Basic Information:

  VIRBase ID:  

VHID00291233

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:  MIMAT0000999          UBE3D:  NM_001350604     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART1-5p	UBE3D
miRBase Accession/Entrez ID	MIMAT0000999	90025
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C6orf157//H10BH//UBE2CBP//YJR141W

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBE3D	chr6:83690067(-) A-I      intronic chr6:83690060(-) A-I      intronic chr6:83690053(-) A-I      intronic chr6:83695249(-) A-I      intronic chr6:83695251(-) A-I      intronic chr6:83695256(-) A-I      intronic chr6:83677482(-) A-I      intronic chr6:83677493(-) A-I      intronic chr6:83677496(-) A-I      intronic chr6:83651555(-) A-I      intronic chr6:83651559(-) A-I      intronic chr6:83651596(-) A-I      intronic chr6:83651610(-) A-I      intronic chr6:83651612(-) A-I      intronic chr6:83694843(-) A-I      intronic chr6:83651589(-) A-I      intronic chr6:83694803(-) A-I      intronic chr6:83694784(-) A-I      intronic chr6:83694764(-) A-I      intronic chr6:83742909(-) A-I      intronic chr6:83651617(-) A-I      intronic chr6:83690041(-) A-I      intronic chr6:83695238(-) A-I      intronic chr6:83749991(-) A-I      intronic chr6:83712321(-) A-I      intronic chr6:83710742(-) A-I      intronic chr6:83710724(-) A-I      intronic chr6:83710692(-) A-I      intronic chr6:83695196(-) A-I      intronic chr6:83695104(-) A-I      intronic chr6:83694821(-) A-I      intronic chr6:83694798(-) A-I      intronic chr6:83694767(-) A-I      intronic chr6:83695971(-) A-I      intronic chr6:83694615(-) A-I      intronic chr6:83687554(-) A-I      intronic chr6:83696182(-) A-I      intronic chr6:83712260(-) A-I      intronic chr6:83705618(-) A-I      intronic chr6:83604983(-) A-I      intronic chr6:83606523(-) A-I      intronic chr6:83710636(-) A-I      intronic chr6:83606557(-) A-I      intronic chr6:83606558(-) A-I      intronic chr6:83671509(-) A-I      intronic chr6:83671518(-) A-I      intronic chr6:83671581(-) A-I      intronic chr6:83700224(-) A-I      intronic chr6:83749981(-) A-I      intronic chr6:83749501(-) A-I      intronic chr6:83749495(-) A-I      intronic chr6:83749474(-) A-I      intronic chr6:83671655(-) A-I      intronic chr6:83686644(-) A-I      intronic chr6:83686640(-) A-I      intronic chr6:83676180(-) A-I      intronic chr6:83737068(-) A-I      intronic chr6:83736606(-) A-I      intronic chr6:83736565(-) A-I      intronic chr6:83736102(-) A-I      intronic chr6:83736086(-) A-I      intronic chr6:83736084(-) A-I      intronic chr6:83736048(-) A-I      intronic chr6:83676126(-) A-I      intronic chr6:83686666(-) A-I      intronic chr6:83696168(-) A-I      intronic chr6:83695998(-) A-I      intronic chr6:83700239(-) A-I      intronic chr6:83696952(-) A-I      intronic chr6:83695284(-) A-I      intronic chr6:83695286(-) A-I      intronic chr6:83695970(-) A-I      intronic chr6:83695214(-) A-I      intronic chr6:83695210(-) A-I      intronic chr6:83731329(-) A-I      intronic chr6:83731340(-) A-I      intronic chr6:83731342(-) A-I      intronic chr6:83731466(-) A-I      intronic chr6:83731476(-) A-I      intronic chr6:83731949(-) A-I      