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:2853395-2853396(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:2853412-2853413(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:2853469-2853470(+) m6A CDS       24284625//25456834//24981863//22608085 chr19:2853492-2853493(+) m6A CDS       24284625//25456834//24981863//22608085 chr19:2853553-2853554(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr19:2853565-2853566(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr19:2853580-2853581(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr19:2853625-2853626(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr19:2853730-2853731(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr19:2853748-2853749(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr19:2853832-2853833(+) m6A CDS       24284625//24981863//22608085 chr19:2853853-2853854(+) m6A CDS       24284625//24981863//22608085 chr19:2853970-2853971(+) m6A 3'UTR       24981863//22608085 chr19:2854008-2854009(+) m6A 3'UTR       24981863//22608085 chr19:2854064-2854065(+) m6A 3'UTR       22608085 chr19:2854095-2854096(+) m6A 3'UTR       22608085 chr19:2857786-2857787(+) m6A 3'UTR       22608085 chr19:2857829-2857830(+) m6A 3'UTR       22608085 chr19:2857858-2857859(+) m6A 3'UTR       22608085 chr19:2857869-2857870(+) m6A 3'UTR       22608085 chr19:2857894-2857895(+) m6A 3'UTR       24284625 chr19:2857949-2857950(+) m6A 3'UTR       24284625 chr19:2858163-2858164(+) m6A 3'UTR       22608085 chr19:2858190-2858191(+) m6A 3'UTR       22608085 chr19:2858195-2858196(+) m6A 3'UTR       22608085 chr19:2858250-2858251(+) m6A 3'UTR       24284625//22608085 chr19:2858266-2858267(+) m6A 3'UTR       22608085 chr19:2858278-2858279(+) m6A 3'UTR       22608085 chr19:2858298-2858299(+) m6A 3'UTR       22608085 chr19:2859255-2859256(+) m6A 3'UTR       - chr19:2859353-2859354(+) m6A 3'UTR       24284625//22608085 chr19:2859406-2859407(+) m6A 3'UTR       24284625//25456834//22608085 chr19:2859425-2859426(+) m6A 3'UTR       24284625//25456834//22608085 chr19:2859443-2859444(+) m6A 3'UTR       25456834//22608085 chr19:2859509-2859510(+) m6A 3'UTR       25456834//22608085 chr19:2859642-2859643(+) m6A 3'UTR       22608085 chr19:2859675-2859676(+) m6A 3'UTR       25456834 chr19:2859746-2859747(+) m6A 3'UTR       25456834 chr19:2860003-2860004(+) m6A 3'UTR       - chr19:2860012-2860013(+) m6A 3'UTR       - chr19:2860055-2860056(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZNF555	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART1-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART1-5p
Interactor2: ZNF555

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).