Basic Information:

  VIRBase ID:  

VHID00290511

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:  MIMAT0000999          RNF125:  NM_017831     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART1-5p	RNF125
miRBase Accession/Entrez ID	MIMAT0000999	54941
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	TNORS//TRAC-1//TRAC1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RNF125	chr18:29651250(+) A-I      3'UTR chr18:29651247(+) A-I      3'UTR chr18:29651239(+) A-I      3'UTR chr18:29648867(+) A-I      3'UTR chr18:29650867(+) A-I      3'UTR chr18:29650813(+) A-I      3'UTR chr18:29650807(+) A-I      3'UTR chr18:29650394(+) A-I      3'UTR chr18:29650357(+) A-I      3'UTR chr18:29652060(+) A-I      3'UTR chr18:29652089(+) A-I      3'UTR chr18:29652113(+) A-I      3'UTR chr18:29649060(+) A-I      3'UTR chr18:29652035(+) A-I      3'UTR chr18:29651901(+) A-I      3'UTR chr18:29650236(+) A-I      3'UTR chr18:29650210(+) A-I      3'UTR chr18:29650204(+) A-I      3'UTR chr18:29649165(+) A-I      3'UTR chr18:29649129(+) A-I      3'UTR chr18:29651373(+) A-I      3'UTR chr18:29650103(+) A-I      3'UTR chr18:29648970(+) A-I      3'UTR chr18:29649010(+) A-I      3'UTR chr18:29649011(+) A-I      3'UTR chr18:29651336(+) A-I      3'UTR chr18:29650262(+) A-I      3'UTR chr18:29650277(+) A-I      3'UTR chr18:29650284(+) A-I      3'UTR chr18:29651234(+) A-I      3'UTR chr18:29650291(+) A-I      3'UTR chr18:29651117(+) A-I      3'UTR chr18:29649049(+) A-I      3'UTR chr18:29650261(+) A-I      3'UTR chr18:29644058(+) A-I      intronic chr18:29628269(+) A-I      intronic chr18:29628237(+) A-I      intronic chr18:29628026(+) A-I      intronic chr18:29633491(+) A-I      intronic chr18:29634079(+) A-I      intronic chr18:29627970(+) A-I      intronic chr18:29627863(+) A-I      intronic chr18:29627828(+) A-I      intronic chr18:29627080(+) A-I      intronic chr18:29634087(+) A-I      intronic chr18:29634096(+) A-I      intronic chr18:29643063(+) A-I      intronic chr18:29626439(+) A-I      intronic chr18:29634158(+) A-I      intronic chr18:29634242(+) A-I      intronic chr18:29635081(+) A-I      intronic chr18:29626405(+) A-I      intronic chr18:29626296(+) A-I      intronic chr18:29625511(+) A-I      intronic chr18:29625357(+) A-I      intronic chr18:29635181(+) A-I      intronic chr18:29635758(+) A-I      intronic chr18:29635760(+) A-I      intronic chr18:29635781(+) A-I      intronic chr18:29625351(+) A-I      intronic chr18:29617557(+) A-I      intronic chr18:29617534(+) A-I      intronic chr18:29617520(+) A-I      intronic chr18:29617435(+) A-I      intronic chr18:29613661(+) A-I      intronic chr18:29632349(+) A-I      intronic chr18:29638065(+) A-I      intronic chr18:29638060(+) A-I      intronic chr18:29638044(+) A-I      intronic chr18:29637398(+) A-I      intronic chr18:29637377(+) A-I      intronic chr18:29635787(+) A-I      intronic chr18:29635782(+) A-I      intronic chr18:29632335(+) A-I      intronic chr18:29635792(+) A-I      intronic chr18:29644686(+) A-I      intronic chr18:29646262(+) A-I      intronic chr18:29631473(+) A-I      intronic chr18:29631370(+) A-I      intronic chr18:29646271(+) A-I      intronic chr18:29604632(+) A-I      intronic chr18:29612809(+) A-I      intronic chr18:29644032(+) A-I      intronic chr18:29644057(+) A-I      intronic chr18:29632362(+) A-I      intronic chr18:29650341(+) A-I      3'UTR chr18:29648895(+) A-I      3'UTR chr18:29650090(+) A-I      3'UTR chr18:29650356(+) A-I      