intronic chr6:83736602(-) A-I      intronic chr6:83736509(-) A-I      intronic chr6:83736535(-) A-I      intronic chr6:83681438(-) A-I      intronic chr6:83604908(-) A-I      intronic chr6:83696081(-) A-I      intronic chr6:83731065(-) A-I      intronic chr6:83694714(-) A-I      intronic chr6:83695220(-) A-I      intronic chr6:83695250(-) A-I      intronic chr6:83737047(-) A-I      intronic chr6:83710795(-) A-I      intronic chr6:83694866(-) A-I      intronic chr6:83710701(-) A-I      intronic chr6:83696078(-) A-I      intronic chr6:83731147(-) A-I      intronic chr6:83735908(-) A-I      intronic chr6:83744735(-) A-I      intronic chr6:83744768(-) A-I      intronic chr6:83630729(-) A-I      intronic chr6:83736058(-) A-I      intronic chr6:83604820(-) A-I      intronic chr6:83677499(-) A-I      intronic chr6:83736549(-) A-I      intronic chr6:83744805(-) A-I      intronic chr6:83744800(-) A-I      intronic chr6:83712238(-) A-I      intronic chr6:83749432(-) A-I      intronic chr6:83705620(-) A-I      intronic chr6:83696960(-) A-I      intronic chr6:83774075(-) A-I      intronic chr6:83735947(-) A-I      intronic chr6:83744666(-) A-I      intronic chr6:83736575(-) A-I      intronic chr6:83731011(-) A-I      intronic chr6:83695246(-) A-I      intronic chr6:83696951(-) A-I      intronic chr6:83712296(-) A-I      intronic chr6:83744657(-) A-I      intronic chr6:83696737(-) A-I      intronic chr6:83749542(-) A-I      intronic chr6:83744698(-) A-I      intronic chr6:83710770(-) A-I      intronic chr6:83604922(-) A-I      intronic chr6:83744817(-) A-I      intronic chr6:83671559(-) A-I      intronic chr6:83694797(-) A-I      intronic chr6:83671496(-) A-I      intronic chr6:83749885(-) A-I      intronic chr6:83744874(-) A-I      intronic chr6:83744886(-) A-I      intronic chr6:83749500(-) A-I      intronic chr6:83732013(-) A-I      intronic chr6:83736585(-) A-I      intronic chr6:83681429(-) A-I      intronic chr6:83696068(-) A-I      intronic chr6:83696726(-) A-I      intronic chr6:83737055(-) A-I      intronic chr6:83712304(-) A-I      intronic chr6:83736118(-) A-I      intronic chr6:83709187(-) A-I      intronic chr6:83677477(-) A-I      intronic chr6:83696151(-) A-I      intronic chr6:83677485(-) A-I      intronic chr6:83712212(-) A-I      intronic chr6:83679143(-) A-I      intronic chr6:83749545(-) A-I      intronic chr6:83731950(-) A-I      intronic chr6:83696159(-) A-I      intronic chr6:83696007(-) A-I      intronic chr6:83737072(-) A-I      intronic chr6:83694613(-) A-I      intronic chr6:83696802(-) A-I      intronic chr6:83712400(-) A-I      intronic chr6:83710800(-) A-I      intronic chr6:83749640(-) A-I      intronic chr6:83694770(-) A-I      intronic chr6:83696976(-) A-I      intronic chr6:83710688(-) A-I      intronic chr6:83696103(-) A-I      intronic chr6:83695114(-) A-I      intronic chr6:83749897(-) A-I      intronic chr6:83731142(-) A-I      intronic chr6:83696932(-) A-I      intronic chr6:83749461(-) A-I      intronic chr6:83709220(-) A-I      intronic chr6:83736145(-) A-I      intronic chr6:83696740(-) A-I      intronic chr6:83736490(-) A-I      intronic chr6:83712347(-) A-I      intronic chr6:83772947(-) A-I      NonSyn:Tyr->Cys

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBE3D	chr6:83736535(-) A-I intron -    22327324 chr6:83743357(-) A-I intron -    22327324 chr6:83743398(-) A-I intron -    22327324 chr6:83742900(-) A-G intron -    22484847 chr6:83742908(-) A-G intron -    22484847 chr6:83742911(-) A-G intron -    22484847 chr6:83743105(-) A-G intron -    22484847 chr6:83743220(-) A-G intron -    22484847 chr6:83743348(-) A-G intron -    22484847 chr6:83743357(-) A-G intron -    22484847 chr6:83743398(-) A-G intron -    22484847 chr6:83679143(-) A-G intron -    22484847 chr6:83681429(-) A-G intron -    22484847 chr6:83681438(-) A-G intron -    22484847 chr6:83694668(-) A-G intron -    22484847 chr6:83694797(-) A-G intron -    22484847 chr6:83696007(-) A-G intron -    22484847 chr6:83696107(-) A-G intron -    22484847 chr6:83696151(-) A-G intron -    22484847 chr6:83696159(-) A-G intron -    22484847 chr6:83696737(-) A-G intron -    22484847 chr6:83696932(-) A-G intron -    22484847 chr6:83710770(-) A-G intron -    22484847 chr6:83710795(-) A-G intron -    22484847 chr6:83731147(-) A-G intron -    22484847 chr6:83731950(-) A-G intron -    22484847 chr6:83732013(-) A-G intron -    22484847 chr6:83736490(-) A-G intron -    22484847 chr6:83736535(-) A-G intron -    22484847 chr6:83736574(-) A-G intron -    22484847 chr6:83736602(-) A-G intron -    22484847 chr6:83736611(-) A-G intron -    22484847 chr6:83737046(-) A-G intron -    22484847 chr6:83737047(-) A-G intron -    22484847 chr6:83737072(-) A-G intron -    22484847 chr6:83744657(-) A-G intron -    22484847 chr6:83744666(-) A-G intron -    22484847 chr6:83744698(-) A-G intron -    22484847 chr6:83744732(-) A-G intron -    22484847 chr6:83744817(-) A-G intron -    22484847 chr6:83744874(-) A-G intron -    22484847 chr6:83744886(-) A-G intron -    22484847 chr6:83746591(-) A-G intron -    22484847 chr6:83746593(-) A-G intron -    22484847 chr6:83749432(-) A-G intron -    22484847 chr6:83749461(-) A-G intron -    22484847 chr6:83749500(-) A-G intron -    22484847 chr6:83749542(-) A-G intron -    22484847 chr6:83749545(-) A-G intron -    22484847 chr6:83749640(-) A-G intron -    22484847 chr6:83749885(-) A-G intron -    22484847 chr6:83749897(-) A-G intron -    22484847 chr6:83749937(-) A-G intron -    22484847 chr6:83749948(-) A-G intron -    22484847 chr6:83749978(-) A-G intron -    22484847 chr6:83773038(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBE3D	chr6:83602272-83602273(-) m6A 3'UTR//exon       27773535//22608085 chr6:83602299-83602300(-) m6A 3'UTR//exon       27773535//22608085 chr6:83602330-83602331(-) m6A 3'UTR//exon       27773535//22608085 chr6:83602365-83602366(-) m6A 3'UTR//exon       27773535//22608085 chr6:83602536-83602537(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr6:83602543-83602544(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr6:83602638-83602639(-) m6A 3'UTR//exon       22608085 chr6:83602644-83602645(-) m6A 3'UTR//exon       22608085 chr6:83746065-83746066(-) m6A 3'UTR//intron       27773535 chr6:83746073-83746074(-) m6A 3'UTR//intron       27773535 chr6:83746186-83746187(-) m6A 3'UTR//intron       27773535 chr6:83754272-83754273(-) Y 3'UTR//CDS       26075521 chr6:83775389-83775390(-) m6A CDS//intron       27773536 chr6:83775450-83775451(-) m6A 5'UTR       27773536 chr6:83775474-83775475(-) m6A 5'UTR       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	UBE3D	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART1-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART1-5p
Interactor2: UBE3D

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.