3'UTR chr18:29650358(+) A-I      3'UTR chr18:29650140(+) A-I      3'UTR chr18:29649109(+) A-I      3'UTR chr18:29650264(+) A-I      3'UTR chr18:29649006(+) A-I      3'UTR chr18:29649092(+) A-I      3'UTR chr18:29650281(+) A-I      3'UTR chr18:29649012(+) A-I      3'UTR chr18:29650338(+) A-I      3'UTR chr18:29651172(+) A-I      3'UTR chr18:29652151(+) A-I      3'UTR chr18:29650365(+) A-I      3'UTR chr18:29650133(+) A-I      3'UTR chr18:29652105(+) A-I      3'UTR chr18:29651237(+) A-I      3'UTR chr18:29650203(+) A-I      3'UTR chr18:29649046(+) A-I      3'UTR chr18:29650336(+) A-I      3'UTR chr18:29650767(+) A-I      3'UTR chr18:29650856(+) A-I      3'UTR chr18:29650310(+) A-I      3'UTR chr18:29651319(+) A-I      3'UTR chr18:29650876(+) A-I      3'UTR chr18:29650723(+) A-I      3'UTR chr18:29650943(+) A-I      3'UTR chr18:29651227(+) A-I      3'UTR chr18:29651215(+) A-I      3'UTR chr18:29650302(+) A-I      3'UTR chr18:29651202(+) A-I      3'UTR chr18:29650690(+) A-I      3'UTR chr18:29650732(+) A-I      3'UTR chr18:29651197(+) A-I      3'UTR chr18:29650129(+) A-I      3'UTR chr18:29650927(+) A-I      3'UTR chr18:29650201(+) A-I      3'UTR chr18:29650901(+) A-I      3'UTR chr18:29650121(+) A-I      3'UTR chr18:29650869(+) A-I      3'UTR chr18:29651371(+) A-I      3'UTR chr18:29650841(+) A-I      3'UTR chr18:29650804(+) A-I      3'UTR chr18:29650373(+) A-I      3'UTR chr18:29649124(+) A-I      3'UTR chr18:29650797(+) A-I      3'UTR chr18:29650718(+) A-I      3'UTR chr18:29650184(+) A-I      3'UTR chr18:29652084(+) A-I      3'UTR chr18:29652037(+) A-I      3'UTR chr18:29650275(+) A-I      3'UTR chr18:29651177(+) A-I      3'UTR chr18:29624242(+) A-I      intronic chr18:29646227(+) A-I      intronic chr18:29605349(+) A-I      intronic chr18:29605467(+) A-I      intronic chr18:29605473(+) A-I      intronic chr18:29605572(+) A-I      intronic chr18:29646235(+) A-I      intronic chr18:29605478(+) A-I      intronic chr18:29636419(+) A-I      intronic chr18:29605570(+) A-I      intronic chr18:29638389(+) A-I      intronic chr18:29628103(+) A-I      intronic chr18:29644725(+) A-I      intronic chr18:29626015(+) A-I      intronic chr18:29626413(+) A-I      intronic chr18:29633479(+) A-I      intronic chr18:29605508(+) A-I      intronic chr18:29605543(+) A-I      intronic chr18:29631490(+) A-I      intronic chr18:29605534(+) A-I      intronic chr18:29631498(+) A-I      intronic chr18:29605549(+) A-I      intronic chr18:29605521(+) A-I      intronic chr18:29605470(+) A-I      intronic chr18:29628038(+) A-I      intronic chr18:29649072(+) A-I      3'UTR chr18:29650847(+) A-I      3'UTR chr18:29648930(+) A-I      3'UTR chr18:29651148(+) A-I      3'UTR chr18:29649044(+) A-I      3'UTR chr18:29652079(+) A-I      3'UTR chr18:29650130(+) A-I      3'UTR chr18:29650724(+) A-I      3'UTR chr18:29650263(+) A-I      3'UTR chr18:29651198(+) A-I      3'UTR chr18:29650325(+) A-I      3'UTR chr18:29650078(+) A-I      3'UTR chr18:29650941(+) A-I      3'UTR chr18:29652066(+) A-I      3'UTR chr18:29649127(+) A-I      3'UTR chr18:29650906(+) A-I      3'UTR chr18:29649066(+) A-I      3'UTR chr18:29649146(+) A-I      3'UTR chr18:29650065(+) A-I      3'UTR chr18:29652109(+) A-I      3'UTR chr18:29652053(+) A-I      3'UTR chr18:29648909(+) A-I      3'UTR chr18:29648950(+) A-I      3'UTR chr18:29651898(+) A-I      3'UTR chr18:29649043(+) A-I      3'UTR chr18:29650850(+) A-I      3'UTR chr18:29650834(+) A-I      3'UTR chr18:29650396(+) A-I      3'UTR chr18:29648947(+) A-I      3'UTR chr18:29651892(+) A-I      3'UTR chr18:29604618(+) A-I      intronic chr18:29651359(+) A-I      3'UTR chr18:29650729(+) A-I      3'UTR chr18:29619196(+) A-I      intronic chr18:29649053(+) A-I      3'UTR chr18:29650107(+) A-I      3'UTR chr18:29650888(+) A-I      3'UTR chr18:29651963(+) A-I      3'UTR chr18:29651263(+) A-I      3'UTR chr18:29651281(+) A-I      3'UTR chr18:29633663(+) A-I      intronic chr18:29649121(+) A-I      3'UTR chr18:29651884(+) A-I      3'UTR chr18:29651890(+) A-I      3'UTR chr18:29648939(+) A-I      3'UTR chr18:29626003(+) A-I      intronic chr18:29649084(+) A-I      3'UTR chr18:29649002(+) A-I      3'UTR chr18:29649116(+) A-I      3'UTR chr18:29649096(+) A-I      3'UTR chr18:29649076(+) A-I      3'UTR chr18:29650395(+) A-I      3'UTR chr18:29648883(+) A-I      3'UTR chr18:29637998(+) A-I      intronic chr18:29649103(+) A-I      3'UTR chr18:29652057(+) A-I      3'UTR chr18:29649070(+) A-I      3'UTR chr18:29649167(+) A-I      3'UTR chr18:29651965(+) A-I      3'UTR chr18:29650785(+) A-I      3'UTR chr18:29650772(+) A-I      3'UTR chr18:29650747(+) A-I      3'UTR chr18:29651240(+) A-I      3'UTR chr18:29651952(+) A-I      3'UTR chr18:29648903(+) A-I      3'UTR chr18:29651937(+) A-I      3'UTR chr18:29649073(+) A-I      3'UTR chr18:29649017(+) A-I      3'UTR chr18:29648904(+) A-I      3'UTR chr18:29650386(+) A-I      3'UTR chr18:29652056(+) A-I      3'UTR chr18:29652043(+) A-I      3'UTR chr18:29650083(+) A-I      3'UTR chr18:29651264(+) A-I      3'UTR chr18:29650084(+) A-I      3'UTR chr18:29650244(+) A-I      3'UTR chr18:29650887(+) A-I      3'UTR chr18:29651340(+) A-I      3'UTR chr18:29651162(+) A-I      3'UTR chr18:29651358(+) A-I      3'UTR chr18:29651874(+) A-I      3'UTR chr18:29648988(+) A-I      3'UTR chr18:29651893(+) A-I      3'UTR chr18:29648927(+) A-I      3'UTR chr18:29650410(+) A-I      3'UTR chr18:29651946(+) A-I      3'UTR chr18:29651297(+) A-I      3'UTR chr18:29651886(+) A-I      3'UTR chr18:29649003(+) A-I      3'UTR chr18:29649005(+) A-I      3'UTR chr18:29650928(+) A-I      3'UTR chr18:29650169(+) A-I      3'UTR chr18:29648999(+) A-I      3'UTR chr18:29636539(+) A-I      intronic chr18:29636573(+) A-I      intronic chr18:29644669(+) A-I      intronic chr18:29619025(+) A-I      intronic chr18:29647058(+) A-I      intronic chr18:29643104(+) A-I      intronic chr18:29644724(+) A-I      intronic chr18:29635680(+) A-I      intronic chr18:29634998(+) A-I      intronic chr18:29628019(+) A-I      intronic chr18:29631460(+) A-I      intronic chr18:29637996(+) A-I      intronic chr18:29644585(+) A-I      intronic chr18:29627834(+) A-I      intronic chr18:29631782(+) A-I      intronic chr18:29626409(+) A-I      intronic chr18:29633469(+) A-I      intronic chr18:29626021(+) A-I      intronic chr18:29642919(+) A-I      intronic chr18:29617542(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RNF125	chr18:29617109(+) A-I exon CDS    15342557 chr18:29648904(+) A-I exon 3'UTR    15342557   //15258596 chr18:29648927(+) A-I exon 3'UTR    15342557   //15258596 chr18:29648942(+) A-I exon 3'UTR    15342557   //15258596   //22028664 chr18:29648947(+) A-I exon 3'UTR    15342557   //15258596   //22028664 chr18:29649002(+) A-I exon 3'UTR    15342557   //15258596   //22028664 chr18:29649004(+) A-I exon 3'UTR    15258596 chr18:29649008(+) A-I exon 3'UTR    15342557   //15258596 chr18:29649013(+) A-I exon 3'UTR    15342557   //15258596 chr18:29649017(+) A-I exon 3'UTR    15342557   //22028664 chr18:29649043(+) A-I exon 3'UTR    15342557   //22028664 chr18:29649079(+) A-I exon 3'UTR    15342557   //22028664 chr18:29649085(+) A-I exon 3'UTR    15342557 chr18:29649096(+) A-I exon 3'UTR    15342557   //22028664 chr18:29649103(+) A-I exon 3'UTR    15342557   //22028664 chr18:29649121(+) A-I exon 3'UTR    15342557 chr18:29651884(+) A-I exon 3'UTR    15258596 chr18:29651886(+) A-I exon 3'UTR    15258596 chr18:29651890(+) A-I exon 3'UTR    15258596 chr18:29651892(+) A-I exon 3'UTR    15258596 chr18:29651893(+) A-I exon 3'UTR    15258596 chr18:29651898(+) A-I exon 3'UTR    15258596 chr18:29651937(+) A-I exon 3'UTR    15258596 chr18:29651945(+) A-I exon 3'UTR    15258596 chr18:29651963(+) A-I exon 3'UTR    15258596 chr18:29652057(+) A-I intron -    22327324 chr18:29652079(+) A-I intron -    22327324 chr18:29652119(+) A-I intron -    22327324 chr18:29605349(+) A-I intron -    22028664 chr18:29605467(+) A-I intron -    22028664 chr18:29605470(+) A-I intron -    22028664 chr18:29605473(+) A-I intron -    22028664 chr18:29605478(+) A-I intron -    22028664 chr18:29605508(+) A-I intron -    22028664 chr18:29605521(+) A-I intron -    22028664 chr18:29605534(+) A-I intron -    22028664 chr18:29605543(+) A-I intron -    22028664 chr18:29605549(+) A-I intron -    22028664 chr18:29605570(+) A-I intron -    22028664 chr18:29605572(+) A-I intron -    22028664 chr18:29648912(+) A-I intron -    22028664 chr18:29648930(+) A-I intron -    22028664 chr18:29648939(+) A-I intron -    22028664 chr18:29648950(+) A-I intron -    22028664 chr18:29649066(+) A-I intron -    22028664 chr18:29649070(+) A-I intron -    22028664 chr18:29649072(+) A-I intron -    22028664 chr18:29649073(+) A-I intron -    22028664 chr18:29649076(+) A-I intron -    22028664 chr18:29649084(+) A-I intron -    22028664 chr18:29649116(+) A-I intron -    22028664 chr18:29649127(+) A-I intron -    22028664 chr18:29649146(+) A-I intron -    22028664 chr18:29649167(+) A-I intron -    22028664 chr18:29651263(+) A-I intron -    21960545 chr18:29652119(+) A-G intron -    21725310   //22484847 chr18:29648903(+) A-G intron -    22484847 chr18:29648927(+) A-G intron -    22484847 chr18:29649002(+) A-G intron -    22484847 chr18:29649017(+) A-G intron -    22484847 chr18:29650083(+) A-G intron -    22484847 chr18:29650104(+) A-G intron -    22484847 chr18:29650107(+) A-G intron -    22484847 chr18:29650169(+) A-G intron -    22484847 chr18:29650729(+) A-G intron -    22484847 chr18:29650785(+) A-G intron -    22484847 chr18:29650833(+) A-G intron -    22484847 chr18:29650929(+) A-G intron -    22484847 chr18:29651198(+) A-G intron -    22484847 chr18:29651886(+) A-G intron -    22484847 chr18:29651890(+) A-G intron -    22484847 chr18:29652057(+) A-G intron -    22484847 chr18:29652079(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RNF125	chr18:29598558-29598559(+) m6A 5'UTR       24981863 chr18:29598656-29598657(+) m6A 5'UTR       24981863 chr18:29625673-29625674(+) Cm 3'UTR//CDS//exon       - chr18:29648303-29648304(+) m6A CDS//exon       24981863 chr18:29648336-29648337(+) m6A CDS//exon       24981863 chr18:29648372-29648373(+) m6A 3'UTR//exon       24981863 chr18:29648406-29648407(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RNF125	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART1-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART1-5p
Interactor2: RNF125

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.